Kasper Dyrberg Rand

Kasper Dyrberg Rand

Professor

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    ORCID: 0000-0002-6337-5489

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    1. Published

      Partial Unwinding of Transmembrane Helices Facilitates Alternating Access in the Neurotransmitter: Sodium Symporter LeuT

      Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 28 Jun 2017

      Research output: Other contribution › Research

    2. Published

      Probing the Conformational Dynamics of Affinity-Enhanced T Cell Receptor Variants upon Binding the Peptide-Bound Major Histocompatibility Complex by Hydrogen/Deuterium Exchange Mass Spectrometry

      Merkle, P. S., Trabjerg, Esben, Hongjian, S., Ferber, M., Cuendet, M. A., Jorgensen, T. J. D., Luescher, I., Irving, M., Zoete, V., Michielin, O. & Rand, Kasper Dyrberg, 2021, In: Biochemistry. 60, 11, p. 859-872

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT: Recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Robert Vandenberg

      Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 2018, In: Science Advances. 4, 5, 12 p., eaar6179.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Probing the Dissociation of Protein Complexes by Means of Gas-Phase H/D Exchange Mass Spectrometry

      Mistarz, U. H., Chandler, S. A., Brown, J. M., Benesch, J. L. P. & Rand, Kasper Dyrberg, 15 Jan 2019, In: Journal of the American Society for Mass Spectrometry. 30, 1, p. 45-57 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Expression, Purification and Characterization of GMZ2'.10C, a Complex Disulphide-Bonded Fusion Protein Vaccine Candidate against the Asexual and Sexual Life-Stages of the Malaria-Causing Plasmodium falciparum Parasite

      Mistarz, U. H., Singh, S. K., Nguyen, T. T. T. N., Roeffen, W., Yang, F., Lissau, C., Madsen, S. M., Vrang, A., Tiendrebeogo, R. W., Kana, Ikhlaq Hussain, Sauerwein, R. W., Theisen, Michael & Rand, Kasper Dyrberg, 1 Sep 2017, In: Pharmaceutical Research. 34, 9, p. 1970-1983 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Probing the Binding Interfaces of Protein Complexes Using Gas-Phase H/D Exchange Mass Spectrometry

      Mistarz, U. H., Brown, J. M., Haselmann, K. F. & Rand, Kasper Dyrberg, 2 Feb 2016, In: Structure. 24, 2, p. 310-318 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Installation, validation, and application examples of two instrumental setups for gas-phase HDX-MS analysis of peptides and proteins

      Mistarz, U. H. & Rand, Kasper Dyrberg, 15 Jul 2018, In: Methods. 144, p. 113-124

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Measuring the binding interfaces of protein complexes by gas-phase hydrogen/deuterium exchange mass spectrometry (gas-phase HDX-MS)

      Mistarz, U. H., Brown, J. M., Haselmann, K. F. & Rand, Kasper Dyrberg, 2015.

      Research output: Contribution to conference › Conference abstract for conference › Research

    9. Published

      UV Photodissociation Mass Spectrometry Accurately Localize Sites of Backbone Deuteration in Peptides

      Mistarz, U. H., Bellina, B., Jensen, P. F., Brown, J. M., Barran, P. E. & Rand, Kasper Dyrberg, 2018, In: Analytical Chemistry. 90, 2, p. 1077-1080 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Simple setup for gas-phase H/D exchange mass spectrometry coupled to electron transfer dissociation and ion mobility for analysis of polypeptide structure on a liquid chromatographic time scale

      Mistarz, U. H., Brown, J. M., Haselmann, K. F. & Rand, Kasper Dyrberg, 2 Dec 2014, In: Analytical Chemistry. 86, 23, p. 11868-76 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Photodissociation Mass Spectrometry Accurately Localizes Sites of Backbone Deuteration in Peptides

      Mistarz, U. H., Bellina, B., Jensen, P. F., Brown, J. M., Barran, P. E. & Rand, Kasper Dyrberg, 14 Nov 2017

      Research output: Other contribution › Research

    12. Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscs

      Morgan, C. R., Hebling, C. M., Rand, Kasper Dyrberg, Stafford, D. W., Jorgenson, J. W. & Engen, J. R., 2011, In: Molecular and Cellular Proteomics. 10, 9, p. M111.010876

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Structural Dynamics and Catalytic Properties of a Multimodular Xanthanase

      Moroz, O. V., Jensen, P. F., Mcdonald, S. P., Mcgregor, N., Blagova, E., Comamala, G., Segura, D. R., Anderson, L., Vasu, S. M., Rao, V. P., Giger, L., Sørensen, T. H., Monrad, R. N., Svendsen, A., Nielsen, J. E., Henrissat, B., Davies, G. J., Brumer, H., Rand, Kasper Dyrberg & Wilson, K. S., 6 Jul 2018, In: ACS Catalysis. 8, 7, p. 6021-6034

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Conformational dynamics of the human serotonin transporter during substrate and drug binding

      Möller, I. R., Slivacka, M., Nielsen, A. K., Rasmussen, Søren Gøgsig Faarup, Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 11 Apr 2019, In: Nature Communications. 10, 1, 1687.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Probing the conformational impact of detergents on the integral membrane protein LeuT by global HDX-MS

      Möller, I. R., Merkle, P. S., Calugareanu, D., Comamala, G., Schmidt, S. G., Loland, Claus Juul & Rand, Kasper Dyrberg, 2020, In: Journal of Proteomics. 225, 103845.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Improving the Sequence Coverage of Integral Membrane Proteins during Hydrogen/Deuterium Exchange Mass Spectrometry Experiments

      Möller, I. R., Slivacka, M., Hausner, J., Nielsen, A. K., Pospisilova, E., Rand, Kasper Dyrberg, Liskova, R., Polak, M., Loland, Claus Juul, Kadek, A., Man, P. & Rand, Kasper Dyrberg, 2019, In: Analytical Chemistry. 91, 17, p. 10970-10978 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      A simple sheathless CE-MS interface with a sub-micrometer electrical contact fracture for sensitive analysis of peptide and protein samples

      Nguyen, T. T. T. N., Petersen, Nickolaj J. & Rand, Kasper Dyrberg, 2016, In: Analytica Chimica Acta. 936, p. 157–167 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      A novel sensitive sheathless CE-MS device for peptide and protein analysis

      Nguyen, T. T. T. N., Petersen, Nickolaj J. & Rand, Kasper Dyrberg, 8 Jun 2016. 1 p.

      Research output: Contribution to conference › Conference abstract for conference › Research

    19. Published

      Investigating the utility of minimized sample preparation and high-resolution mass spectrometry for quantification of monoclonal antibody drugs

      Nguyen, T. T. T. N., Mistarz, U. H., Costa, N., Herbet, A., Boquet, D., Becher, F. & Rand, Kasper Dyrberg, 10 Sep 2018, In: Journal of Pharmaceutical and Biomedical Analysis. 159, p. 384-392

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Substrate-Induced Conformational Dynamics of the Dopamine Transporter

      Nielsen, A. K., Moller, I. R., Rasmussen, Søren Gøgsig Faarup, Rand, Kasper Dyrberg & Loland, Claus Juul, 2019, In: Biophysical Society. Annual Meeting. Abstracts. 116, 3, p. 346A 1 p., 1714-Pos.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    21. Published

      Substrate-induced conformational dynamics of the dopamine transporter

      Nielsen, A. K., Möller, I. R., Wang, Y., Rasmussen, Søren Gøgsig Faarup, Lindorff-Larsen, Kresten, Rand, Kasper Dyrberg & Loland, Claus Juul, 2019, In: Nature Communications. 10, 14 p., 2714.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      An intact C-terminal end of albumin is required for long serum half-life

      Nilsen, J., Trabjerg, E., Grevys, A., Azevedo, C., Brennan, S. O., Stensland, M., Wilson, J., Sand, K. M. K., Bern, M., Dalhus, B., Roopenian, D. C., Sandlie, I., Rand, Kasper Dyrberg & Andersen, J. T., Dec 2019, p. 19. 1 p.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    23. Published

      An intact C-terminal end of albumin is required for its long half-life in humans

      Nilsen, J., Trabjerg, Esben, Grevys, A., Azevedo, C., Brennan, S. O., Stensland, M., Wilson, J., Sand, K. M. K., Bern, M., Dalhus, B., Roopenian, D. C., Sandlie, I., Rand, Kasper Dyrberg & Andersen, J. T., 20 Apr 2020, In: Communications Biology. 3, 1, 11 p., 181.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. A combined structural dynamics approach identifies a putative switch in factor VIIa employed by tissue factor to initiate blood coagulation

      Olsen, O. H., Rand, Kasper Dyrberg, Østergaard, H. & Persson, E., 2007, In: Protein Science. 16, 4, p. 671-82 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      A conformational investigation of propeptide binding to the integral membrane protein γ-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry

      Parker, C. H., Morgan, C. R., Rand, Kasper Dyrberg, Engen, J. R., Jorgenson, J. W. & Stafford, D. W., 11 Mar 2014, In: Biochemistry. 53, 9, p. 1511-20 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Side-chain moieties from the N-terminal region of Aβ are Involved in an oligomer-stabilizing network of interactions

      Przygońska, K., Poznański, J., Mistarz, U. H., Rand, Kasper Dyrberg & Dadlez, M., 6 Aug 2018, In: PLoS One. 13, 8, p. 1-25 25 p., e0201761.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Investigation of amide hydrogen back-exchange in Asp and His repeats measured by hydrogen (1H/2H) exchange mass spectrometry

      Rand, Kasper Dyrberg, Lund, F. W., Amon, S. & Jørgensen, Thomas, Apr 2011, In: International Journal of Mass Spectrometry.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Spatially resolved protein hydrogen exchange measured by matrix-assisted laser desorption ionization in-source decay

      Rand, Kasper Dyrberg, Bache, N., Nedertoft, M. M. & Jørgensen, T., 2011, In: Analytical Chemistry. 83, 23, p. 8859-62 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Pinpointing changes in higher-order protein structure by hydrogen/deuterium exchange coupled to electron transfer dissociation mass spectrometry

      Rand, Kasper Dyrberg, 15 Mar 2013, In: International Journal of Mass Spectrometry. 338, p. 2-10 9 p.

      Research output: Contribution to journal › Review › Research › peer-review

    30. Gas-phase hydrogen/deuterium exchange in a traveling wave ion guide for the examination of protein conformations

      Rand, Kasper Dyrberg, Pringle, S. D., Murphy, J. P., Fadgen, K. E., Brown, J. & Engen, J. R., 2009, In: Analytical Chemistry. 81, 24, p. 10019-28 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Protein hydrogen exchange measured at single-residue resolution by electron transfer dissociation mass spectrometry

      Rand, Kasper Dyrberg, Zehl, M., Jensen, O. & Jørgensen, T., 2009, In: Analytical Chemistry. 81, 14, p. 5577-84 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Development of a peptide probe for the occurrence of hydrogen (1H/2H) scrambling upon gas-phase fragmentation

      Rand, Kasper Dyrberg & Jørgensen, T., 2007, In: Analytical Chemistry. 79, 22, p. 8686-93 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Electron capture dissociation proceeds with a low degree of intramolecular migration of peptide amide hydrogens

      Rand, Kasper Dyrberg, Adams, C. M., Zubarev, R. & Jørgensen, T., 2008, In: Journal of the American Chemical Society. 130, 4, p. 1341-9 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Allosteric activation of coagulation factor VIIa visualized by hydrogen exchange

      Rand, Kasper Dyrberg, Jørgensen, T., Olsen, Ole, Persson, E., Jensen, O., Stennicke, H. R. & Andersen, M., 2006, In: Journal of Biological Chemistry. 281, 32, p. 23018-24 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. The origins of enhanced activity in factor VIIa analogs and the interplay between key allosteric sites revealed by hydrogen exchange mass spectrometry

      Rand, Kasper Dyrberg, Andersen, M., Olsen, O. H., Jørgensen, T., Ostergaard, H., Jensen, O., Stennicke, H. R. & Persson, E., 2008, In: Journal of Biological Chemistry. 283, 19, p. 13378-87 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      ETD in a traveling wave ion guide at tuned Z-spray ion source conditions allows for site-specific hydrogen/deuterium exchange measurements

      Rand, Kasper Dyrberg, Pringle, S. D., Morris, M., Engen, J. R. & Brown, J. M., 2011, In: Journal of The American Society for Mass Spectrometry. 22, 10, p. 1784-1793

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Site-specific analysis of gas-phase hydrogen/deuterium exchange of peptides and proteins by electron transfer dessociation

      Rand, Kasper Dyrberg, Pringle, S. D., Morris, M. & Brown, J. M., 2012, In: Analytical Chemistry. 84, 4, p. 1931-1940

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Loss of ammonia during electron-transfer dissociation of deuterated peptides as an inherent gauge of gas-phase hydrogen scrambling

      Rand, Kasper Dyrberg, Zehl, M., Jensen, O. & Jørgensen, T., 2010, In: Analytical Chemistry. 82, 23, p. 9755-62 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Measuring the hydrogen/deuterium exchange of proteins at high spatial resolution by mass spectrometry: overcoming gas-phase hydrogen/deuterium scrambling

      Rand, Kasper Dyrberg, Zehl, M. & Jørgensen, T. J. D., 21 Oct 2014, In: Accounts of Chemical Research. 47, 10, p. 3018-27 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Revealing the dynamic allosteric changes required for formation of the cysteine synthase complex by hydrogen-deuterium exchange mass spectrometry

      Rosa, B., Dickinson, E. R., Marchetti, M., Campanini, B., Pioselli, B., Bettati, S. & Rand, Kasper Dyrberg, 2021, In: Molecular and Cellular Proteomics. 20, 12 p., 100098.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Unusual Self-Assembly of the Recombinant Chlamydia trachomatis Major Outer Membrane Protein-Based Fusion Antigen CTH522 Into Protein Nanoparticles

      Rose, F., Karlsen, K., Jensen, P. R., Jakobsen, R. U., Wood, G. K., Rand, Kasper Dyrberg, Godiksen, H., Andersen, P., Follmann, F. & Foged, Camilla, Jun 2018, In: Journal of Pharmaceutical Sciences. 107, 6, p. 1690-1700 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      The dopamine transporter antiports potassium to increase the uptake of dopamine

      Schmidt, S. G., Malle, M. G., Nielsen, A. K., Bohr, S. S., Pugh, Ciara Frances, Nielsen, Jeppe Cederholm, Poulsen, I. H., Rand, Kasper Dyrberg, Hatzakis, Nikos & Loland, Claus Juul, 2022, In: Nature Communications. 13, 1, 12 p., 2446.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Probing the Conformational and Functional Consequences of Disulfide Bond Engineering in Growth Hormone by Hydrogen-Deuterium Exchange Mass Spectrometry Coupled to Electron Transfer Dissociation

      Seger, S. T., Breinholt, J., Faber, J. H., Andersen, M. D., Wiberg, C., Schjødt, C. B. & Rand, Kasper Dyrberg, 16 Jun 2015, In: Analytical Chemistry. 87, 12, p. 5973-80 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Epitope mapping of a blood-brain barrier crossing antibody targeting the cysteine-rich region of IGF1R using hydrogen-exchange mass spectrometry enabled by electrochemical reduction

      Sheff, J., Kelly, J., Foss, M., Brunette, E., Kemmerich, K., van Faassen, H., Raphael, S., Hussack, G., Comamala, G., Rand, Kasper Dyrberg & Stanimirovic, D. B., 2023, In: Journal of Biochemistry. 173, 2, p. 95-105

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene

      Singh, H. R., Nardozza, A. P., Möller, I. R., Knobloch, G., Kistemaker, H. A. V., Hassler, M., Harrer, N., Blessing, C., Eustermann, S., Kotthoff, C., Huet, S., Mueller-Planitz, F., Filippov, D. V., Timinszky, G., Rand, Kasper Dyrberg & Ladurner, A. G., 7 Dec 2017, In: Molecular Cell. 68, 5, p. 860-871.e7

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Construct design, production, and characterization of Plasmodium falciparum 48/45 R0.6C subunit protein produced in Lactococcus lactis as candidate vaccine

      Singh, S. K., Roeffen, W., Mistarz, U. H., Chourasia, B. K., Yang, F., Rand, Kasper Dyrberg, Sauerwein, R. W. & Theisen, Michael, 2017, In: Microbial Cell Factories. 16, 1, 11 p., 97.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Sites involved in intra- and interdomain allostery associated with the activation of factor VIIa pinpointed by hydrogen-deuterium exchange and electron transfer dissociation mass spectrometry

      Song, H., Olsen, O. H., Persson, E. & Rand, Kasper Dyrberg, 24 Oct 2014, In: The Journal of Biological Chemistry. 289, p. 35388-96 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Massespektrometri viser vejen til forbedrede proteinlægemidler

      Song, H. & Rand, Kasper Dyrberg, 2012, In: Lægemiddelforskning. 2012, p. 43-46

      Research output: Contribution to journal › Journal article › Communication

    49. Published

      The Impact of the ‘Austrian’ Mutation of the Amyloid Precursor Protein Transmembrane Helix is Communicated to the Hinge Region

      Stelzer, W., Scharnagl, C., Leurs, U., Rand, Kasper Dyrberg & Langosch, D., 2016, In: ChemistrySelect. 1, 15, p. 4408-4412 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      The extraordinary thermal stability of EstA from S. islandicus is independent of post translational modifications

      Stiefler-Jensen, D., Schwarz-Linnet, T., de Lichtenberg, C., Nguyen, T. T. T. N., Rand, Kasper Dyrberg, Huang, L., She, Q. & Teilum, Kaare, Sep 2017, In: Protein Science. 26, 9, p. 1819-1827 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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