Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles

Research output: Contribution to journal › Review › Research › peer-review

Standard

Antibacterial Nanomaterials : Mechanisms, Impacts on Antimicrobial Resistance and Design Principles. / Xie, Maomao; Gao, Meng; Yun, Yang; Malmsten, Martin; Rotello, Vincent M. M.; Zboril, Radek; Akhavan, Omid; Kraskouski, Aliaksandr; Amalraj, John; Cai, Xiaoming; Lu, Jianmei; Zheng, Huizhen; Li, Ruibin.

In: Angewandte Chemie International Edition, Vol. 62, No. 17, e202217345, 2023.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Xie, M, Gao, M, Yun, Y, Malmsten, M, Rotello, VMM, Zboril, R, Akhavan, O, Kraskouski, A, Amalraj, J, Cai, X, Lu, J, Zheng, H & Li, R 2023, 'Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles', Angewandte Chemie International Edition, vol. 62, no. 17, e202217345. https://doi.org/10.1002/anie.202217345

APA

Xie, M., Gao, M., Yun, Y., Malmsten, M., Rotello, V. M. M., Zboril, R., Akhavan, O., Kraskouski, A., Amalraj, J., Cai, X., Lu, J., Zheng, H., & Li, R. (2023). Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles. Angewandte Chemie International Edition, 62(17), [e202217345]. https://doi.org/10.1002/anie.202217345

Vancouver

Xie M, Gao M, Yun Y, Malmsten M, Rotello VMM, Zboril R et al. Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles. Angewandte Chemie International Edition. 2023;62(17). e202217345. https://doi.org/10.1002/anie.202217345

Author

Xie, Maomao ; Gao, Meng ; Yun, Yang ; Malmsten, Martin ; Rotello, Vincent M. M. ; Zboril, Radek ; Akhavan, Omid ; Kraskouski, Aliaksandr ; Amalraj, John ; Cai, Xiaoming ; Lu, Jianmei ; Zheng, Huizhen ; Li, Ruibin. / Antibacterial Nanomaterials : Mechanisms, Impacts on Antimicrobial Resistance and Design Principles. In: Angewandte Chemie International Edition. 2023 ; Vol. 62, No. 17.

Bibtex

@article{60deb5e14d544b20a16eb595ac776fd7,
title = "Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles",
abstract = "Antimicrobial resistance (AMR) is one of the biggest threats to the environment and health. AMR rapidly invalidates conventional antibiotics, and antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several antimicrobial nanomaterials show AMR-independent antimicrobial effects without detectable new resistance and have therefore been suggested to prevent AMR evolution. In contrast, some are found to trigger the evolution of AMR. Given these seemingly conflicting findings, a timely discussion of the two faces of antimicrobial nanomaterials is urgently needed. This review systematically compares the killing mechanisms and structure-activity relationships of antibiotics and antimicrobial nanomaterials. We then focus on nano-microbe interactions to elucidate the impacts of molecular initiating events on AMR evolution. Finally, we provide an outlook on future antimicrobial nanomaterials and propose design principles for the prevention of AMR evolution.",
keywords = "Antibacterial Nanomaterials, Antimicrobial Resistance, Killing Mechanism, Nano-Bio Interaction, Structure-Activity Relationship, SNAPSHOT ANTIBIOTIC INHIBITION, BACTERIAL-CELL DIVISION, GRAPHENE OXIDE, SILVER NANOPARTICLES, GOLD NANOPARTICLES, DEPENDENT ANTIBACTERIAL, ENHANCED ANTIBACTERIAL, HORIZONTAL TRANSFER, ZNO NANOPARTICLES, COPPER NANOPARTICLES",
author = "Maomao Xie and Meng Gao and Yang Yun and Martin Malmsten and Rotello, {Vincent M. M.} and Radek Zboril and Omid Akhavan and Aliaksandr Kraskouski and John Amalraj and Xiaoming Cai and Jianmei Lu and Huizhen Zheng and Ruibin Li",
year = "2023",
doi = "10.1002/anie.202217345",
language = "English",
volume = "62",
journal = "Angewandte Chemie International Edition",
issn = "1433-7851",
publisher = "Wiley-VCH Verlag GmbH & Co. KGaA",
number = "17",

}

RIS

TY - JOUR

T1 - Antibacterial Nanomaterials

T2 - Mechanisms, Impacts on Antimicrobial Resistance and Design Principles

AU - Xie, Maomao

AU - Gao, Meng

AU - Yun, Yang

AU - Malmsten, Martin

AU - Rotello, Vincent M. M.

AU - Zboril, Radek

AU - Akhavan, Omid

AU - Kraskouski, Aliaksandr

AU - Amalraj, John

AU - Cai, Xiaoming

AU - Lu, Jianmei

AU - Zheng, Huizhen

AU - Li, Ruibin

PY - 2023

Y1 - 2023

N2 - Antimicrobial resistance (AMR) is one of the biggest threats to the environment and health. AMR rapidly invalidates conventional antibiotics, and antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several antimicrobial nanomaterials show AMR-independent antimicrobial effects without detectable new resistance and have therefore been suggested to prevent AMR evolution. In contrast, some are found to trigger the evolution of AMR. Given these seemingly conflicting findings, a timely discussion of the two faces of antimicrobial nanomaterials is urgently needed. This review systematically compares the killing mechanisms and structure-activity relationships of antibiotics and antimicrobial nanomaterials. We then focus on nano-microbe interactions to elucidate the impacts of molecular initiating events on AMR evolution. Finally, we provide an outlook on future antimicrobial nanomaterials and propose design principles for the prevention of AMR evolution.

AB - Antimicrobial resistance (AMR) is one of the biggest threats to the environment and health. AMR rapidly invalidates conventional antibiotics, and antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several antimicrobial nanomaterials show AMR-independent antimicrobial effects without detectable new resistance and have therefore been suggested to prevent AMR evolution. In contrast, some are found to trigger the evolution of AMR. Given these seemingly conflicting findings, a timely discussion of the two faces of antimicrobial nanomaterials is urgently needed. This review systematically compares the killing mechanisms and structure-activity relationships of antibiotics and antimicrobial nanomaterials. We then focus on nano-microbe interactions to elucidate the impacts of molecular initiating events on AMR evolution. Finally, we provide an outlook on future antimicrobial nanomaterials and propose design principles for the prevention of AMR evolution.

KW - Antibacterial Nanomaterials

KW - Antimicrobial Resistance

KW - Killing Mechanism

KW - Nano-Bio Interaction

KW - Structure-Activity Relationship

KW - SNAPSHOT ANTIBIOTIC INHIBITION

KW - BACTERIAL-CELL DIVISION

KW - GRAPHENE OXIDE

KW - SILVER NANOPARTICLES

KW - GOLD NANOPARTICLES

KW - DEPENDENT ANTIBACTERIAL

KW - ENHANCED ANTIBACTERIAL

KW - HORIZONTAL TRANSFER

KW - ZNO NANOPARTICLES

KW - COPPER NANOPARTICLES

U2 - 10.1002/anie.202217345

DO - 10.1002/anie.202217345

M3 - Review

C2 - 36718001

VL - 62

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

SN - 1433-7851

IS - 17

M1 - e202217345

ER -

ID: 339617669