Surface and Colloid Chemistry
The goal of the Surface and Colloid Chemistry Group is to advance the knowledge of interactions of host defense peptides and nanomaterial carriers, with membranes and membrane components of cells and bacteria. Through this, as well as innovative approaches for performing such studies, the aim is to translate our research into further therapeutic development.
The Surface and Colloid Chemistry Group focuses its research on physicochemical aspects of drug delivery, particularly for amphiphilic host defense peptides and nanoparticulate delivery systems. For these systems, we employ a range of surface and colloid chemistry techniques, including ATR-FTIR, QCM-D, SAXS, and light scattering. In addition, we have expanded our research to include neutron scattering, mainly neutron reflection but also SANS, e.g., for studies of the interactions of amphiphilic peptides and nanoparticulate delivery systems with model lipid membranes. Such physicochemical studies are matched with biological experiments so that key structural and dynamic issues determining the biological performance of systems can be elucidated. “Our vision is to provide the mechanistic foundation to further the much needed development of novel peptide therapeutics in this age of emerging resistance of bacteria towards conventional antibiotics,” says Martin Malmsten.
Membrane Interactions and Antimicrobial Effects of Layered Double Hydroxide Nanoparticles
Through binding and extraction of anionic lipids, layered double hydroxide (LDH) result in membrane destabilization and antimicrobial effects. In addition, LDH cause flocculation of bacteria, effects of potential importance for the confinement of infection and inflammation.
High Content Packing of Antimicrobial Peptides in Polymer Microgels
Combining NMR with a battery of physicochemical methods and biological assays, this study demonstrates that peptide loading, packing, and release affect the performance of microgels as delivery systems for antimicrobial peptides (AMP), tunable by peptide amphiphilicity and microgel charge density.
Structural Basis of Endotoxin Neutralization and Anti-Inflammatory Activity of Thrombin-Derived C-Terminal Peptides
By combining NMR, biophysical, and cellular studies with multiscale modeling, this study demonstrates the role of structural transitions in lipopolysaccharide complex formation and CD14 interaction, providing a molecular explanation for therapeutic effects of thrombin-derived AMPs in bacterial sepsis and endotoxin shock models.
Staff at Surface and Colloid Chemistry
Group Leader: Martin Malmsten