Drug Use among Nursing Home Residents in Denmark for Drugs Having Pharmacogenomics Based (PGx) Dosing Guidelines: Potential for Preemptive PGx Testing

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Drug Use among Nursing Home Residents in Denmark for Drugs Having Pharmacogenomics Based (PGx) Dosing Guidelines : Potential for Preemptive PGx Testing. / Vermehren, Charlotte; Nielsen, Regitze Sogaard; Jorgensen, Steffen; Drastrup, Anne Mette; Westergaard, Niels.

In: Journal of Personalized Medicine, Vol. 10, No. 3, 78, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Vermehren, C, Nielsen, RS, Jorgensen, S, Drastrup, AM & Westergaard, N 2020, 'Drug Use among Nursing Home Residents in Denmark for Drugs Having Pharmacogenomics Based (PGx) Dosing Guidelines: Potential for Preemptive PGx Testing', Journal of Personalized Medicine, vol. 10, no. 3, 78. https://doi.org/10.3390/jpm10030078

APA

Vermehren, C., Nielsen, R. S., Jorgensen, S., Drastrup, A. M., & Westergaard, N. (2020). Drug Use among Nursing Home Residents in Denmark for Drugs Having Pharmacogenomics Based (PGx) Dosing Guidelines: Potential for Preemptive PGx Testing. Journal of Personalized Medicine, 10(3), [78]. https://doi.org/10.3390/jpm10030078

Vancouver

Vermehren C, Nielsen RS, Jorgensen S, Drastrup AM, Westergaard N. Drug Use among Nursing Home Residents in Denmark for Drugs Having Pharmacogenomics Based (PGx) Dosing Guidelines: Potential for Preemptive PGx Testing. Journal of Personalized Medicine. 2020;10(3). 78. https://doi.org/10.3390/jpm10030078

Author

Vermehren, Charlotte ; Nielsen, Regitze Sogaard ; Jorgensen, Steffen ; Drastrup, Anne Mette ; Westergaard, Niels. / Drug Use among Nursing Home Residents in Denmark for Drugs Having Pharmacogenomics Based (PGx) Dosing Guidelines : Potential for Preemptive PGx Testing. In: Journal of Personalized Medicine. 2020 ; Vol. 10, No. 3.

Bibtex

@article{5eed2bbaae2a467792599a28aa446d80,
title = "Drug Use among Nursing Home Residents in Denmark for Drugs Having Pharmacogenomics Based (PGx) Dosing Guidelines: Potential for Preemptive PGx Testing",
abstract = "Background: Polypharmacy is most prevalent among the elderly population and in particular among nursing home residents. The frequency of the use of drugs with pharmacogenomics (PGx)-based dosing guidelines for CYP2D6, CYP2C9, CYP2C19 and SLCO1B1 were measured among nursing home residents in the Capital Region of Denmark as well as drug-drug interactions. The aim was to evaluate the potential of applying PGx-test as a supportive tool in medication reviews. Methods: Drug use among nursing home residents during 2017-2018 in the Capital Region of Copenhagen, for drugs with PGx-based dosing guidelines available through the PharmGKB website, were measured. Drug-drug interactions were scored in severity by using drug interaction checkers. Results: The number of residents using drugs with PGx-based actionable dosing guidelines (AG) were 119 out of 141 residents (84.3%). Of these 119 residents, 87 residents used drugs with AG for CYP2C19, 47 residents for CYP2D6, and 42 residents for SLCO1B1. In addition, 30 residents used two drugs with an AG for CYP2C19, and for CYP2D6, it was only seven residents. The most used drugs with AG were clopidogrel (42), pantoprazole (32), simvastatin (30), metoprolol (25), and citalopram (24). The most frequent drug interactions found with warnings were combinations of proton pump inhibitors and clopidogrel underscoring the potential for phenoconversion. Conclusion: this study clearly showed that the majority of the nursing home residents were exposed to drugs or drug combinations for which there exist PGx-based AG. This indeed supports the notion of accessing and accounting for not only drug-gene but also drug-drug-gene interactions as a supplement to medication review.",
keywords = "nursing homes, polypharmacy, medicine review, pharmacogenomics, cytochrome P450, drug-drug interactions, drug-gene interactions, drug use, PGx testing, CYP2C19, CYP2D6, GENE",
author = "Charlotte Vermehren and Nielsen, {Regitze Sogaard} and Steffen Jorgensen and Drastrup, {Anne Mette} and Niels Westergaard",
year = "2020",
doi = "10.3390/jpm10030078",
language = "English",
volume = "10",
journal = "Journal of Personalized Medicine",
issn = "2075-4426",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

RIS

TY - JOUR

T1 - Drug Use among Nursing Home Residents in Denmark for Drugs Having Pharmacogenomics Based (PGx) Dosing Guidelines

T2 - Potential for Preemptive PGx Testing

AU - Vermehren, Charlotte

AU - Nielsen, Regitze Sogaard

AU - Jorgensen, Steffen

AU - Drastrup, Anne Mette

AU - Westergaard, Niels

PY - 2020

Y1 - 2020

N2 - Background: Polypharmacy is most prevalent among the elderly population and in particular among nursing home residents. The frequency of the use of drugs with pharmacogenomics (PGx)-based dosing guidelines for CYP2D6, CYP2C9, CYP2C19 and SLCO1B1 were measured among nursing home residents in the Capital Region of Denmark as well as drug-drug interactions. The aim was to evaluate the potential of applying PGx-test as a supportive tool in medication reviews. Methods: Drug use among nursing home residents during 2017-2018 in the Capital Region of Copenhagen, for drugs with PGx-based dosing guidelines available through the PharmGKB website, were measured. Drug-drug interactions were scored in severity by using drug interaction checkers. Results: The number of residents using drugs with PGx-based actionable dosing guidelines (AG) were 119 out of 141 residents (84.3%). Of these 119 residents, 87 residents used drugs with AG for CYP2C19, 47 residents for CYP2D6, and 42 residents for SLCO1B1. In addition, 30 residents used two drugs with an AG for CYP2C19, and for CYP2D6, it was only seven residents. The most used drugs with AG were clopidogrel (42), pantoprazole (32), simvastatin (30), metoprolol (25), and citalopram (24). The most frequent drug interactions found with warnings were combinations of proton pump inhibitors and clopidogrel underscoring the potential for phenoconversion. Conclusion: this study clearly showed that the majority of the nursing home residents were exposed to drugs or drug combinations for which there exist PGx-based AG. This indeed supports the notion of accessing and accounting for not only drug-gene but also drug-drug-gene interactions as a supplement to medication review.

AB - Background: Polypharmacy is most prevalent among the elderly population and in particular among nursing home residents. The frequency of the use of drugs with pharmacogenomics (PGx)-based dosing guidelines for CYP2D6, CYP2C9, CYP2C19 and SLCO1B1 were measured among nursing home residents in the Capital Region of Denmark as well as drug-drug interactions. The aim was to evaluate the potential of applying PGx-test as a supportive tool in medication reviews. Methods: Drug use among nursing home residents during 2017-2018 in the Capital Region of Copenhagen, for drugs with PGx-based dosing guidelines available through the PharmGKB website, were measured. Drug-drug interactions were scored in severity by using drug interaction checkers. Results: The number of residents using drugs with PGx-based actionable dosing guidelines (AG) were 119 out of 141 residents (84.3%). Of these 119 residents, 87 residents used drugs with AG for CYP2C19, 47 residents for CYP2D6, and 42 residents for SLCO1B1. In addition, 30 residents used two drugs with an AG for CYP2C19, and for CYP2D6, it was only seven residents. The most used drugs with AG were clopidogrel (42), pantoprazole (32), simvastatin (30), metoprolol (25), and citalopram (24). The most frequent drug interactions found with warnings were combinations of proton pump inhibitors and clopidogrel underscoring the potential for phenoconversion. Conclusion: this study clearly showed that the majority of the nursing home residents were exposed to drugs or drug combinations for which there exist PGx-based AG. This indeed supports the notion of accessing and accounting for not only drug-gene but also drug-drug-gene interactions as a supplement to medication review.

KW - nursing homes

KW - polypharmacy

KW - medicine review

KW - pharmacogenomics

KW - cytochrome P450

KW - drug-drug interactions

KW - drug-gene interactions

KW - drug use

KW - PGx testing

KW - CYP2C19

KW - CYP2D6

KW - GENE

U2 - 10.3390/jpm10030078

DO - 10.3390/jpm10030078

M3 - Journal article

C2 - 32752034

VL - 10

JO - Journal of Personalized Medicine

JF - Journal of Personalized Medicine

SN - 2075-4426

IS - 3

M1 - 78

ER -

ID: 250599007