Antibiotic Drug use – University of Copenhagen


Antibiotic Drug use, Monitoring and Evaluation of Resistance in Ghana

Diseases of bacterial origin are a major cause of morbidity and mortality in low-income countries, like Ghana. Antibiotics are still the main therapy for many of these diseases.

In Ghana, antibiotics are available to the public from a variety of sources, including hospitals and pharmacies; licensed medicine stalls and drugstores; markets and roadside stalls and hawkers. They are commonly purchased without a prescription, even when this practice is illegal. This widespread availability has led to inappropriate use by patients and health care providers, and a steady increase in drug resistance. However, the magnitude and determinants of the impact of resistance on human health is unknown.

We monitor potency and quality of drugs using already developed HPLC and LC-MS/MS methods. Furthermore we analyse antibiotics in hospitalised patients in association with studies on antimicrobial resistance. Urine and blood serum samples are obtained from patients on antibiotic treatment to measure concentrations of administered antibiotics and their metabolites.

Results obtained are used to assess quality of consumed antibiotics and dosing regimens to prevent antimicrobial resistance.

Field work is conducted in Ghana, Africa.