Selenium Metabolism – University of Copenhagen

Selenium Metabolism

Selenium (Se) is a cancer-preventive element in low doses while high Se doses have shown to effectively kill human tumor cells. Low Molecular weight (LMW) Se compounds and their metabolic products are believed to play an important role in the cancer-preventive and therapeutic effects.
The underlying chemistry and metabolic pathways of the effects is not fully understood as most data on Se from animal studies and clinical trials only include total selenium determination.

In our research, we use advanced analytical methods to identify and quantify the LMW selenium species in samples from biological fluids, tissues, cell models and samples from clinical studies as well as samples from animal studies on the influence of obesity on cancer prevention.
By mapping the Se metabolism in these studies and combining the information, we obtain information on mechanisms and interactions that may be beneficial for future development of new cancer prevention and cancer treatment schemes.