Metal-based Drugs – University of Copenhagen

Metal-based Drugs

Platinum drugs are widely used for treatment of solid tumors and more than 50% of all cancer patients are treated with platinum drugs.
However, adverse effects and resistance limits their therapeutic potential.

Cisplatin, Oxaliplatin and Carboplatin are the most often applied drugs in the clinic, but during the last 20 years hundreds of other metal-based drugs (Pt, Au, Ru etc.) have been synthesized and investigated, several of these have entered clinical trials.

The mode of action for most of these drugs is similar to that of cisplatin ie. they are given intravenously, taken up by the cancer cells and accumulate inside the cancer cell where they bind to DNA and induce cell death.

The aim of our research is to develop and apply advanced analytical methods to investigate the fate of metal-based drugs and drug delivery systems in biological systems e.g. serum, cancer cell lines, or tissue models. The analytical methods are based on ICPMS, MS and HPLC technology.