High-resolution mass spectrometry imaging as a molecule-specific microscopy tool to study disease progression and drug delivery in tissue samples – University of Copenhagen

  

High-resolution mass spectrometry imaging as a molecule-specific microscopy tool to study disease progression and drug delivery in tissue samples


New developments in mass spectrometry imaging (MSI) make it possible to visualize phenomena at the microscopic level, together with all the chemical identification and specificity which mass spectrometry provides.

We wish to use this revolutionary technological advance for two specific projects:

1) To study selected biochemical processes related to brain ischemia by identifying and localizing the many lipids species which are involved, both as cell constituents in the different phases of ischemia, and as signaling molecules.
2) Fundamental studies of penetration enhancers in drug delivery. MSI at the cellular level will reveal histological features of biological tissue (different cell types in different regions) as in normal microscopy, but on top of these images, we are also specifically mapping the distribution of the penetration enhancer and the delivered drug.

This level of histological and chemical information is uniquely available with high-resolution MSI.