Polymeric pharmaceutical excipients – University of Copenhagen

Polymeric pharmaceutical excipients

This project focuses on the use of different polymers as pharmaceutical excipients.
This can be subdivided into the work on the use of polymers in the formulation and processing of small molecular APIs and therapeutically active protein substances.
Crystal engineering of small molecular APIs can influence among others the solubility behavior.

Design of polymeric particles as carriers for various drug molecules is also including various polymeric excipients that can be tuned to modify the release properties of the system. The notorious instability of therapeutically active protein molecules is a challenge for pharmacists so that this type of drugs can be utilized to the fullest. The stability can be affected by the adsorption to various interfaces and the liquid-liquid interfacial adsorption can be monitored with interfacial rheological measurements showing clearly the viscoelastic layer that aggregated proteins have at the interface.

Another way of stabilizing proteins is to use the newly invented nanogels as carriers that can protect the protein from denaturation and aggregation during all stages of manufacturing, i.e. formulation, processing, storage and final administration.
By the strategic choice and/or design of the polymer excipients used in the above mentioned cases the product can be tuned to have the desired profile in each and every case, and thus is crucial in the design of a drug delivery system.

Recent projects within this field: Nitrofurantoin crystal modification in the presence of poly(N-isopropylacrylamide) The hindering of protein adsorption to oil-water interfaces in the presence of polyelectrolytes Nanogel design for the improvement of protein stability during manufacturing.