Physiological Pharmaceutics

  1. 2024
  2. Published

    Binder jetting 3D printing in fabricating pharmaceutical solid products for precision medicine

    Wang, Y., Genina, Natalja, Mullertz, Anette & Rantanen, Jukka, 2024, In: Basic & clinical pharmacology & toxicology. 134, 3, p. 325-332

    Research output: Contribution to journalReviewpeer-review

  3. Published

    Comparison of the liquisolid technique and co-milling for loading of a poorly soluble drug in inorganic porous excipients

    Ogadah, C. U., Mrštná, K., Matysová, L., Mullertz, Anette , Rades, Thomas, Niederquell, A., Šklubalová, Z. & Vraníková, B., 2024, In: International Journal of Pharmaceutics. 650, 10 p., 123702.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Effect of Drug Loading in Mesoporous Silica on Amorphous Stability and Performance

    Bavnhøj, C. G., Knopp, M. M. & Löbmann, K., 2024, In: Pharmaceutics. 16, 2, 11 p., 163.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    Influence of preparation method and choice of phospholipid on co-amorphization, physical stability, and dissolution behavior of equimolar indomethacin-phospholipid systems: A case study

    Khorami, Keyoomars, Mullertz, Anette & Rades, Thomas, 2024, In: Journal of Drug Delivery Science and Technology. 93, 8 p., 105433.

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    The interplay between trehalose and dextran as spray drying precursors for cationic liposomes

    Lutta, A., Knopp, M. M., Tollemeto, M., Pedersen, G. K., Schmidt, S. T., Grohganz, Holger & Hagner Nielsen, L., 2024, In: International Journal of Pharmaceutics. 652, 10 p., 123798.

    Research output: Contribution to journalJournal articlepeer-review

  7. 2023
  8. Published

    In vitro-in vivo relationship for amorphous solid dispersions using a double membrane dissolution-permeation setup

    Jørgensen, J. R., Mohr, W., Rischer, M., Sauer, A., Mistry, S., Rades, Thomas & Mullertz, Anette , 2023, In: European Journal of Pharmaceutics and Biopharmaceutics. 188, p. 26-32

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    Amphotericin B and monoacyl-phosphatidylcholine form a stable amorphous complex

    Liu, X., Berthelsen, R., Bar-Shalom, Daniel, Kjellerup Lind, T., Doutch, J. & Mullertz, Anette , 2023, In: International Journal of Pharmaceutics. 633, 10 p., 122601.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Assessing acute colitis induced by dextran sulfate sodium in rats and its impact on gastrointestinal fluids

    Klitgaard, Mette, Kristensen, M. N., Venkatasubramanian, R., Guerra, Priscila Regina, Jacobsen, Jette, Berthelsen, R., Rades, Thomas & Mullertz, Anette , 2023, In: Drug Delivery and Translational Research. 13, p. 1484–1499

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Biorelevant Dissolution of Dipyridamole and Piroxicam Using an Automated UV/Vis Spectrophotometric and Potentiometric Dissolution Testing Platform

    Berthelsen, R., Larsen, Susan Weng, Mullertz, Anette , Box, K. & Østergaard, Jesper, 2023, In: Dissolution Technologies. 30, 3, p. 144-153

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    Coating of Primary Powder Particles Improves the Quality of Binder Jetting 3D Printed Oral Solid Products

    Wang, Y., Genina, Natalja, Mullertz, Anette & Rantanen, Jukka, 2023, In: Journal of Pharmaceutical Sciences. 112, 2, p. 506-512

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    Design and Optimization of a Nanoparticulate Pore Former as a Multifunctional Coating Excipient for pH Transition-Independent Controlled Release of Weakly Basic Drugs for Oral Drug Delivery

    Chang, H. H. R., Chen, K., Lugtu-Pe, J. A., AL-Mousawi, N., Zhang, X., Bar-Shalom, Daniel, Kane, A. & Wu, X. Y., 2023, In: Pharmaceutics. 15, 2, 21 p., 547.

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    Functionalized calcium carbonate (FCC) as a novel carrier to solidify supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS)

    Merchant, J., Mullertz, Anette , Rades, Thomas & Bannow, J., 2023, In: European Journal of Pharmaceutics and Biopharmaceutics. 193, p. 198-207

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Moving perfusion culture and live-cell imaging from lab to disc: proof of concept toxicity assay with AI-based image analysis

    Serioli, L., Gruzinskyte, L., Zappalà, G., Hwu, E. T., Laksafoss, T. Z., Jensen, P. L., Demarchi, D., Mullertz, Anette , Boisen, A. & Zór, K., 2023, In: Lab on a Chip. 23, p. 1603-1612

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Mucoadhesive chitosan- and cellulose derivative-based nanofiber-on-foam-on-film system for non-invasive peptide delivery

    Stie, Mai Bay, Öblom, H., Hansen, Anders Christian Nørgaard, Jacobsen, Jette, Chronakis, I. S., Rantanen, Jukka, Nielsen, Hanne Mørck & Genina, Natalja, 2023, In: Carbohydrate Polymers. 303, 120429.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Stability and intrinsic dissolution of vacuum compression molded amorphous solid dispersions of efavirenz

    Jørgensen, J. R., Mohr, W., Rischer, M., Sauer, A., Mistry, S., Mullertz, Anette & Rades, Thomas, 2023, In: International Journal of Pharmaceutics. 632, 8 p., 122564.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    The Influence of Blonanserin Supersaturation in Liquid and Silica Stabilised Self-Nanoemulsifying Drug Delivery Systems on In Vitro Solubilisation

    Møller, Amalie Lykkemark, Schultz, H. B., Meola, T. R., Joyce, P., Mullertz, Anette & Prestidge, C. A., 2023, In: Pharmaceutics. 15, 1, 14 p., 284.

    Research output: Contribution to journalJournal articlepeer-review

  19. 2022
  20. Published

    UNGAP best practice for improving solubility data quality of orally administered drugs

    Vertzoni, M., Alsenz, J., Augustijns, P., Bauer-Brandl, A., Bergström, C. A. S., Brouwers, J., Mullertz, Anette , Perlovich, G., Saal, C., Sugano, K. & Reppas, C., 1 Jan 2022, In: European Journal of Pharmaceutical Sciences. 168, 21 p., 106043.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    Additive Manufacturing of Solid Products for Oral Drug Delivery Using Binder Jetting Three-Dimensional Printing

    Wang, Y., Mullertz, Anette & Rantanen, Jukka, 2022, In: AAPS PharmSciTech. 23, 6, 196.

    Research output: Contribution to journalReviewpeer-review

  22. Published
  23. Published

    Combining lipid based drug delivery and amorphous solid dispersions for improved oral drug absorption of a poorly water-soluble drug

    Nora, G., Venkatasubramanian, R., Strindberg, S., Siqueira-Jørgensen, S. D., Pagano, L., Romanski, F. S., Swarnakar, N. K., Rades, Thomas & Mullertz, Anette , 2022, In: Journal of Controlled Release. 349, p. 206-212

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    Development of a Microgram Scale Video-Microscopic Method to Investigate Dissolution Behavior of Poorly Water-Soluble Drugs

    Senniksen, M. B., Christfort, J. F., Marabini, R., Spillum, E., Matthews, W., Da Vià, L., Plum, J., Rades, Thomas & Mullertz, Anette , 2022, In: AAPS PharmSciTech. 23, 6, 173.

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    Direct visualizing of paracetamol immediate release tablet disintegration in vivo and in vitro

    Fredholt, Freja, Di Meo, C., Sloth, S., Mullertz, Anette & Berthelsen, R., 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 180, p. 63-70

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    Elucidating Pathway and Anesthetic Mechanism of Action of Clove Oil Nanoformulations in Fish

    Kheawfu, K., Pikulkaew, S., Wellendorph, Petrine, Jørgensen, Louise von Gersdorff, Rades, Thomas, Mullertz, Anette & Okonogi, S., 2022, In: Pharmaceutics. 14, 5, 13 p., 919.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Formulation, characterization and in-vitro evaluation of self-nanoemulsifying drug delivery system containing rhamnolipid biosurfactant

    Khan, Muhammad Ayub, Ullah, K., Rahman, N. U., Mahmood, A., Mullertz, Anette , Mannan, A., Murtaza, G. & Khan, S. A., 2022, In: Journal of Drug Delivery Science and Technology. 75, 9 p., 103673.

    Research output: Contribution to journalJournal articlepeer-review

  28. Published
  29. Published
  30. Published

    Impact of Molecular Surface Diffusion on the Physical Stability of Co-Amorphous Systems

    Liu, J., Hwu, E., Bannow, J., Grohganz, Holger & Rades, Thomas, 2022, In: Molecular Pharmaceutics. 19, 4, p. 1183-1190

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    Impact of oral gavage technique of drug-containing microcontainers on the gastrointestinal transit and absorption in rats

    Kristensen, M. N., Rades, Thomas, Boisen, A. & Mullertz, Anette , 2022, In: International Journal of Pharmaceutics. 618, 121630.

    Research output: Contribution to journalJournal articlepeer-review

  32. Published

    In vitro and ex vivo evaluation of bilayered effervescent microenvironmental pH modifying buccal films with saquinavir

    He, S., Nielsen, C. U., Mu, Huiling & Jacobsen, Jette, 2022, In: Journal of Drug Delivery Science and Technology. 78, 7 p., 103954.

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    Introducing a Novel Biorelevant In Vitro Dissolution Method for the Assessment of Nicotine Release from Oral Tobacco-Derived Nicotine (OTDN) and Snus Products

    Knopp, M. M., Kiil-Nielsen, N. K., Masser, A. E. & Staaf, M., 2022, In: Separations. 9, 2, 8 p., 52.

    Research output: Contribution to journalJournal articlepeer-review

  34. Published
  35. Published

    Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin

    Stie, Mai Bay, Gätke, J. R., Chronakis, I. S., Jacobsen, Jette & Nielsen, Hanne Mørck, 2022, In: International Journal of Molecular Sciences. 23, 3, 9 p., 1458.

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    Physico-chemical characterization of aspirated and simulated human gastric fluids to study their influence on the intrinsic dissolution rate of cinnarizine

    Pedersen, P. B., Berthelsen, R., Rades, Thomas, Jørgensen, S. A., Vilmann, Peter, Bar-Shalom, Daniel, Baldursdottir, S. & Mullertz, Anette , 2022, In: International Journal of Pharmaceutics. 622, 7 p., 121856.

    Research output: Contribution to journalJournal articlepeer-review

  37. Published

    Structured approach for designing drug-loaded solid products by binder jetting 3D printing

    Wang, Y., Mullertz, Anette & Rantanen, Jukka, 2022, In: European Journal of Pharmaceutical Sciences. 178, 11 p., 106280.

    Research output: Contribution to journalJournal articlepeer-review

  38. Published

    The Binding of Alpinia galanga Oil and Its Nanoemulsion to Mammal GABA(A) Receptors Using Rat Cortical Membranes and an In Silico Modeling Platform

    Khumpirapang, N., Suknuntha, K., Wongrattanakamon, P., Jiranusornkul, S., Anuchapreeda, S., Wellendorph, Petrine, Mullertz, Anette , Rades, Thomas & Okonogi, S., 2022, In: Pharmaceutics. 14, 3, 15 p., 650.

    Research output: Contribution to journalJournal articlepeer-review

  39. Published

    The physicochemical properties of preserved and preservative-free latanoprost eye drops and their impact on human conjunctival goblet cells

    Müllertz, O. A. O., Nagstrup, Anne Hedengran, Mouhammad, Zaynab Ahmad, Freiberg, Josefine, Nagymihály, R., Jacobsen, Jette, Larsen, Susan Weng, Bair, J. A., Utheim, T. P., Dartt, D. A., Heegaard, Steffen, Petrovski, G. & Kolko, Miriam, 2022, In: Acta Ophthalmologica. 100, S267

    Research output: Contribution to journalConference abstract in journalpeer-review

  40. 2021
  41. Published

    The effect of the molecular weight of polyvinylpyrrolidone and the model drug on laser-induced in situ amorphization

    Hempel, N. J., Merkl, P., Knopp, M. M., Berthelsen, R., Teleki, A., Hansen, A. K., Sotiriou, G. A. & Löbmann, K., Jul 2021, In: Molecules. 26, 13, 13 p., 4035.

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    Oligonucleotide Delivery across the Caco-2 Monolayer: The Design and Evaluation of Self-Emulsifying Drug Delivery Systems (SEDDS)

    Kubackova, J., Holas, O., Zbytovska, J., Vranikova, B., Zeng, G., Pavek, P. & Mullertz, Anette , Apr 2021, In: Pharmaceutics. 13, 4, 27 p., 459.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    In vitro and in vivo comparison of microcontainers and microspheres for oral drug delivery

    Christfort, J. F., Strindberg, S., Al-khalili, S., Bar-Shalom, Daniel, Boisen, A., Nielsen, L. H. & Mullertz, Anette , 2021, In: International Journal of Pharmaceutics. 600, 9 p., 120516.

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    Bovine Milk-Derived Emulsifiers Increase Triglyceride Absorption in Newborn Formula-Fed Pigs

    Knudsen, K. B. K., Heerup, C., Jensen, T. R. S., Geng, X., Drachmann, N., Nordby, P., Jeppesen, Palle Bekker, Ifaoui, I., Mullertz, Anette , Sangild, Per Torp, Ostenfeld, M. S. & Thymann, Thomas, 2021, In: Nutrients. 13, 2, 15 p., 410.

    Research output: Contribution to journalJournal articlepeer-review

  45. Published

    Controlling the fractal dimension in self-assembly of terpyridine modified insulin by Fe2+ and Eu3+ to direct in vivo effects

    Mishra, N. K., Østergaard, M., Midtgaard, S. R., Strindberg, S. S., Winkler, S., Wu, S., Sørensen, Thomas Just, Hassenkam, Tue, Poulsen, Jens-Christian Navarro, Lo Leggio, Leila, Nielsen, Hanne Mørck, Arleth, Lise, Christensen, Niels Johan, Thulstrup, Peter Waaben & Jensen, Knud Jørgen, 2021, In: Nanoscale. 13, 18, p. 8467–8473 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  46. Published

    Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

    Vinarov, Z., Abrahamsson, B., Artursson, P., Batchelor, H., Berben, P., Bernkop-Schnurch, A., Butler, J., Ceulemans, J., Davies, N., Dupont, D., Flaten, G. E., Fotaki, N., Griffin, B. T., Jannin, V., Keemink, J., Kesisoglou, F., Koziolek, M., Kuentz, M., Mackie, A., Melendez-Martinez, A. J. & 16 others, McAllister, M., Mullertz, Anette , O'Driscoll, C. M., Parrott, N., Paszkowska, J., Pavek, P., Porter, C. J. H., Reppas, C., Stillhart, C., Sugano, K., Toader, E., Valentova, K., Vertzoni, M., De Wildt, S. N., Wilson, C. G. & Augustijns, P., 2021, In: Advanced Drug Delivery Reviews. 171, p. 289-331 43 p.

    Research output: Contribution to journalReviewpeer-review

  47. Published

    Dairy-derived emulsifiers in infant formula show marginal effects on the plasma lipid profile and brain structure in preterm piglets relative to soy lecithin

    Henriksen, Nicole Lind, Aasmul-Olsen, Karoline, Venkatasubramanian, R., Nygaard, M. K. E., Sprenger, R. R., Heckmann, A. B., Ostenfeld, M. S., Ejsing, C. S., Eskildsen, S. F., Mullertz, Anette , Sangild, Per Torp, Bering, Stine Brandt & Thymann, Thomas, 2021, In: Nutrients. 13, 3, p. 1-18 18 p., 718.

    Research output: Contribution to journalJournal articlepeer-review

  48. Published

    Design and optimization of self-nanoemulsifying drug delivery systems of clove oil for efficacy enhancement in fish anesthesia

    Kheawfu, Pikulkaew, Rades, Thomas, Mullertz, Anette , Jørgensen, Louise von Gersdorff & Okonogi, 2021, In: Journal of Drug Delivery Science and Technology. 61, 9 p., 102241.

    Research output: Contribution to journalJournal articlepeer-review

  49. Published

    Design of a self-unfolding delivery concept for oral administration of macromolecules

    Jørgensen, J. R., Thamdrup, L. H. E., Kamguyan, K., Nielsen, L. H., Nielsen, Hanne Mørck, Boisen, A., Rades, Thomas & Mullertz, Anette , 2021, In: Journal of Controlled Release. 329, p. 948-954

    Research output: Contribution to journalJournal articlepeer-review

  50. Published

    Development of Self-Nanoemulsifying Drug Delivery Systems Containing 4-Allylpyrocatechol for Treatment of Oral Infections Caused by Candida albicans

    Okonogi, S., Phumat, P., Khongkhunthian, S., Chaijareenont, P., Rades, Thomas & Mullertz, Anette , 2021, In: Pharmaceutics. 13, 2, 16 p., 167.

    Research output: Contribution to journalJournal articlepeer-review

  51. Published

    Development of gastro-resistant coated probiotic granulates and evaluation of viability and release during simulated upper gastrointestinal transit

    Jacobsen, N. M. Y., Nedergaard, H. B., Kock, A., Caglayan, I., Laursen, M. M., Lange, E., Marcial-Coba, M. S., Bar-Shalom, Daniel, Nielsen, Dennis Sandris & Mullertz, Anette , 2021, In: LWT. 144, 9 p., 111174.

    Research output: Contribution to journalJournal articlepeer-review

  52. Published

    Drug solubilization during simulated pediatric gastro-intestinal digestion

    Kofoed-Djursner, C., Jamil, A., Selen, A., Mullertz, Anette & Berthelsen, R., 2021, In: European Journal of Pharmaceutical Sciences. 162, 8 p., 105828.

    Research output: Contribution to journalJournal articlepeer-review

  53. Published

    Effects of recombinant human gastric lipase and pancreatin during in vitro pediatric gastro-intestinal digestion

    Heerup, C., Ebbesen, M. F., Geng, X., Madsen, S. F., Berthelsen, R. & Mullertz, Anette , 2021, In: Food & Function. 12, 7, p. 2938-2949 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  54. Published

    Estimating the Oral Absorption from Self-Nanoemulsifying Drug Delivery Systems Using an In Vitro Lipolysis-Permeation Method

    Klitgaard, Mette, Mullertz, Anette & Berthelsen, R., 2021, In: Pharmaceutics. 13, 4, 14 p., 489.

    Research output: Contribution to journalJournal articlepeer-review

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