Hanne Mørck Nielsen

Nanogel delivery systems for cationic peptides: More than a ‘One Size Fits All’ solution

Kłodzińska, S. N., Wang, Qiuyue, Molchanova, N., Mahmoudi, N., Vallooran, J. J., Hansen, Paul Robert, Jenssen, H. & Nielsen, Hanne Mørck, 2024, In: Journal of Colloid and Interface Science. 663, p. 449-457

Research output: Contribution to journal › Journal article › Research › peer-review

Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation

Mortensen, Janni Støvring, Bohr, S. S. R., Krog, Lasse Skjoldborg, Bøtker, Johan Peter, Kapousidou, V., Saaby, Lasse, Hatzakis, Nikos, Nielsen, Hanne Mørck, Nguyen, Duc Ninh & Rønholt, Stine, 2024, In: Scientific Reports. 14, 1, 17 p., 7665.

Research output: Contribution to journal › Journal article › Research › peer-review

Ca²⁺-Responsive Glyco-insulin

Wu, S., Østergaard, M., Fredholt, Freja, Christensen, Niels Johan, Sørensen, K. K., Mishra, N. K., Nielsen, Hanne Mørck & Jensen, Knud Jørgen, 2023, In: Bioconjugate Chemistry. 34, 3, p. 518–528

Research output: Contribution to journal › Journal article › Research › peer-review

Carrier peptide interactions with liposome membranes induce reversible clustering by surface adsorption and shape deformation

Diedrichsen, Ragna Guldsmed, Vetri, V., Prévost, S., Foderà, Vito & Nielsen, Hanne Mørck, 2023, In: Journal of Colloid and Interface Science. 650, Part B, p. 1821-1832

Research output: Contribution to journal › Journal article › Research › peer-review

Corrigendum to "Polysorbate 80 controls Morphology, structure and stability of human insulin Amyloid-Like spherulites" [J. Colloid Interface Sci. 606(Part 2) (2022) 1928-1939]

Zhou, X., Galparsoro, D. F., Madsen, Anders Østergaard, Vetri, V., van de Weert, Marco, Nielsen, Hanne Mørck & Foderà, Vito, 2023, In: Journal of Colloid and Interface Science. 640, p. 917

Research output: Contribution to journal › Journal article › Research › peer-review

Effects of prophylactic antibiotics administration on barrier properties of intestinal mucosa and mucus from preterm born piglets

Mortensen, Janni Støvring, Nguyen, Duc Ninh, Nielsen, Hanne Mørck & Rønholt, Stine, 2023, In: Drug Delivery and Translational Research. 13, p. 1456–1469

Research output: Contribution to journal › Journal article › Research › peer-review

Encapsulation in oleyl-modified hyaluronic acid nanogels substantially improves the clinical potential of the antimicrobial peptides SAAP-148 and Ab-Cath

van Gent, M. E., Klodzinska, S. N., Drijfhout, J. W., Nielsen, Hanne Mørck & Nibbering, P. H., 2023, In: European Journal of Pharmaceutics and Biopharmaceutics. 193, p. 254-261

Research output: Contribution to journal › Journal article › Research › peer-review

Encapsulation into hyaluronic acid-based nanogels improves the selectivity index of the snake cathelicidin Ab-Cath

van Gent, M. E., Kłodzińska, S. N., Severin, M., Ali, M., van Doodewaerd, B. R., Bos, E., Koning, R. I., Drijfhout, J. W., Nielsen, Hanne Mørck & Nibbering, P. H., 2023, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 52, 11 p., 102694.

Research output: Contribution to journal › Journal article › Research › peer-review

Encapsulation of SAAP-148 in Octenyl Succinic Anhydride-Modified Hyaluronic Acid Nanogels for Treatment of Skin Wound Infections

van Gent, M. E., van Baaren, T., Kłodzińska, S. N., Ali, M., Dolezal, N., van Doodewaerd, B. R., Bos, E., de Waal, A. M., Koning, R. I., Drijfhout, J. W., Nielsen, Hanne Mørck & Nibbering, P. H., 2023, In: Pharmaceutics. 15, 2, 20 p., 429.

Research output: Contribution to journal › Journal article › Research › peer-review

Epithelium dynamics differ in time and space when exposed to the permeation enhancers penetramax and EGTA. A head-to-head mechanistic comparison

Panou, D. A., Pedersen, Stine Helene Falsig, Kristensen, Mie & Nielsen, Hanne Mørck, 2023, In: Frontiers in Drug Delivery. 3, 16 p., 1221628.

Research output: Contribution to journal › Journal article › Research › peer-review

Heterogeneous and Surface-Catalyzed Amyloid Aggregation Monitored by Spatially Resolved Fluorescence and Single Molecule Microscopy

Zhou, X., Sinkjær, Anders Wilgaard, Zhang, Min, Pinholt, H. D., Nielsen, Hanne Mørck, Hatzakis, Nikos, van de Weert, Marco & Foderà, Vito, 2023, In: The Journal of Physical Chemistry Letters. 14, 4, p. 912-919

Research output: Contribution to journal › Journal article › Research › peer-review

Mucoadhesive Dendrons Conjugated to Mesoporous Silica Nanoparticles as a Drug Delivery Approach for Orally Administered Biopharmaceuticals

Tollemeto, M., Huang, Z., Christensen, Jørn Bolstad, Nielsen, Hanne Mørck & Rønholt, Stine, 2023, In: ACS Applied Materials and Interfaces. 15, 7, p. 8798–8810

Research output: Contribution to journal › Journal article › Research › peer-review

Mucoadhesive chitosan- and cellulose derivative-based nanofiber-on-foam-on-film system for non-invasive peptide delivery

Stie, Mai Bay, Öblom, H., Hansen, Anders Christian Nørgaard, Jacobsen, Jette, Chronakis, I. S., Rantanen, Jukka, Nielsen, Hanne Mørck & Genina, Natalja, 2023, In: Carbohydrate Polymers. 303, 120429.

Research output: Contribution to journal › Journal article › Research › peer-review

Stereochemistry and Intermolecular Interactions Influence Carrier Peptide-Mediated Insulin Delivery

Diedrichsen, Ragna Guldsmed, Tuelung, P. S., Foderà, Vito & Nielsen, Hanne Mørck, 2023, In: Molecular Pharmaceutics. 20, 2, p. 1202–1212

Research output: Contribution to journal › Journal article › Research › peer-review

Stereoisomer-Dependent Membrane Association and Capacity for Insulin Delivery Facilitated by Penetratin

Birch, D., Sayers, E. J., Christensen, M. V., Jones, A. T., Franzyk, Henrik & Nielsen, Hanne Mørck, 2023, In: Pharmaceutics. 15, 6, 15 p., 1672.

Research output: Contribution to journal › Journal article › Research › peer-review

Barrier properties of ex vivo porcine intestinal mucus are highly independent of isolation and storage conditions

Mortensen, Janni Støvring, Saaby, Lasse, Rønholt, Stine & Nielsen, Hanne Mørck, 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 174, p. 106-110

Research output: Contribution to journal › Journal article › Research › peer-review

Direct observations of drug nanocarrier interactions and mobility within biological interfaces

Bohr, S. S. R., Streck, S., Pinholt, H., Wan, F., Mcdowell, A., Nielsen, Hanne Mørck & Hatzakis, Nikos, 2022, In: Biophysical Journal. 121, 3, p. 72a-73a 2 p., 355-Pos.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Investigating the effect of graphene oxide in chitosan/alginate-based foams on the release and antifungal activity of clotrimazole in vitro

Huang, Jianfei, Jacobsen, Jette, Genina, Natalja, Larsen, Susan Weng, Nielsen, Hanne Mørck, Mullertz, Anette & Mu, Huiling, 2022, In: European Journal of Pharmaceutical Sciences. 174, 9 p., 106204.

Research output: Contribution to journal › Journal article › Research › peer-review

Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin

Stie, Mai Bay, Gätke, J. R., Chronakis, I. S., Jacobsen, Jette & Nielsen, Hanne Mørck, 2022, In: International Journal of Molecular Sciences. 23, 3, 9 p., 1458.

Research output: Contribution to journal › Journal article › Research › peer-review

Physical and barrier changes in gastrointestinal mucus induced by the permeation enhancer sodium 8-[(2-hydroxybenzoyl)amino]octanoate (SNAC)

Mortensen, Janni Støvring, Bohr, S. S. R., Rønholt, Stine, Hatzakis, Nikos, Saaby, Lasse & Nielsen, Hanne Mørck, 2022, In: Journal of Controlled Release. 352, p. 163-178 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Polysorbate 80 controls Morphology, structure and stability of human insulin Amyloid-Like spherulites

Zhou, X., Fennema Galparsoro, D., Madsen, Anders Østergaard, Vetri, V., van de Weert, Marco, Nielsen, Hanne Mørck & Foderà, Vito, 2022, In: Journal of Colloid and Interface Science. 606, Pt 2, p. 1928-1939

Research output: Contribution to journal › Journal article › Research › peer-review

Topical niclosamide (ATx201) reduces Staphylococcus aureus colonization and increases Shannon diversity of the skin microbiome in atopic dermatitis patients in a randomized, double-blind, placebo-controlled Phase 2 trial

Weiss, A., Delavenne, E., Matias, C., Lagler, H., Simon, D., Li, P., Hansen, J. U., Dos Santos, T. P., Jana, B., Priemel, P., Bangert, C., Bauer, M., Eberl, S., Nussbaumer-Pröll, A., Anne Österreicher, Z., Matzneller, P., Quint, T., Weber, M., Nielsen, H. M., Rades, T. & 17 others, Johansen, Helle Krogh, Westh, Henrik T., Kim, W., Mylonakis, E., Friis, C., Guardabassi, Luca, Pace, J., Lundberg, C. V., M'Zali, F., Butty, P., Sørensen, N., Nielsen, H. B., Toft-Kehler, R., Guttman-Yassky, E., Stingl, G., Zeitlinger, M. & Sommer, M., 2022, In: Clinical and Translational Medicine. 12, 5, e790.

Research output: Contribution to journal › Journal article › Research › peer-review

Additive manufacturing of polymeric scaffolds for biomimetic cell membrane engineering

Rovira, D. S., Nielsen, Hanne Mørck, Taboryski, R. & Bunea, A., 2021, In: Materials and Design. 201, 11 p., 109486.

Research output: Contribution to journal › Journal article › Research › peer-review

Controlling the fractal dimension in self-assembly of terpyridine modified insulin by Fe²⁺ and Eu³+ to direct in vivo effects

Mishra, N. K., Østergaard, M., Midtgaard, S. R., Strindberg, S. S., Winkler, S., Wu, S., Sørensen, Thomas Just, Hassenkam, Tue, Poulsen, Jens-Christian Navarro, Lo Leggio, Leila, Nielsen, Hanne Mørck, Arleth, Lise, Christensen, Niels Johan, Thulstrup, Peter Waaben & Jensen, Knud Jørgen, 2021, In: Nanoscale. 13, 18, p. 8467–8473 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Design of a self-unfolding delivery concept for oral administration of macromolecules

Jørgensen, J. R., Thamdrup, L. H. E., Kamguyan, K., Nielsen, L. H., Nielsen, Hanne Mørck, Boisen, A., Rades, Thomas & Mullertz, Anette , 2021, In: Journal of Controlled Release. 329, p. 948-954

Research output: Contribution to journal › Journal article › Research › peer-review

Interactions of Cell-Penetrating Peptide-Modified Nanoparticles with Cells Evaluated Using Single Particle Tracking

Streck, S., Bohr, S. S., Birch, D., Rades, Thomas, Hatzakis, Nikos, McDowell, A. & Nielsen, Hanne Mørck, 2021, In: ACS Applied Bio Materials. 4, 4, p. 3155-3165 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Nanoparticle-mediated pulmonary drug delivery: state of the art towards efficient treatment of recalcitrant respiratory tract bacterial infections

Huang, Z., Klodzinska, S. N., Wan, F. & Nielsen, Hanne Mørck, 2021, In: Drug Delivery and Translational Research. 11, p. 1634–1654

Research output: Contribution to journal › Journal article › Research › peer-review

Peptide-Membrane Interactions Monitored by Fluorescence Lifetime Imaging: A Study Case of Transportan 10

Anselmo, S., Sancataldo, G., Nielsen, Hanne Mørck, Foderà, Vito & Vetri, V., 2021, In: Langmuir. 37, 44, p. 13148-13159

Research output: Contribution to journal › Journal article › Research › peer-review

Revealing the importance of carrier-cargo association in delivery of insulin and lipidated insulin

Diedrichsen, Ragna Guldsmed, Rønholt, Stine, Werner, U., Besenius, M., Leberer, E., Kristensen, Mie & Nielsen, Hanne Mørck, 2021, In: Journal of Controlled Release. 338, p. 8-21

Research output: Contribution to journal › Journal article › Research › peer-review

Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa

Stie, Mai Bay, Gätke, J. R., Wan, F., Chronakis, I. S., Jacobsen, Jette & Nielsen, Hanne Mørck, 15 Aug 2020, In: Carbohydrate Polymers. 242, 10 p., 116428.

Research output: Contribution to journal › Journal article › Research › peer-review

EJP18 peptide derived from the juxtamembrane domain of epidermal growth factor receptor represents a novel membrane-active cell-penetrating peptide

Eissa, N. G., Sayers, E. J., Birch, D., Patel, S. G., Tsai, Y. H., Nielsen, Hanne Mørck & Jones, A. T., 8 Jan 2020, In: Biochemical Journal. 477, 1, p. 45-60 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

In Vitro, Ex Vivo and In Vivo Evaluation of Microcontainers for Oral Delivery of Insulin

Jørgensen, J. R., Yu, F., Ramakrishnan, V., Nielsen, L. H., Nielsen, Hanne Mørck, Boisen, A., Rades, Thomas & Mullertz, Anette , 7 Jan 2020, In: Pharmaceutics. 12, 1, 14 p., 48.

Research output: Contribution to journal › Journal article › Research › peer-review

A free-floating mucin layer to investigate the effect of the local microenvironment in lungs on mucin-nanoparticle interactions

Wan, F., Herzberg, M., Huang, Z., Hassenkam, Tue & Nielsen, Hanne Mørck, 2020, In: Acta Biomaterialia. 104, 1, p. 115-123

Research output: Contribution to journal › Journal article › Research › peer-review

Electrospun α-lactalbumin nanofibers for site-specific and fast-onset delivery of nicotine in the oral cavity: an in vitro, ex vivo and tissue spatial distribution study

Kalouta, Kleopatra, Stie, Mai Bay, Janfelt, Christian, Chronakis, I. S., Jacobsen, Jette, Nielsen, Hanne Mørck & Foderà, Vito, 2020, In: Molecular Pharmaceutics. 17, 11, p. 4189-4200

Research output: Contribution to journal › Journal article › Research › peer-review

Graphene oxide as a functional excipient in buccal films for delivery of clotrimazole: effect of molecular interactions on drug release and antifungal activity in vitro

Huang, Jianfei, Jacobsen, Jette, Larsen, Susan Weng, Genina, Natalja, van de Weert, Marco, Mullertz, Anette , Nielsen, Hanne Mørck & Mu, Huiling, 2020, In: International Journal of Pharmaceutics. 589, p. 1-9 119811.

Research output: Contribution to journal › Journal article › Research › peer-review

Increased Carrier Peptide Stability through pH Adjustment Improves Insulin and PTH(1-34) Delivery In Vitro and In Vivo Rather than by Enforced Carrier Peptide-Cargo Complexation

Kristensen, Mie, Diedrichsen, Ragna Guldsmed, Vetri, V., Foderà, Vito & Nielsen, Hanne Mørck, 2020, In: Pharmaceutics. 12, 10, 18 p., 993.

Research output: Contribution to journal › Journal article › Research › peer-review

Membrane interactions in drug delivery: Model cell membranes and orthogonal techniques

Bunea, A., Rønholt, Stine, Taboryski, R. & Nielsen, Hanne Mørck, 2020, In: Advances in Colloid and Interface Science. 281, 15 p., 102177.

Research output: Contribution to journal › Review › Research › peer-review

Monosized Polymeric Microspheres Designed for Passive Lung Targeting: Biodistribution and Pharmacokinetics after Intravenous Administration

Agnoletti, M., Rodríguez-Rodríguez, C., Klodzinska, S. N., Esposito, T., Saatchi, K., Nielsen, Hanne Mørck & Häfeli, U. O., 2020, In: ACS Nano. 14, p. 6693-6706

Research output: Contribution to journal › Journal article › Research › peer-review

Shuffled lipidation pattern and degree of lipidation determines the membrane interaction behavior of a linear cationic membrane-active peptide

Hedegaard, S. F., Bruhn, D. S., Khandelia, H., Cardenas, M. & Nielsen, Hanne Mørck, 2020, In: Journal of Colloid and Interface Science. 578, p. 584-597 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Synthesis of carbon quantum dot-poly lactic-co-glycolic acid hybrid nanoparticles for chemo-photothermal therapy against bacterial biofilms

Huang, Z., Zhou, T., Yuan, Y., Klodziska, S. N., Zheng, T., Sternberg, C., Nielsen, Hanne Mørck, Sun, Y. & Wan, F., 2020, In: Journal of Colloid and Interface Science. 577, p. 66-74 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Ultrasmall TPGS-PLGA Hybrid Nanoparticles for Site-Specific Delivery of Antibiotics into Pseudomonas aeruginosa Biofilms in Lungs

Wan, F., Bohr, S. S. R., Kłodzińska, S. N., Jumaa, H., Huang, Z., Nylander, T., Thygesen, Mikkel Boas, Sørensen, K. K., Jensen, Knud Jørgen, Sternberg, C., Hatzakis, Nikos & Nielsen, Hanne Mørck, 2020, In: ACS Applied Materials and Interfaces. 12, p. 380-389

Research output: Contribution to journal › Journal article › Research › peer-review

Waterborne Electrospinning of α-Lactalbumin Generates Tunable and Biocompatible Nanofibers for Drug Delivery

Stie, Mai Bay, Corezzi, M., Juncos Bombin, A. D., Ajalloueian, F., Attrill, E., Pagliara, S., Jacobsen, Jette, Chronakis, I. S., Nielsen, Hanne Mørck & Foderà, Vito, 2020, In: ACS Applied Nano Materials. 3, 2, p. 1910–1921

Research output: Contribution to journal › Journal article › Research › peer-review

Comparison of bulk and microfluidics methods for the formulation of poly-lactic-co-glycolic acid (PLGA) nanoparticles modified with cell-penetrating peptides of different architectures

Streck, S., Neumann, H., Nielsen, Hanne Mørck, Rades, Thomas & McDowell, A., Dec 2019, In: International Journal of Pharmaceutics: X. 1, 9 p., 100030.

Research output: Contribution to journal › Journal article › Research › peer-review

The distribution of cell-penetrating peptides on polymeric nanoparticles prepared using microfluidics and elucidated with small angle X-ray scattering

Streck, S., Clulow, A. J., Nielsen, Hanne Mørck, Rades, Thomas, Boyd, B. J. & McDowell, A., 1 Nov 2019, In: Journal of Colloid and Interface Science. 555, p. 438-448 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Utilizing nanoparticles for improving anti-biofilm effects of azithromycin: A head-to-head comparison of modified hyaluronic acid nanogels and coated poly (lactic-co-glycolic acid) nanoparticles

Kłodzińska, S. N., Wan, F., Jumaa, H., Sternberg, C., Rades, Thomas & Nielsen, Hanne Mørck, 1 Nov 2019, In: Journal of Colloid and Interface Science. 555, p. 595-606 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging

Clitherow, K. H., Murdoch, C., Spain, S. G., Handler, A. M., Colley, H. E., Stie, Mai Bay, Nielsen, Hanne Mørck, Janfelt, Christian, Hatton, P. V. & Jacobsen, Jette, Sep 2019, In: Molecular Pharmaceutics. 16, 9, p. 3948-3956

Research output: Contribution to journal › Journal article › Research › peer-review

Repurposing Azithromycin and Rifampicin Against Gram-Negative Pathogens by Combination With Peptidomimetics

Baker, K. R., Jana, B., Hansen, A. M., Nielsen, Hanne Mørck, Franzyk, Henrik & Guardabassi, Luca, 2 Jul 2019, In: Frontiers in Cellular and Infection Microbiology. 9

Research output: Contribution to journal › Journal article › Research › peer-review

Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers

Stie, Mai Bay, Jones, M., Sørensen, H. O., Jacobsen, Jette, Chronakis, I. S. & Nielsen, Hanne Mørck, 1 Jul 2019, In: Carbohydrate Polymers. 215, p. 253-262

Research output: Contribution to journal › Journal article › Research › peer-review

Interaction of Laponite with Membrane Components-Consequences for Bacterial Aggregation and Infection Confinement

Malekkhaiat Häffner, S., Nyström, L., Browning, K. L., Nielsen, Hanne Mørck, Strömstedt, A. A., van der Plas, Mariena J.A., Schmidtchen, A. & Malmsten, Martin, 1 May 2019, In: A C S Applied Materials and Interfaces. 11, 17, p. 15389-15400 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Qualitative and quantitative analysis of the biophysical interaction of inhaled nanoparticles with pulmonary surfactant by using quartz crystal microbalance with dissipation monitoring

Wan, F., Nylander, T., Foged, Camilla, Yang, Mingshi, Baldursdottir, S. G. & Nielsen, Hanne Mørck, 1 Mar 2019, In: Journal of Colloid and Interface Science. 545, p. 162-171 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exploring the mucoadhesive behavior of sucrose acetate isobutyrate: a novel excipient for oral delivery of biopharmaceuticals

Rønholt, Stine, Fliervoet, L. A. L., Fano, M., Schmitt, M., Antopolski, M., Urtti, A. & Nielsen, Hanne Mørck, 1 Jan 2019, In: Drug Delivery. 26, 1, p. 532-541

Research output: Contribution to journal › Journal article › Research › peer-review

¹⁹F-substituted amino acids as an alternative to fluorophore labels: monitoring of degradation and cellular uptake of analogues of penetratin by ¹⁹F NMR

Christensen, M. V., Kongstad, Kenneth Thermann, Sondergaard, T. E., Stærk, Dan, Nielsen, Hanne Mørck, Franzyk, Henrik & Wimmer, R., 2019, In: Journal of Biomolecular N M R. 73, p. 167-182

Research output: Contribution to journal › Journal article › Research › peer-review

Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients

Molchanova, N., Wang, H., Hansen, Paul Robert, Høiby, Niels, Nielsen, Hanne Mørck & Franzyk, Henrik, 2019, In: Frontiers in Microbiology. 10, 9 p., 275.

Research output: Contribution to journal › Journal article › Research › peer-review

Hyaluronic acid-based nanogels improve in vivo compatibility of the anti-biofilm peptide DJK-5

Kłodzińska, S. N., Pletzer, D., Rahanjam, N., Rades, Thomas, Hancock, R. E. W. & Nielsen, Hanne Mørck, 2019, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 20, 102022.

Research output: Contribution to journal › Journal article › Research › peer-review

Impact of capacity-limited binding on recombinant factor VIII and von Willebrand factor pharmacokinetics in hemophilia A rats

Vargas Christensen, I., Loftager, M., Rode, F., Nielsen, Hanne Mørck, Kreilgaard, M. & Larsen, M. S., 2019, In: Journal of Thrombosis and Haemostasis. 17, 6, p. 964-974 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Lipidoid-Polymer Hybrid Nanoparticles Loaded with TNF siRNA Suppress Inflammation after Intra-articular Administration in a Murine Experimental Arthritis Model

Jansen, M. A. A., Klausen, L. H., Thanki, K., Lyngsø, J., Skov Pedersen, J., Franzyk, Henrik, Nielsen, Hanne Mørck, van Eden, W., Dong, M., Broere, F., Foged, Camilla & Zeng, X., 2019, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 142, p. 38-48

Research output: Contribution to journal › Journal article › Research › peer-review

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

Thanki, K., van Eetvelde, D., Geyer, A., Fraire, J., Hendrix, R., Van Eygen, H., Putteman, E., Sami, H., de Souza Carvalho-Wodarz, C., Franzyk, Henrik, Nielsen, Hanne Mørck, Braeckmans, K., Lehr, C., Ogris, M. & Foged, Camilla, 2019, In: Journal of controlled release : official journal of the Controlled Release Society. 310, p. 82-93

Research output: Contribution to journal › Journal article › Research › peer-review

Microcontainers for oral insulin delivery - in vitro studies of permeation enhancement

Rune Jørgensen, J., Leth Jepsen, M., Hagner Nielsen, L., Dufva, M., Nielsen, Hanne Mørck, Rades, Thomas, Boisen, A. & Mullertz, Anette , 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 143, p. 98-105

Research output: Contribution to journal › Journal article › Research › peer-review

Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators

Baker, K. R., Jana, B., Hansen, A. M., Vissing, K. J., Nielsen, Hanne Mørck, Franzyk, Henrik & Guardabassi, Luca, 2019, In: International Journal of Antimicrobial Agents. 53, p. 868-872 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Poly(ethylene carbonate)-containing polylactic acid microparticles with rifampicin improve drug delivery to macrophages

Priemel, P. A., Wang, Y., Bohr, A., Water, J. J., Yang, Mingshi & Nielsen, Hanne Mørck, Aug 2018, In: Journal of Pharmacy and Pharmacology. 70, 8, p. 1009-1021

Research output: Contribution to journal › Journal article › Research › peer-review

Biopolymer nanogels improve antibacterial activity and safety profile of a novel lysine-based α-peptide/β-peptoid peptidomimetic

Kłodzińska, S. N., Molchanova, N., Franzyk, Henrik, Hansen, Paul Robert, Damborg, Peter Panduro & Nielsen, Hanne Mørck, Jul 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 128, p. 1-9 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design

de Groot, A. M., Thanki, K., Gangloff, M., Falkenberg, E., Zeng, X., van Bijnen, D. C. J., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck, Broere, F., Gay, N. J., Foged, Camilla & Sijts, A. J. A. M., 1 Jun 2018, In: Molecular Therapy - Nucleic Acids. 11, p. 159-169 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Evaluation of drug permeation under fed state conditions using mucus-covered Caco-2 cell epithelium

Birch, D., Diedrichsen, Ragna Guldsmed, Christophersen, P. C., Mu, Huiling & Nielsen, Hanne Mørck, Jun 2018, In: European Journal of Pharmaceutical Sciences. 118, p. 144-153

Research output: Contribution to journal › Journal article › Research › peer-review

Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity

Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 24 May 2018, In: Biochemical Journal. 475, 10, p. 1773-1788 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

In Vitro ADME Properties of Two Novel Antimicrobial Peptoid-Based Compounds as Potential Agents against Canine Pyoderma

Greco, I., Hummel, B. D., Vasir, J., Watts, J. L., Koch, J., Hansen, J. E., Nielsen, Hanne Mørck, Damborg, Peter Panduro & Hansen, Paul Robert, 10 Mar 2018, In: Molecules. 23, 3, 15 p., 630.

Research output: Contribution to journal › Journal article › Research › peer-review

Lipid shell-enveloped polymeric nanoparticles with high integrity of lipid shells improve mucus penetration and interaction with cystic fibrosis-related bacterial biofilms

Wan, F., Nylander, T., Klodzinska, S. N., Foged, Camilla, Yang, Mingshi, Baldursdottir, S. G. & Nielsen, Hanne Mørck, 23 Feb 2018, In: A C S Applied Materials and Interfaces. 10, 13, p. 10678–10687

Research output: Contribution to journal › Journal article › Research › peer-review

Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing

Liu, X., Nielsen, L. H., Klodzinska, S. N., Nielsen, Hanne Mørck, Qu, H., Christensen, L. P., Rantanen, Jukka & Yang, Mingshi, Feb 2018, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 123, p. 42-49

Research output: Contribution to journal › Journal article › Research › peer-review

Combining diagnostic methods for antimicrobial susceptibility testing – A comparative approach

Klodzinska, S. N., Priemel, P. A., Rades, Thomas & Nielsen, Hanne Mørck, Jan 2018, In: Journal of Microbiological Methods. 144, p. 177-185

Research output: Contribution to journal › Journal article › Research › peer-review

The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles

García-Díaz, M., Birch, D., Wan, F. & Nielsen, Hanne Mørck, Jan 2018, In: Advanced Drug Delivery Reviews. 124, p. 107-124

Research output: Contribution to journal › Journal article › Research › peer-review

Cellular effects and delivery propensity of penetratin is influenced by conjugation to parathyroid hormone fragment 1-34 in synergy with pH

Kristensen, Mie, Nielsen, L. H., Zor, K., Boisen, A., Christensen, M. V., Berthelsen, J. & Nielsen, Hanne Mørck, 2018, In: Bioconjugate Chemistry. 29, 2, p. 371-381

Research output: Contribution to journal › Journal article › Research › peer-review

Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing

Nielsen, Hanne Mørck, 2018, In: European Journal of Pharmaceutics and Biopharmaceutics.

Research output: Contribution to journal › Journal article › Research › peer-review

Fluorophore labeling of a cell-penetrating peptide significantly alters the mode and degree of biomembrane interaction

Hedegaard, S. F., Derbas, M. S., Lind, T. K., Kasimova, M. R., Christensen, M. V., Michaelsen, M. H., Campbell, R. A., Jørgensen, Lene, Franzyk, Henrik, Cárdenas, M. & Nielsen, Hanne Mørck, 2018, In: Scientific Reports. 8, 1, 14 p., 6327.

Research output: Contribution to journal › Journal article › Research › peer-review

The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles

Nielsen, Hanne Mørck, 2018, In: Advanced Drug Delivery Reviews.

Research output: Contribution to journal › Journal article › Research › peer-review

Animal models for evaluation of oral delivery of biopharmaceuticals

Rønholt, Stine, Nielsen, L. H. & Nielsen, Hanne Mørck, Dec 2017, In: Journal of Controlled Release. 268, p. 57-71 15 p.

Research output: Contribution to journal › Review › Research › peer-review

The impact of particle preparation methods and polymorphic stability of lipid excipients on protein distribution in microparticles

Liu, J., Christophersen, P. C., Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, Dec 2017, In: Drug Development and Industrial Pharmacy. 43, 12, p. 2032-2042 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Engineering of small interfering RNA-loaded lipidoid-poly(DL-lactic-co-glycolic acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach

Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Van Driessche, E., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, Nov 2017, In: European Journal of Pharmaceutics and Biopharmaceutics. 120, p. 22-33 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Innovative Methods and Applications in Mucoadhesion Research

Mackie, A. R., Goycoolea, F. M., Menchicchi, B., Caramella, C. M., Saporito, F., Lee, S., Stephansen, K., Chronakis, I. S., Hiorth, M., Adamczak, M., Waldner, M., Nielsen, Hanne Mørck & Marcelloni, L., Aug 2017, In: Macromolecular Bioscience. 17, 8, 32 p., 1600534.

Research output: Contribution to journal › Review › Research › peer-review

Assessment of mucoadhesion using small deformation rheology revisited

Rønholt, Stine, Vissing, K. J. & Nielsen, Hanne Mørck, Apr 2017, In: Nordic Rheology Society Annual Transactions. 25, p. 63 7 p.

Research output: Contribution to journal › Conference article › Research › peer-review

Fluorophore labeling of a cell-penetrating peptide induces differential effects on its cellular distribution and affects cell viability

Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 2017, In: B B A - Biomembranes. 1859, 12, p. 2483-2494

Research output: Contribution to journal › Journal article › Research › peer-review

Lysine-Based α-peptide/β-peptoid peptidomimetics: Influence of hydrophobicity, fluorination and distribution of cationic charge on antimicrobial activity and cytotoxicity

Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro, Nielsen, Hanne Mørck & Franzyk, Henrik, 2017, In: ChemMedChem. 12, p. 312-318 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Inhalable Antimicrobials for Treatment of Bacterial Biofilm-Associated Sinusitis in Cystic Fibrosis Patients: Challenges and Drug Delivery Approaches

Klodzinska, S. N., Priemel, P. A., Rades, Thomas & Nielsen, Hanne Mørck, 9 Oct 2016, In: International Journal of Molecular Sciences . 17, 10, 19 p., 1688.

Research output: Contribution to journal › Journal article › Research › peer-review

Impact of lipid-based drug delivery systems on the transport and uptake of insulin across Caco-2 Cell monolayers

Li, P., Nielsen, Hanne Mørck & Mullertz, Anette , Sep 2016, In: Journal of Pharmaceutical Sciences. 105, 9, p. 2743-51 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System.

Jing, X., Foged, Camilla, Martin-Bertelsen, Birte, Yaghmur, Anan, Knapp, K. M., Malmsten, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 6 Jun 2016, In: Molecular Pharmaceutics. 13, 6, p. 1739-1749 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Interactions between Surfactants in Solution and Electrospun Protein Fibers: Effects on Release Behavior and Fiber Properties

Stephansen, K., García-Díaz, M., Jessen, F., Chronakis, I. S. & Nielsen, Hanne Mørck, 7 Mar 2016, In: Molecular Pharmaceutics. 13, 3, p. 748-55 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Cell-Penetrating Peptides as Carriers for Oral Delivery of Biopharmaceuticals

Kristensen, Mie & Nielsen, Hanne Mørck, Feb 2016, In: Basic & Clinical Pharmacology & Toxicology Online. 118, 2, p. 99-106 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Applications and Challenges for Use of Cell-Penetrating Peptides as Delivery Vectors for Peptide and Protein Cargos

Kristensen, Mie, Birch, D. & Nielsen, Hanne Mørck, 30 Jan 2016, In: International Journal of Molecular Sciences . 17, 2, p. 1-17 17 p., 185.

Research output: Contribution to journal › Review › Research › peer-review

Cell-penetrating peptides as tools to enhance non-injectable delivery of biopharmaceuticals

Kristensen, Mie & Nielsen, Hanne Mørck, 2016, In: Tissue Barriers. 4, 2, 15 p., e1178369.

Research output: Contribution to journal › Review › Research › peer-review

Large-scale biophysical evaluation of protein PEGylation effects: in vitro properties of 61 protein entities

Vernet, E., Popa, G., Pozdnyakova, I., Rasmussen, J. E., Grohganz, Holger, Giehm, L., Jensen, M. H., Wang, H., Plesner, B., Nielsen, Hanne Mørck, Jensen, Knud Jørgen, Berthelsen, J., Sundström, M. & van de Weert, Marco, 2016, In: Molecular Pharmaceutics. 13, 5, p. 1587-1598 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Quantification of pharmaceutical peptides in human plasma by LC-ICP-MS sulfur detection

Møller, L. H., Macherius, A., Hansen, Thomas Hesselhøj, Nielsen, Hanne Mørck, Cornett, Claus, Østergaard, Jesper, Stürup, Stefan & Gammelgaard, Bente, 2016, In: Journal of Analytical Atomic Spectrometry. 31, p. 1877-1884 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Soft hydrogels interpenetrating silicone – a polymer network for drug releasing medical devices

Steffensen, S. L., Merete H., V., Møller, E. H., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2016, In: Journal of Biomedical Materials Research. Part B: Applied Biomaterials. 104, 2, p. 402-410 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Antimicrobial activity of GN peptides and their mode of action

Godballe, T., Mojsoska, B., Nielsen, Hanne Mørck & Jenssen, H., 13 Dec 2015, In: Biopolymers. 106, 2, p. 172–183 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Bioactive protein-based nanofibers interact with intestinal biological components resulting in transepithelial permeation of a therapeutic protein

Stephansen, K., García-Díaz, M., Jessen, F., Chronakis, I. S. & Nielsen, Hanne Mørck, 10 Nov 2015, In: International Journal of Pharmaceutics. 495, 1, p. 58-66 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Steric and interactive barrier properties of intestinal mucus elucidated by particle diffusion and peptide permeation

Bøgh, M., García-Díaz, M., Mullertz, Anette & Nielsen, Hanne Mørck, Sep 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 94, Part A, p. 136–143 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Hyaluronic Acid-Based Nanogels Produced by Microfluidics-Facilitated Self-Assembly Improves the Safety Profile of the Cationic Host Defense Peptide Novicidin

Water, J. J., Kim, Y., Maltesen, M. J., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, Aug 2015, In: Pharmaceutical Research. 32, 8, p. 2727-35 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Conjugation of a cell-penetrating peptide to parathyroid hormone affects its structure, potency, and transepithelial permeation

Kristensen, Mie, de Groot, A. M., Berthelsen, J., Franzyk, Henrik, Sijts, A. & Nielsen, Hanne Mørck, 18 Mar 2015, In: Bioconjugate Chemistry. 26, p. 477-488 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Mechanistic profiling of the siRNA delivery dynamics of lipid-polymer hybrid nanoparticles

Colombo, S., Cun, D., Remaut, K., Bunker, M., Zhang, J., Martin-Bertelsen, Birte, Yaghmur, Anan, Braeckmans, K., Nielsen, Hanne Mørck & Foged, Camilla, 10 Mar 2015, In: Journal of Controlled Release. 201, p. 22-31 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Mucus as a Barrier to Drug Delivery: Understanding and Mimicking the Barrier Properties

Bøgh, M. & Nielsen, Hanne Mørck, Mar 2015, In: Basic & Clinical Pharmacology & Toxicology. 116, 3, p. 179-186 8 p.

Research output: Contribution to journal › Review › Research › peer-review

Nanoparticle-mediated delivery of the antimicrobial peptide plectasin against Staphylococcus aureus in infected epithelial cells

Water, J. J., Smart, S., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, 18 Feb 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 92, p. 65-73 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Selenium as an alternative peptide label - comparison to fluorophore-labelled penetratin

Hyrup Møller, L., Bahnsen, J. S., Nielsen, Hanne Mørck, Østergaard, Jesper, Stürup, Stefan & Gammelgaard, Bente, 25 Jan 2015, In: European Journal of Pharmaceutical Sciences. 67, p. 76-84 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

End Group Modification: Efficient Tool for Improving Activity of Antimicrobial Peptide Analogues towards Gram-Positive Bacteria

Jahnsen, R. O., Sandberg-Schaal, A., Frimodt-Møller, N., Nielsen, Hanne Mørck & Franzyk, Henrik, 23 Jan 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 95, Part A, p. 40–46 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Three-Dimensional Printing of Drug-Eluting Implants: Preparation of an Antimicrobial Polylactide Feedstock Material

Water, J. J., Bohr, A., Bøtker, Johan Peter, Aho, J., Sandler, N., Nielsen, Hanne Mørck & Rantanen, Jukka, 15 Jan 2015, In: Journal of Pharmaceutical Sciences. p. 1099–1107 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Investigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-Stokes Raman scattering microscopy

Christophersen, P. C., Birch, D., Saarinen, J., Isomäki, A., Nielsen, Hanne Mørck, Yang, Mingshi, Strachan, C. J. & Mu, Huiling, 10 Jan 2015, In: Journal of Controlled Release. 197, p. 111-120 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections

Bahnsen, J. S., Franzyk, Henrik, Sayers, E. J., Jones, A. T. & Nielsen, Hanne Mørck, 2015, In: Pharmaceutical Research. 32, 5, p. 1546-56 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Cell-penetrating peptides as carriers for transepithelial drug delivery in vitro

Rønholt, Stine, Kristensen, Mie & Nielsen, Hanne Mørck, 2015, In: Methods in Molecular Biology. 1324, p. 261-277 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Characterization of particulate drug delivery systems for oral delivery of Peptide and protein drugs

Christophersen, P. C., Fano, M., Saaby, Lasse, Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, 2015, In: Current Pharmaceutical Design. 21, 19, p. 2611-28 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Improved insulin loading in poly (lactic-co-glycolic) acid (PLGA) nanoparticles upon self-assembly with lipids

Garcia Diaz, M., Foged, Camilla & Nielsen, Hanne Mørck, 2015, In: International Journal of Pharmaceutics. 482, p. 84-91 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Investigation of skin permeation, ex vivo inhibition of venom-induced tissue destruction, and wound healing of African plants used against snakebites

Schmidt, M. M., Stærk, Dan, Nielsen, Hanne Mørck, Brandner, J. M., Diallo, D., Kusamba Zacharie, C., Van Staden, J. & Jäger, A., 2015, In: Journal of Ethnopharmacology. 165, p. 1-8

Research output: Contribution to journal › Journal article › Research › peer-review

Penetratin-Mediated Transepithelial Insulin Permeation: Importance of Cationic Residues and pH for Complexation and Permeation

Kristensen, Mie, Franzyk, Henrik, Klausen, M. T., Iversen, A., Bahnsen, J. S., Skyggebjerg, R. B., Foderà, Vito & Nielsen, Hanne Mørck, 2015, In: A A P S Journal. 17, 5, p. 1200-1209 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: Enhanced gene silencing and reduced adversed effects in vitro

Zeng, X., de Groot, A. M., Sijts, A., Blenke, E. O., Colombo, S., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck & Foged, Camilla, 2015, In: Nanoscale. 7, 46, p. 19687-19698 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Sustained prevention of biofilm formation on a novel silicone matrix suitable for medical devices

Steffensen, S. L., Merete H., V., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 94, p. 305-311

Research output: Contribution to journal › Journal article › Research › peer-review

Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading

Li, P., Tan, A., Prestidge, C. A., Nielsen, Hanne Mørck & Mullertz, Anette , 30 Dec 2014, In: International Journal of Pharmaceutics. 477, 1-2, p. 390-8 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The surface charge of liposomal adjuvants is decisive for their interactions with the Calu-3 and A549 airway epithelial cell culture models

Ingvarsson, P. T., Rasmussen, I. S., Viaene, M., Irlik, P. J., Nielsen, Hanne Mørck & Foged, Camilla, Aug 2014, In: European Journal of Pharmaceutics and Biopharmaceutics. 87, 3, p. 480-8 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin

Christophersen, P. C., Vaghela, D., Mullertz, Anette , Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, Jul 2014, In: A A P S Journal. 16, 4, p. 875-83 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Tailoring Cytotoxicity of Antimicrobial Peptidomimetics with High Activity against Multidrug-Resistant Escherichia coli

Jahnsen, R. D., Sandberg-Schaal, A., Vissing, K. J., Nielsen, Hanne Mørck, Frimodt-Møller, N. & Franzyk, Henrik, 20 Mar 2014, In: Journal of Medicinal Chemistry. 57, 7, p. 2864-2873

Research output: Contribution to journal › Journal article › Research › peer-review

Solid Lipid Particles for Oral Delivery of Peptide and Protein Drugs II - The Digestion of Trilaurin Protects Desmopressin from Proteolytic Degradation

Christophersen, P. C., Zhang, L., Mullertz, Anette , Nielsen, Hanne Mørck, Yang, Mingshi & Mu, Huiling, 13 Mar 2014, In: Pharmaceutical Research. 31, 9, p. 2420-28 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption

Bøgh, M., Baldursdóttir, S. G., Mullertz, Anette & Nielsen, Hanne Mørck, 8 Jan 2014, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 87, p. 227-235 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Buccal delivery of metformin: TR146 cell culture model evaluating the use of bioadhesive chitosan discs for drug permeability enhancement

Sander, C., Nielsen, Hanne Mørck & Jacobsen, Jette, 31 Dec 2013, In: International Journal of Pharmaceutics. 458, 2, p. 254-61 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Characterization of spray dried bioadhesive metformin microparticles for oromucosal administration

Sander, C., Madsen, K. D., Hyrup, B., Nielsen, Hanne Mørck, Rantanen, Jukka & Jacobsen, Jette, Nov 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 85, 3 Pt A, p. 682-8 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Design and characterization of core-shell mPEG-PLGA composite microparticles for development of cell-scaffold constructs

Wen, Y., Gallego, M. R., Nielsen, L. F., Jørgensen, Lene, Møller, E. H. & Nielsen, Hanne Mørck, Sep 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 85, 1, p. 87-98 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Solid lipid particles for oral delivery of peptide and protein drugs I - Elucidating the release mechanism of lysozyme during lipolysis

Christophersen, P. C. B., Zhang, L., Yang, Mingshi, Nielsen, Hanne Mørck, Mullertz, Anette & Mu, Huiling, 2 Aug 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 85, 3, part A, p. 473-480

Research output: Contribution to journal › Journal article › Research › peer-review

Preparation and characterization of insulin-surfactant complexes for loading into lipid-based drug delivery systems

Li, P., Nielsen, Hanne Mørck, Fano, M. & Mullertz, Anette , Aug 2013, In: Journal of Pharmaceutical Sciences. 102, 8, p. 2689-98 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Engineering of an Inhalable DDA/TDB Liposomal Adjuvant: A Quality-by-Design Approach Towards Optimization of the Spray Drying Process

Ingvarsson, P. T., Yang, Mingshi, Mulvad, H., Nielsen, Hanne Mørck, Rantanen, Jukka & Foged, Camilla, 22 Jun 2013, In: Pharmaceutical Research. 30, 11, p. 2772-2784

Research output: Contribution to journal › Journal article › Research › peer-review

Designing CAF-adjuvanted dry powder vaccines: spray drying preserves the adjuvant activity of CAF01

Ingvarsson, P. T., Schmidt, S. T., Christensen, D., Larsen, N. B., Hinrichs, W. L. J., Andersen, P., Rantanen, Jukka, Nielsen, Hanne Mørck, Yang, Mingshi & Foged, Camilla, 8 Feb 2013, In: Journal of Controlled Release. 167, 3, p. 256-264

Research output: Contribution to journal › Journal article › Research › peer-review

Evaluation of carrier-mediated siRNA delivery: lessons for the design of a stem-loop qPCR-based approach for quantification of intracellular full-length siRNA

Colombo, S., Nielsen, Hanne Mørck & Foged, Camilla, 11 Jan 2013, In: Journal of Controlled Release. 166, 3, p. 220-226 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Models to predict intestinal absorption of therapeutic peptides and proteins

Antunes, F., Andrade, F., Ferreira, D., Nielsen, Hanne Mørck & Sarmento, B., Jan 2013, In: Current Drug Metabolism. 14, 1, p. 4-20 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure

Bahnsen, J. S., Franzyk, Henrik, Sandberg-Schaal, A. & Nielsen, Hanne Mørck, 2013, In: B B A - Biomembranes. 1828, 2, p. 223-232 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Biologiske lægemidler - fra molekyle til medicin

Nielsen, Hanne Mørck, Foged, Camilla, Jørgensen, Lene & Frøkjær, Sven, 2013, In: Lægemiddelforskning. p. 12-14

Research output: Contribution to journal › Journal article › Research

Development and rheological profiling of biosimilar mucus

Bøgh, M., Baldursdottir, S. G., Nielsen, M. H., Mullertz, Anette & Nielsen, Hanne Mørck, 2013, In: Nordic Rheology Society Annual Transactions. 21, p. 233-240

Research output: Contribution to journal › Conference article › Research › peer-review

Mucosal drug delivery: barriers, in vitro models and formulation strategies

Bøgh, M., Foged, Camilla, Mullertz, Anette & Nielsen, Hanne Mørck, 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 383-391

Research output: Contribution to journal › Review › Research › peer-review

Peptide-enhanced oral delivery of therapeutic peptides and proteins

Kristensen, Mie, Foged, Camilla, Berthelsen, J. & Nielsen, Hanne Mørck, 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 365-373 9 p.

Research output: Contribution to journal › Review › Research › peer-review

Vaccination i slimhinderne skal forhindre sygdomsfremkaldende mikroorganismer at nå ind i kroppen

Foged, Camilla, Ingvarsson, P. T., Follmann, F., Christensen, D. & Nielsen, Hanne Mørck, 2013, In: Lægemiddelforskning. 2013, p. 41-43

Research output: Contribution to journal › Journal article › Research

Comparison of polymeric siRNA nanocarriers in murine LPS-activated macrophage cell line: Gene silencing, toxicity and off-target gene expression

Jensen, L. B., Griger, J., Naeye, B., Varkouhi, A. K., Raemdonck, K., Schiffelers, R., Lammers, T., Storm, G., Smedt, S. C. D., Sproat, B. S., Nielsen, Hanne Mørck & Foged, Camilla, 2012, In: Pharmaceutical Research. 29, p. 669-682

Research output: Contribution to journal › Journal article › Research › peer-review

Cyclodextrins: efficient biocompatible solubilizing excipients for bromhexine liquid and semi-solid drug delivery systems

Stojanov, M., Nielsen, Hanne Mørck & Larsen, K. L., 2012, In: International Journal of Pharmaceutics. 422, 1-2, p. 349-355

Research output: Contribution to journal › Journal article › Research › peer-review

Delivery of dermatan sulfate from polyelectrolyte complex-containing alginate composite microspheres for tissue regeneration

Wen, Y., Grøndahl, L., Gallego, M. R., Jørgensen, Lene, Møller, E. H. & Nielsen, Hanne Mørck, 2012, In: Biomacromolecules. 13, p. 905-917

Research output: Contribution to journal › Journal article › Research › peer-review

Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNA

Jensen, D. M. K., Jensen, L. B., Koocheki, S., Cun, D., Nielsen, Hanne Mørck, Foged, Camilla & Bengtson, L., 2012, In: Journal of Controlled Release. 157, 1, p. 141-148

Research output: Contribution to journal › Journal article › Research › peer-review

Håb om at ramme latente bakterier i deres skjul

Bahnsen, J. S., Water, J. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2012, In: Lægemiddelforskning 2012. 2012, p. 12-14

Research output: Contribution to journal › Journal article › Research

In vitro placental model optimization for nanoparticle transport studies

Cartwright, L., Poulsen, M. S., Nielsen, Hanne Mørck, Pojana, G., Knudsen, Lisbeth E., Saunders, M. & Rytting, E., 2012, In: International Journal of Nanomedicine (Print). 7, p. 497-510 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

In vitro placental model optimization for nanoparticle transport studies

Cartwright, L., Poulsen, M. S., Nielsen, Hanne Mørck, Pojana, G., Knudsen, Lisbeth E., Saunders, M. & Rytting, E., 2012, In: International Journal of Nanomedicine (Online). 7, p. 497-510

Research output: Contribution to journal › Journal article › Research › peer-review

MRI-assessed therapeutic effects of locally administered PLGA nanoparticles loaded with anti-inflammatory siRNA in a murine arthritis model

Te Boekhorst, B. C. M., Jensen, L. B., Colombo, S., Varkouhi, A. K., Schiffelers, R. M., Lammers, T., Storm, G., Nielsen, Hanne Mørck, Strijkers, G. J., Foged, Camilla & Nicolay, K., 2012, In: Journal of controlled release : official journal of the Controlled Release Society. 161, 3, p. 772-80 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Membrane adsorption and binding, cellular uptake and cytotoxicity of cell-penetrating peptidomimetics with α-peptide/β-peptoid backbone: effects of hydrogen bonding and α-chirality in the β-peptoid residues

Jing, X., Yang, M., Kasimova, M. R., Malmsten, M., Franzyk, Henrik, Jørgensen, Lene, Foged, Camilla & Nielsen, Hanne Mørck, 2012, In: BBA General Subjects. 1818, 11, p. 2660-2668 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Oral delivery of peptides and proteins using lipid-based drug delivery systems

Li, P., Nielsen, Hanne Mørck & Mullertz, Anette , 2012, In: Expert Opinion on Drug Delivery. 9, 10, p. 1289-304 16 p.

Research output: Contribution to journal › Review › Research › peer-review

Solid-phase route to Fmoc-protected cationic amino acid building blocks

Clausen, J. D., Linderoth, L., Nielsen, Hanne Mørck & Franzyk, Henrik, 2012, In: Amino Acids. 43, 4, p. 1633-41 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Structure of immune stimulating complex matrices and immune stimulating complexes in suspension determined by small-angle X-ray scattering

Pedersen, J. S., Oliveira, C. L. P. D., Madsen, H. B., Arleth, Lise, Manniche, S., Kirkby, N. & Nielsen, Hanne Mørck, 2012, In: Biophysical Journal. 102, 10, p. 2372-2380

Research output: Contribution to journal › Journal article › Research › peer-review

Gendannelse af ødelagt væv med stamceller

Møller, E. H., Wen, Y. & Nielsen, Hanne Mørck, Dec 2011, In: Lægemiddelforskning. 2011, p. 13-15

Research output: Contribution to journal › Journal article › Communication

Genetisk nanomedicin til behandling af leddegigt

Foged, Camilla, Jensen, L. B. & Nielsen, Hanne Mørck, Dec 2011, In: Lægemiddelforskning. p. 7-9

Research output: Contribution to journal › Journal article › Communication