CNS Drug Delivery and Barrier Modelling

  1. 2024
  2. Published

    Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution

    Langthaler, Kristine, Jones, C. R., Saaby, Lasse, Bundgaard, C. & Larsen, Birger Brodin, 2024, In: Fluids and Barriers of the CNS. 21, 1, 15 p., 11.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus

    Nielsen, A. K. R., Lilieholm-Røngren, L., Schmid, B., Holst, B., Larsen, Birger Brodin & Saaby, Lasse, 2024, In: Stem Cell Research. 76, 5 p., 103348.

    Research output: Contribution to journalJournal articlepeer-review

  4. 2023
  5. Published

    Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells

    Nielsen, S. S. E., Holst, M. R., Langthaler, Kristine, Bruun, E. H., Larsen, Birger Brodin & Nielsen, M. S., 2023, In: Fluids and Barriers of the CNS. 20, 1, 15 p., 2.

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    Assessing extent of brain penetration in vivo (Kp,uu,brain) in Göttingen minipig using a diverse set of reference drugs

    Langthaler, Kristine, Jones, C. R., Larsen, Birger Brodin & Bundgaard, C., 2023, In: European Journal of Pharmaceutical Sciences. 190, 11 p., 106554.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    Cell-Penetrating Peptides as Tools to Facilitate Oral Delivery of Biopharmaceuticals

    Asgreen, Camilla Jantzen, Fredholt, Freja, Nielsen, Hanne Mørck & Kristensen, Mie, 2023, Cell-Penetrating Peptides: Design, Development and Applications. Oba, M. & Demizu, Y. (eds.). Wiley-VCH, p. 331-354

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  8. Published

    Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line

    Ozgür, Burak, Puris, E., Brachner, A., Appelt-Menzel, A., Oerter, S., Balzer, V., Holst, M. R., Christiansen, R. F., Hyldig, K., Buckley, S. T., Kristensen, Mie, Auriola, S., Jensen, A., Fricker, G., Nielsen, M. S., Neuhaus, W. & Larsen, Birger Brodin, 2023, In: Fluids and Barriers of the CNS. 20, 1, 15 p., 96.

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    Epithelium dynamics differ in time and space when exposed to the permeation enhancers penetramax and EGTA. A head-to-head mechanistic comparison

    Panou, D. A., Pedersen, Stine Helene Falsig, Kristensen, Mie & Nielsen, Hanne Mørck, 2023, In: Frontiers in Drug Delivery. 3, 16 p., 1221628.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Selenomethionine as alternative label to the fluorophore TAMRA when exploiting cell-penetrating peptides as blood-brain barrier shuttles to better mimic the physicochemical properties of the non-labelled peptides

    Ýr Þorgeirsdóttir, D., Hofman Andersen, J., Perch-Nielsen, M., Møller, L. H., Grønbæk-Thorsen, F., Kolberg, Hannah Grønbech, Gammelgaard, Bente & Kristensen, Mie, 2023, In: European Journal of Pharmaceutical Sciences. 183, 10 p., 106400.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier

    Holst, M. R., de Wit, N. M., Ozgür, Burak, Brachner, A., Hyldig, K., Appelt-Menzel, A., Sleven, H., Cader, Z., de Vries, H. E., Neuhaus, W., Jensen, A., Larsen, Birger Brodin & Nielsen, M. S., 2023, In: Fluids and Barriers of the CNS. 20, 1, 17 p., 82.

    Research output: Contribution to journalJournal articlepeer-review

  12. 2022
  13. Published

    Barrier properties of ex vivo porcine intestinal mucus are highly independent of isolation and storage conditions

    Mortensen, Janni Støvring, Saaby, Lasse, Rønholt, Stine & Nielsen, Hanne Mørck, 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 174, p. 106-110

    Research output: Contribution to journalJournal articlepeer-review

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