Christian Janfelt
Christian Janfelt

Associate Professor


  1. 2019
  2. Published

    Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

    Hendel, K. K., Bagger, C., Olesen, U. H., Janfelt, Christian, Hansen, S. H., Hædersdal, Merete & Lerche, C. M., Dec 2019, In : Drug Delivery. 26, 1, p. 244-251 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Quinolizidine alkaloids are transported to seeds of bitter narrow-leafed lupin

    Otterbach, S. L., Yang, T., Kato, L., Janfelt, Christian & Geu-Flores, Fernando, 15 Oct 2019, In : Journal of Experimental Botany. 70, 20, p. 5799-5808

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging

    Clitherow, K. H., Murdoch, C., Spain, S. G., Handler, A. M., Colley, H. E., Stie, Mai Bay, Nielsen, Hanne Mørck, Janfelt, Christian, Hatton, P. V. & Jacobsen, Jette, Sep 2019, In : Molecular Pharmaceutics. 16, 9, p. 3948-3956

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Visualization of the penetration modifying mechanism of laurocapram by Mass Spectrometry Imaging in buccal drug delivery

    Handler, Anne Mette, Marxen, E., Jacobsen, Jette & Janfelt, Christian, 15 Jan 2019, In : European Journal of Pharmaceutical Sciences. 127, p. 276-281 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Characterisation and localisation of the endocannabinoid system components in the adult human testis

    Nielsen, J. E., Rolland, A. D., Rajpert-De Meyts, E., Janfelt, Christian, Jørgensen, A., Winge, S. B., Kristensen, D. M., Juul, Anders, Chalmel, F., Jégou, B. & Skakkebæk, Niels Erik, 2019, In : Scientific Reports. 9, 1, 14 p., 12866.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 2018
  8. Published

    Delivery of amitriptyline by intravenous and intraperitoneal administration compared in the same animal by whole-body mass spectrometry imaging of a stable isotope labelled drug substance in mice

    Morineau, L., Jacobsen, S. C., Kleberg, K., Hansen, Harald S. & Janfelt, Christian, 2 Dec 2018, In : Expert Opinion on Drug Delivery. 15, 12, p. 1157-1163

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Buccal delivery of small molecules - Impact of levulinic acid, oleic acid, sodium dodecyl sulfate and hypotonicity on ex vivo permeability and spatial distribution in mucosa

    Hansen, S. E., Marxen, E., Janfelt, Christian & Jacobsen, Jette, Dec 2018, In : European Journal of Pharmaceutics and Biopharmaceutics. 133, p. 250-257

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    The iP-gp cell model is an improved tool for predicting the in vivo relevance of P-gp mediated efflux at the blood-brain barrier

    Ozgür, Burak, Saaby, L., Eneberg, E., Langthaler, K., Jacobsen, A., Janfelt, Christian, Badolo, L., Montanari, D. & Brodin, Birger, 22 Jun 2018.

    Research output: Contribution to conferencePosterResearchpeer-review

  11. Published

    MALDI imaging of enzymatic degradation of glycerides by lipase on textile surface

    Granborg, Jonatan Riber, Kaasgaard, S. G. & Janfelt, Christian, Mar 2018, In : Chemistry and Physics of Lipids. 211, p. 100-106

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Effect of Permeation Enhancers on the Buccal Permeability of Nicotine: Ex vivo Transport Studies Complemented by MALDI MS Imaging

    Marxen, E., Jin, L., Jacobsen, Jette, Janfelt, Christian, Hyrup, B. & Nicolazzo, J. A., 21 Feb 2018, In : Pharmaceutical Research. 35, 3, 12 p., 70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Permeability Barriers for Nicotine and Mannitol in Porcine Buccal. Mucosa Studied by High-Resolution MALDI Mass Spectrometry Imaging

    Marxen, E., Jacobsen, Jette, Hyrup, B. & Janfelt, Christian, Feb 2018, In : Molecular Pharmaceutics. 15, 2, p. 519-526

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    The Spatial Distribution of Alkaloids in Psychotria prunifolia (Kunth) Steyerm and Palicourea coriacea (Cham.) K. Schum Leaves Analysed by Desorption Electrospray Ionisation Mass Spectrometry Imaging

    Kato, L., Moraes, A. P., de Oliveira, C. M. A., Vaz, B. G., de Almeida Gonçalves, L., E Silva, E. C. & Janfelt, Christian, 2018, In : Phytochemical Analysis. 29, p. 69-76

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    The intracellular localization of the vanillin biosynthetic machinery in pods of Vanilla planifolia

    Gallage, N. J., Jørgensen, Kirsten, Janfelt, Christian, Nielsen, A. J. Z., Naake, T., Dunski, E., Dalsten, Lene, Grisoni, M. & Møller, Birger Lindberg, 2018, In : Plant and Cell Physiology. 59, 2, p. 304-318 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. 2017
  17. Published

    Combination of MALDI-MSI and cassette dosing for evaluation of drug distribution in human skin explant

    Sørensen, I. S., Janfelt, Christian, Nielsen, M. M. B., Mortensen, R. W., Knudsen, N. Ø., Eriksson, A. H., Pedersen, A. J. & Nielsen, K. T., Aug 2017, In : Analytical and Bioanalytical Chemistry. 409, 21, p. 4993-5005 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Fractional laser-assisted topical delivery leads to enhanced, accelerated and deeper cutaneous 5-fluorouracil uptake

    Wenande, E., Olesen, U. H., Nielsen, M. M. B., Janfelt, Christian, Hansen, S. H., Anderson, R. & Hædersdal, Merete, 2017, In : Expert Opinion on Drug Delivery. 14, 3, p. 307-317 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. 2016
  20. Published

    Mass spectrometry imaging of biomarker lipids for phagocytosis and signalling during focal cerebral ischaemia

    Nielsen, M. M. B., Lambertsen, K. L., Clausen, B. H., Meyer, M., Bhandari, D. R., Larsen, S. T., Poulsen, Steen Seier, Spengler, B., Janfelt, Christian & Hansen, Harald S., 22 Dec 2016, In : Scientific Reports. 6, p. 1-14 14 p., 39571.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Fractional laser-assisted drug delivery: Laser channel depth influences biodistribution and skin deposition of methotrexate

    Taudorf, E. H., Lerche, C. M., Erlendsson, A. M., Philipsen, P. A., Hansen, S. H., Janfelt, Christian, Paasch, U., Anderson, R. R. & Hædersdal, Merete, Jul 2016, In : Lasers in Surgery and Medicine. 48, 5, p. 519-529 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Cryo-sectioning of mice for whole-body imaging of drugs and metabolites with desorption electrospray ionization mass spectrometry imaging - a simplified approach

    Okutan, S., Hansen, Harald S. & Janfelt, Christian, Jun 2016, In : Proteomics. 16, 11-12, p. 1633-41 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Aspects of Quantitation in Mass Spectrometry Imaging Investigated on Cryo-Sections of Spiked Tissue Homogenates

    Hansen, H. T. & Janfelt, Christian, 2016, In : Analytical Chemistry. 88, 23, p. 11513−11520 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Characterization of midazolam metabolism in locusts: The role of CYP3A4-like enzyme in the formation of 1'-OH and 4-OH midazolam

    Olsen, L. R., Gabel-Jensen, C., Wubshet, S. G., Kongstad, Kenneth Thermann, Janfelt, Christian, Badolo, L. & Hansen, S. H., 2016, In : Xenobiotica. 46, 2, p. 99–107 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Interspecific variation in localization of hypericins and phloroglucinols in the genus Hypericum as revealed by desorption electrospray ionization mass spectrometry imaging

    Kucharíková, A., Kimáková, K., Janfelt, Christian & Cellárová, E., 2016, In : Physiologia Plantarum. 157, 1, p. 2-12 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. 2015
  27. Published

    DESI-MS imaging of metabolites in various plant materials – a matter of sample preparation

    Kato, L., Rook, F., Møller, Birger Lindberg, Hansen, S. H. & Janfelt, Christian, 2015.

    Research output: Contribution to conferencePosterResearch

  28. Published

    Distribution of terfenadine and its metabolites in locusts studied by desorption electrospray ionization mass spectrometry imaging

    Olsen, L. R., Hansen, S. H. & Janfelt, Christian, 2015, In : Analytical and Bioanalytical Chemistry. 407, 8, p. 2149–2158 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Imaging of plant materials using indirect desorption electrospray ionization mass spectrometry

    Janfelt, Christian, 2015, Mass Spectrometry Imaging of Small Molecules. He, L. (ed.). Humana Press, Vol. 1203. p. 91-7 7 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  30. Published

    Topically applied methotrexate is rapidly delivered into skin by fractional laser ablation

    Taudorf, E. H., Lerche, C., Vissing, A., Philipsen, P. A., Hannibal, J., D'Alvise, U. J. C., Hansen, S. H., Janfelt, Christian, Paasch, U., Anderson, R. R. & Hædersdal, Merete, 2015, In : Expert Opinion on Drug Delivery. 12, 7, p. 1059-1069 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. 2014
  32. Published

    Natural products in Glycyrrhiza glabra (licorice) rhizome imaged at the cellular level by atmospheric pressure matrix-assisted laser desorption/ionization tandem mass spectrometry imaging

    Li, B., Bhandari, D. R., Janfelt, Christian, Römpp, A. & Spengler, B., Oct 2014, In : Plant Journal. 80, 1, p. 161-71 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Studies of an insect model for drug metabolism by Desorption Electrospray Ionization Mass Spectrometry Imaging

    Olsen, L. R., Hansen, S. H. & Janfelt, Christian, Aug 2014.

    Research output: Contribution to conferencePosterResearch

  34. Published

    Detection of follicular transport of lidocaine and metabolism in adipose tissue in pig ear skin by DESI mass spectrometry imaging

    D'Alvise, J., Mortensen, R., Hansen, S. H. & Janfelt, Christian, Jun 2014, In : Analytical and Bioanalytical Chemistry. 406, 15, p. 3735-42 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Azone® decreases the buccal mucosal permeation of Diazepam in a concentration-dependent manner via a reservoir effect

    Meng-Lund, E., Jacobsen, Jette, Jin, L., Janfelt, Christian, Holm, R., Mullertz, Anette & Nicolazzo, J. A., 15 Feb 2014, In : Journal of Pharmaceutical Sciences. 103, 4, p. 1133-1141 103.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Mass spectrometry imaging of plant metabolites – principles and possibilities

    Bjarnholt, Nanna, Li, B., D'Alvise, J. & Janfelt, Christian, 2014, In : Natural Product Reports. 31, 6, p. 818-837 20 p.

    Research output: Contribution to journalReviewResearchpeer-review

  37. 2013
  38. Published

    Displaced dual-mode imaging with desorption electrospray ionization for simultaneous mass spectrometry imaging in both polarities and with several scan modes

    Janfelt, Christian, Wellner, N., Hansen, Harald S. & Hansen, S. H., Mar 2013, In : Journal of Mass Spectrometry. 48, 3, p. 361-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    N-acylation of phosphatidylethanolamine and its biological functions in mammals

    Wellner, N., Diep, T. A., Janfelt, Christian & Hansen, Harald S., Mar 2013, In : BBA General Subjects. 1831, 3, p. 652-62 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Direct imaging of plant metabolites in leaves and petals by Desorption Electrospray Ionization mass spectrometry

    Li, B., Hansen, S. H. & Janfelt, Christian, 2013, In : International Journal of Mass Spectrometry. 348, p. 15-22

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    High-throughput analysis of drugs in biological fluids by desorption electrospray ionization mass spectrometry coupled with thin liquid membrane extraction

    Rosting, C., Pedersen-Bjergaard, Stig, Hansen, S. H. & Janfelt, Christian, 2013, In : Analyst. 138, 20, p. 5965-72 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Visualizing metabolite distribution and enzymatic conversion in plant tissues by desorption electrospray ionization mass spectrometry imaging

    Li, B., Knudsen, Camilla, Hansen, N. K. K., Jørgensen, Kirsten, Kannangara, R. M., Bak, Søren, Takos, A. M., Rook, F., Hansen, S. H., Møller, Birger Lindberg, Janfelt, Christian & Bjarnholt, Nanna, 2013, In : Plant Journal. 74, 6, p. 1059-1071 74.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. 2012
  44. Published

    Ambient mass spectrometry imaging: a comparison of desorption ionization by sonic spray and electrospray

    Janfelt, Christian & Nørgaard, A. W., Oct 2012, In : Journal of The American Society for Mass Spectrometry. 23, 10, p. 1670-8 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Billeddannende massespektrometri

    Janfelt, Christian, D'Alvise, J., Li, B. & Hansen, S. H., 2012, In : Dansk Kemi. 93, 6/7, p. 12-14 3 p.

    Research output: Contribution to journalJournal articleCommunication

  46. Published

    Billeddannende massespektrometri til analyse af vævsprøver

    Janfelt, Christian, Wellner, N., D'Alvise, J. & Hansen, S. H., 2012, In : Dansk Kemi. 93, 8, p. 20-23

    Research output: Contribution to journalJournal articleResearch

  47. Published

    Direct and indirect imaging of secondary metabolites and enzymatic reactions in plant material by Desorption Electrospray Ionization

    Li, B., Bjarnholt, Nanna, Knudsen, Camilla, D'Alvise, J., Hansen, S. H. & Janfelt, Christian, 2012.

    Research output: Contribution to conferencePosterResearchpeer-review

  48. Published

    Ischemia in neonatal rat brains analyzed by Desorption Electrospray Ionization Imaging mass spectrometry

    Janfelt, Christian, Wellner, N., Leger, P., Kokesch-Himmelreich, J., Hansen, S. H., Charriaut-Marlangue, C. & Hansen, Harald S., 2012.

    Research output: Contribution to conferencePosterResearchpeer-review

  49. Published

    Liquid-phase microextraction and desorption electrospray ionization mass spectrometry for identification and quantification of basic drugs in human urine

    Thunig, J., Flø, L., Pedersen-Bjergaard, Stig, Hansen, S. H. & Janfelt, Christian, 2012, In : Rapid Communications in Massspectrometry. 26, 2, p. 133-140

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Portable electrospray ionization mass spectrometry (ESI-MS) for analysis of contaminants in the field

    Janfelt, Christian, Græsbøll, R. & Lauritsen, F. R., 2012, In : International Journal of Environmental Analytical Chemistry. 92, 4, p. 397–404 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Visualization by mass spectrometry of 2-dimensional changes in rat brain lipids, including N-acylphosphatidylethanolamines, during neonatal brain ischemia

    Janfelt, Christian, Wellner, N., Leger, P., Kokesch-Himmelreich, J., Hansen, S. H., Charriaut-Marlangue, C. & Hansen, Harald S., 2012, In : F A S E B Journal. 26, 6, p. 2667-2673

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. 2011
  53. Published

    Massespektrometri viser fordelingen af lægemiddelstoffer i planter og væv

    Janfelt, Christian, Thunig, J., Li, B., Andersen, N. W., Hansen, Harald S. & Hansen, S. H., Dec 2011, In : Lægemiddelforskning. 2011, p. 10-12

    Research output: Contribution to journalJournal articleCommunication

  54. Published

    Analysis of secondary plant metabolites by indirect desorption electrospray ionization imaging mas spectrometry

    Thunig, U. J. C., Hansen, S. H. & Janfelt, Christian, 2011, In : Analytical Chemistry. 83, p. 3256-3259

    Research output: Contribution to journalLetterResearchpeer-review

  55. Published

    Characterization of a capillary spray cell for easy analysis of extracts of biological samples

    Janfelt, Christian & Lauritsen, F. R., 2011, In : International Journal of Mass Spectrometry. 299, p. 178-183

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Characterization of barley leaf tissue using direct and indirect desorption electrospray ionization imaging mass spectrometry

    Li, B., Bjarnholt, Nanna, Hansen, S. H. & Janfelt, Christian, 2011, In : Journal of Mass Spectrometry. 46, 12, p. 1241-1246

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Indirect DESI imaging of secondary metabolites in plant material

    Janfelt, Christian, Thunig, U. J. C., Li, B. & Hansen, S. H., 2011. 1 p.

    Research output: Contribution to conferencePosterResearch

  58. Published

    Nebulization ionization and desorption ionization analysis of reactive organofunctionalized silanes in nanofilm products

    Nørgaard, A. W., Janfelt, Christian, Benassi, M., Wolkoff, P. & Lauritsen, F. R., 2011, In : Journal of Mass Spectrometry. 46, 4, p. 402-410

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. 2010
  60. Published

    Direkte analyse med DESI-MS

    Thunig, J., Lauritsen, F. R., Hansen, S. H., Janfelt, Christian & Christophersen, C., 2010, In : Dansk Kemi. 91, 3, p. 21-23 3 p.

    Research output: Contribution to journalJournal articleResearch

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