USING OXYGEN-CONSUMING THERMOSET PLASTICS TO GENERATE HYPOXIC CONDITIONS IN MICROFLUIDIC DEVICES FOR POTENTIAL CELL CULTURE APPLICATIONS

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Documents

Drago Sticker, Mario Rothbauer, Josef Ehgartner, Christoph Steininger, Winfried Neuhaus, Torsten Mayr, Tommy Haraldsson, Jörg P. Kutter, Peter Ertl

The precise control of the oxygen concentration in a cellular environment allows the study of cells under physiologically relevant conditions. This work reports on a novel method for the generation of reduced dissolved oxygen concentrations in microfluidic chambers for cell- and organ-on-chip applications. Using a thermoset polymeric material (OSTEMERTM), which effectively scavenges dissolved oxygen (DO), microfluidic devices have been fabricated where oxygen was rapidly depleted from the microfluidic chamber. It is shown that hypoxic and anaerobic conditions can be generated through the inherent scavenging property of the material itself, without any additional chemical additives.
Original languageEnglish
Publication dateOct 2017
Number of pages2
Publication statusPublished - Oct 2017
EventThe 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017) - Savannah, Georgia, USA, Savannah, United States
Duration: 22 Oct 201726 Oct 2017

Conference

ConferenceThe 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017)
LocationSavannah, Georgia, USA
CountryUnited States
CitySavannah
Period22/10/201726/10/2017

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