Visualization and Non-Destructive Quantification of Inkjet-Printed Pharmaceuticals on Different Substrates Using Raman Spectroscopy and Raman Chemical Imaging

Research output: Contribution to journalJournal articleResearchpeer-review

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Visualization and Non-Destructive Quantification of Inkjet-Printed Pharmaceuticals on Different Substrates Using Raman Spectroscopy and Raman Chemical Imaging. / Edinger, Magnus; Bar-Shalom, Daniel; Rantanen, Jukka; Genina, Natalja.

In: Pharmaceutical Research, Vol. 34, No. 5, 05.2017, p. 1023-1036.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Edinger, M, Bar-Shalom, D, Rantanen, J & Genina, N 2017, 'Visualization and Non-Destructive Quantification of Inkjet-Printed Pharmaceuticals on Different Substrates Using Raman Spectroscopy and Raman Chemical Imaging', Pharmaceutical Research, vol. 34, no. 5, pp. 1023-1036. https://doi.org/10.1007/s11095-017-2126-2

APA

Edinger, M., Bar-Shalom, D., Rantanen, J., & Genina, N. (2017). Visualization and Non-Destructive Quantification of Inkjet-Printed Pharmaceuticals on Different Substrates Using Raman Spectroscopy and Raman Chemical Imaging. Pharmaceutical Research, 34(5), 1023-1036. https://doi.org/10.1007/s11095-017-2126-2

Vancouver

Edinger M, Bar-Shalom D, Rantanen J, Genina N. Visualization and Non-Destructive Quantification of Inkjet-Printed Pharmaceuticals on Different Substrates Using Raman Spectroscopy and Raman Chemical Imaging. Pharmaceutical Research. 2017 May;34(5):1023-1036. https://doi.org/10.1007/s11095-017-2126-2

Author

Edinger, Magnus ; Bar-Shalom, Daniel ; Rantanen, Jukka ; Genina, Natalja. / Visualization and Non-Destructive Quantification of Inkjet-Printed Pharmaceuticals on Different Substrates Using Raman Spectroscopy and Raman Chemical Imaging. In: Pharmaceutical Research. 2017 ; Vol. 34, No. 5. pp. 1023-1036.

Bibtex

@article{804f1e9436fb42f4ac94db8e214befd9,
title = "Visualization and Non-Destructive Quantification of Inkjet-Printed Pharmaceuticals on Different Substrates Using Raman Spectroscopy and Raman Chemical Imaging",
abstract = "PURPOSE: The purpose of this study was to investigate the applicability of Raman spectroscopy for visualization and quantification of inkjet-printed pharmaceuticals.METHODS: Haloperidol was used as a model active pharmaceutical ingredient (API), and a printable ink base containing lactic acid and ethanol was developed. Inkjet printing technology was used to apply haloperidol ink onto three different substrates. Custom-made inorganic compacts and dry foam, as well as marketed paracetamol tablets were used as the substrates.RESULTS: Therapeutic personalized doses were printed by using one to ten printing rounds on the substrates. The haloperidol content in the finished dosage forms were determined by high-performance liquid chromatography (HPLC). The distribution of the haloperidol on the dosage forms were visualized using Raman chemical imaging combined with principal components analysis (PCA). Raman spectroscopy combined with modeling by partial least squares (PLS) regression was used for establishment of a quantitative model of the haloperidol content in the printed dosage forms. A good prediction of the haloperidol content was achieved for the inorganic compacts, while a slightly poorer prediction was observed for the paracetamol tablets. It was not possible to quantify haloperidol on the dry foam due to the low and varying density of the substrate.CONCLUSIONS: Raman spectroscopy is a useful tool for visualization and quality control of inkjet printed personalized medicine.",
keywords = "Journal Article",
author = "Magnus Edinger and Daniel Bar-Shalom and Jukka Rantanen and Natalja Genina",
year = "2017",
month = "5",
doi = "10.1007/s11095-017-2126-2",
language = "English",
volume = "34",
pages = "1023--1036",
journal = "Pharmaceutical Research",
issn = "0724-8741",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Visualization and Non-Destructive Quantification of Inkjet-Printed Pharmaceuticals on Different Substrates Using Raman Spectroscopy and Raman Chemical Imaging

AU - Edinger, Magnus

AU - Bar-Shalom, Daniel

AU - Rantanen, Jukka

AU - Genina, Natalja

PY - 2017/5

Y1 - 2017/5

N2 - PURPOSE: The purpose of this study was to investigate the applicability of Raman spectroscopy for visualization and quantification of inkjet-printed pharmaceuticals.METHODS: Haloperidol was used as a model active pharmaceutical ingredient (API), and a printable ink base containing lactic acid and ethanol was developed. Inkjet printing technology was used to apply haloperidol ink onto three different substrates. Custom-made inorganic compacts and dry foam, as well as marketed paracetamol tablets were used as the substrates.RESULTS: Therapeutic personalized doses were printed by using one to ten printing rounds on the substrates. The haloperidol content in the finished dosage forms were determined by high-performance liquid chromatography (HPLC). The distribution of the haloperidol on the dosage forms were visualized using Raman chemical imaging combined with principal components analysis (PCA). Raman spectroscopy combined with modeling by partial least squares (PLS) regression was used for establishment of a quantitative model of the haloperidol content in the printed dosage forms. A good prediction of the haloperidol content was achieved for the inorganic compacts, while a slightly poorer prediction was observed for the paracetamol tablets. It was not possible to quantify haloperidol on the dry foam due to the low and varying density of the substrate.CONCLUSIONS: Raman spectroscopy is a useful tool for visualization and quality control of inkjet printed personalized medicine.

AB - PURPOSE: The purpose of this study was to investigate the applicability of Raman spectroscopy for visualization and quantification of inkjet-printed pharmaceuticals.METHODS: Haloperidol was used as a model active pharmaceutical ingredient (API), and a printable ink base containing lactic acid and ethanol was developed. Inkjet printing technology was used to apply haloperidol ink onto three different substrates. Custom-made inorganic compacts and dry foam, as well as marketed paracetamol tablets were used as the substrates.RESULTS: Therapeutic personalized doses were printed by using one to ten printing rounds on the substrates. The haloperidol content in the finished dosage forms were determined by high-performance liquid chromatography (HPLC). The distribution of the haloperidol on the dosage forms were visualized using Raman chemical imaging combined with principal components analysis (PCA). Raman spectroscopy combined with modeling by partial least squares (PLS) regression was used for establishment of a quantitative model of the haloperidol content in the printed dosage forms. A good prediction of the haloperidol content was achieved for the inorganic compacts, while a slightly poorer prediction was observed for the paracetamol tablets. It was not possible to quantify haloperidol on the dry foam due to the low and varying density of the substrate.CONCLUSIONS: Raman spectroscopy is a useful tool for visualization and quality control of inkjet printed personalized medicine.

KW - Journal Article

U2 - 10.1007/s11095-017-2126-2

DO - 10.1007/s11095-017-2126-2

M3 - Journal article

VL - 34

SP - 1023

EP - 1036

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

IS - 5

ER -

ID: 185720978