Using terahertz pulsed spectroscopy to study crystallinity of pharmaceutical materials

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Using terahertz pulsed spectroscopy to study crystallinity of pharmaceutical materials. / Strachan, Clare J.; Rades, Thomas; Newnham, David A.; Gordon, Keith C.; Pepper, Michael; Taday, Philip F.

In: Chemical Physics Letters, Vol. 390, No. 1-3, 21.05.2004, p. 20-24.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Strachan, CJ, Rades, T, Newnham, DA, Gordon, KC, Pepper, M & Taday, PF 2004, 'Using terahertz pulsed spectroscopy to study crystallinity of pharmaceutical materials', Chemical Physics Letters, vol. 390, no. 1-3, pp. 20-24. https://doi.org/10.1016/j.cplett.2004.03.117

APA

Strachan, C. J., Rades, T., Newnham, D. A., Gordon, K. C., Pepper, M., & Taday, P. F. (2004). Using terahertz pulsed spectroscopy to study crystallinity of pharmaceutical materials. Chemical Physics Letters, 390(1-3), 20-24. https://doi.org/10.1016/j.cplett.2004.03.117

Vancouver

Strachan CJ, Rades T, Newnham DA, Gordon KC, Pepper M, Taday PF. Using terahertz pulsed spectroscopy to study crystallinity of pharmaceutical materials. Chemical Physics Letters. 2004 May 21;390(1-3):20-24. https://doi.org/10.1016/j.cplett.2004.03.117

Author

Strachan, Clare J. ; Rades, Thomas ; Newnham, David A. ; Gordon, Keith C. ; Pepper, Michael ; Taday, Philip F. / Using terahertz pulsed spectroscopy to study crystallinity of pharmaceutical materials. In: Chemical Physics Letters. 2004 ; Vol. 390, No. 1-3. pp. 20-24.

Bibtex

@article{858729e5a88941bb85bea4f4bb362814,
title = "Using terahertz pulsed spectroscopy to study crystallinity of pharmaceutical materials",
abstract = "The application of terahertz pulsed spectroscopy to polymorphic, liquid crystalline and amorphous forms of pharmaceutical compounds has been investigated. The different polymorphic forms of carbamazepine and enalapril maleate exhibit distinct terahertz absorbance spectra. In contrast to crystalline indomethacin and fenoprofen calcium, amorphous indomethacin and liquid crystalline fenoprofen calcium show no absorption modes, which is likely to be due to a lack of order. These findings suggest that the modes observed are due to crystalline phonon and possibly hydrogen-bonding vibrations. The large spectral differences between different forms of the compounds studied is evidence that terahertz pulsed spectroscopy is well-suited to distinguishing crystallinity differences in pharmaceutical compounds.",
author = "Strachan, {Clare J.} and Thomas Rades and Newnham, {David A.} and Gordon, {Keith C.} and Michael Pepper and Taday, {Philip F.}",
year = "2004",
month = may,
day = "21",
doi = "10.1016/j.cplett.2004.03.117",
language = "English",
volume = "390",
pages = "20--24",
journal = "Chemical Physics Letters",
issn = "0009-2614",
publisher = "Elsevier",
number = "1-3",

}

RIS

TY - JOUR

T1 - Using terahertz pulsed spectroscopy to study crystallinity of pharmaceutical materials

AU - Strachan, Clare J.

AU - Rades, Thomas

AU - Newnham, David A.

AU - Gordon, Keith C.

AU - Pepper, Michael

AU - Taday, Philip F.

PY - 2004/5/21

Y1 - 2004/5/21

N2 - The application of terahertz pulsed spectroscopy to polymorphic, liquid crystalline and amorphous forms of pharmaceutical compounds has been investigated. The different polymorphic forms of carbamazepine and enalapril maleate exhibit distinct terahertz absorbance spectra. In contrast to crystalline indomethacin and fenoprofen calcium, amorphous indomethacin and liquid crystalline fenoprofen calcium show no absorption modes, which is likely to be due to a lack of order. These findings suggest that the modes observed are due to crystalline phonon and possibly hydrogen-bonding vibrations. The large spectral differences between different forms of the compounds studied is evidence that terahertz pulsed spectroscopy is well-suited to distinguishing crystallinity differences in pharmaceutical compounds.

AB - The application of terahertz pulsed spectroscopy to polymorphic, liquid crystalline and amorphous forms of pharmaceutical compounds has been investigated. The different polymorphic forms of carbamazepine and enalapril maleate exhibit distinct terahertz absorbance spectra. In contrast to crystalline indomethacin and fenoprofen calcium, amorphous indomethacin and liquid crystalline fenoprofen calcium show no absorption modes, which is likely to be due to a lack of order. These findings suggest that the modes observed are due to crystalline phonon and possibly hydrogen-bonding vibrations. The large spectral differences between different forms of the compounds studied is evidence that terahertz pulsed spectroscopy is well-suited to distinguishing crystallinity differences in pharmaceutical compounds.

UR - http://www.scopus.com/inward/record.url?scp=2342488092&partnerID=8YFLogxK

U2 - 10.1016/j.cplett.2004.03.117

DO - 10.1016/j.cplett.2004.03.117

M3 - Journal article

AN - SCOPUS:2342488092

VL - 390

SP - 20

EP - 24

JO - Chemical Physics Letters

JF - Chemical Physics Letters

SN - 0009-2614

IS - 1-3

ER -

ID: 299428872