Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity

Research output: Contribution to journalJournal articlepeer-review

Standard

Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity. / Strachan, Clare J.; Taday, Philip F.; Newnham, David A.; Gordon, Keith C.; Zeitler, J. Axel; Pepper, Michael; Rades, Thomas.

In: Journal of Pharmaceutical Sciences, Vol. 94, No. 4, 04.2005, p. 837-846.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Strachan, CJ, Taday, PF, Newnham, DA, Gordon, KC, Zeitler, JA, Pepper, M & Rades, T 2005, 'Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity', Journal of Pharmaceutical Sciences, vol. 94, no. 4, pp. 837-846. https://doi.org/10.1002/jps.20281

APA

Strachan, C. J., Taday, P. F., Newnham, D. A., Gordon, K. C., Zeitler, J. A., Pepper, M., & Rades, T. (2005). Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity. Journal of Pharmaceutical Sciences, 94(4), 837-846. https://doi.org/10.1002/jps.20281

Vancouver

Strachan CJ, Taday PF, Newnham DA, Gordon KC, Zeitler JA, Pepper M et al. Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity. Journal of Pharmaceutical Sciences. 2005 Apr;94(4):837-846. https://doi.org/10.1002/jps.20281

Author

Strachan, Clare J. ; Taday, Philip F. ; Newnham, David A. ; Gordon, Keith C. ; Zeitler, J. Axel ; Pepper, Michael ; Rades, Thomas. / Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity. In: Journal of Pharmaceutical Sciences. 2005 ; Vol. 94, No. 4. pp. 837-846.

Bibtex

@article{c075f0eebd40494198117ac980e50a5a,
title = "Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity",
abstract = "Terahertz pulsed spectroscopy (TPS) is a new technique that is capable of eliciting rich information when investigating pharmaceutical materials. In solids, it probes long-range crystalline lattice vibrations and low energy torsion and hydrogen bonding vibrations. These properties make TPS potentially an ideal tool to investigate crystallinity and polymorphism. In this study four drugs with different solid-state properties were analyzed using TPS and levels of polymorphism and crystallinity were quantified. Carbamazepine and enalapril maleate polymorphs, amorphous, and crystalline indomethacin, and thermotropic liquid crystalline and crystalline fenoprofen calcium mixtures were quantified using partial least-squares analysis. Root-mean-squared errors of cross validation as low as 0.349% and limits of detection as low as approximately 1% were obtained, demonstrating that TPS is an analytical technique of potential in quantifying solid-state properties of pharmaceutical compounds.",
keywords = "Amorphous, Carbamazepine, Crystallinity, Enalapril maleate, Fenoprofen calcium, Indomethacin, Infrared spectroscopy, Partial least squares, Polymorphism",
author = "Strachan, {Clare J.} and Taday, {Philip F.} and Newnham, {David A.} and Gordon, {Keith C.} and Zeitler, {J. Axel} and Michael Pepper and Thomas Rades",
year = "2005",
month = apr,
doi = "10.1002/jps.20281",
language = "English",
volume = "94",
pages = "837--846",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity

AU - Strachan, Clare J.

AU - Taday, Philip F.

AU - Newnham, David A.

AU - Gordon, Keith C.

AU - Zeitler, J. Axel

AU - Pepper, Michael

AU - Rades, Thomas

PY - 2005/4

Y1 - 2005/4

N2 - Terahertz pulsed spectroscopy (TPS) is a new technique that is capable of eliciting rich information when investigating pharmaceutical materials. In solids, it probes long-range crystalline lattice vibrations and low energy torsion and hydrogen bonding vibrations. These properties make TPS potentially an ideal tool to investigate crystallinity and polymorphism. In this study four drugs with different solid-state properties were analyzed using TPS and levels of polymorphism and crystallinity were quantified. Carbamazepine and enalapril maleate polymorphs, amorphous, and crystalline indomethacin, and thermotropic liquid crystalline and crystalline fenoprofen calcium mixtures were quantified using partial least-squares analysis. Root-mean-squared errors of cross validation as low as 0.349% and limits of detection as low as approximately 1% were obtained, demonstrating that TPS is an analytical technique of potential in quantifying solid-state properties of pharmaceutical compounds.

AB - Terahertz pulsed spectroscopy (TPS) is a new technique that is capable of eliciting rich information when investigating pharmaceutical materials. In solids, it probes long-range crystalline lattice vibrations and low energy torsion and hydrogen bonding vibrations. These properties make TPS potentially an ideal tool to investigate crystallinity and polymorphism. In this study four drugs with different solid-state properties were analyzed using TPS and levels of polymorphism and crystallinity were quantified. Carbamazepine and enalapril maleate polymorphs, amorphous, and crystalline indomethacin, and thermotropic liquid crystalline and crystalline fenoprofen calcium mixtures were quantified using partial least-squares analysis. Root-mean-squared errors of cross validation as low as 0.349% and limits of detection as low as approximately 1% were obtained, demonstrating that TPS is an analytical technique of potential in quantifying solid-state properties of pharmaceutical compounds.

KW - Amorphous

KW - Carbamazepine

KW - Crystallinity

KW - Enalapril maleate

KW - Fenoprofen calcium

KW - Indomethacin

KW - Infrared spectroscopy

KW - Partial least squares

KW - Polymorphism

UR - http://www.scopus.com/inward/record.url?scp=17744372736&partnerID=8YFLogxK

U2 - 10.1002/jps.20281

DO - 10.1002/jps.20281

M3 - Journal article

C2 - 15736195

AN - SCOPUS:17744372736

VL - 94

SP - 837

EP - 846

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 4

ER -

ID: 299428191