Using Potentiometric Free Drug Sensors to Determine the Free Concentration of Ionizable Drugs in Colloidal Systems

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Using Potentiometric Free Drug Sensors to Determine the Free Concentration of Ionizable Drugs in Colloidal Systems. / Tran, Thuy; Chakraborty, Anjan; Xi, Xi; Bohets, Hugo; Cornett, Claus; Tsinman, Konstantin; Rades, Thomas; Müllertz, Anette.

In: Journal of Pharmaceutical Sciences, Vol. 107, No. 1, 01.2018, p. 103-112.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Tran, T, Chakraborty, A, Xi, X, Bohets, H, Cornett, C, Tsinman, K, Rades, T & Müllertz, A 2018, 'Using Potentiometric Free Drug Sensors to Determine the Free Concentration of Ionizable Drugs in Colloidal Systems', Journal of Pharmaceutical Sciences, vol. 107, no. 1, pp. 103-112. https://doi.org/10.1016/j.xphs.2017.05.016

APA

Tran, T., Chakraborty, A., Xi, X., Bohets, H., Cornett, C., Tsinman, K., ... Müllertz, A. (2018). Using Potentiometric Free Drug Sensors to Determine the Free Concentration of Ionizable Drugs in Colloidal Systems. Journal of Pharmaceutical Sciences, 107(1), 103-112. https://doi.org/10.1016/j.xphs.2017.05.016

Vancouver

Tran T, Chakraborty A, Xi X, Bohets H, Cornett C, Tsinman K et al. Using Potentiometric Free Drug Sensors to Determine the Free Concentration of Ionizable Drugs in Colloidal Systems. Journal of Pharmaceutical Sciences. 2018 Jan;107(1):103-112. https://doi.org/10.1016/j.xphs.2017.05.016

Author

Tran, Thuy ; Chakraborty, Anjan ; Xi, Xi ; Bohets, Hugo ; Cornett, Claus ; Tsinman, Konstantin ; Rades, Thomas ; Müllertz, Anette. / Using Potentiometric Free Drug Sensors to Determine the Free Concentration of Ionizable Drugs in Colloidal Systems. In: Journal of Pharmaceutical Sciences. 2018 ; Vol. 107, No. 1. pp. 103-112.

Bibtex

@article{565a67c62d0c4c53abf6b29407b2ec61,
title = "Using Potentiometric Free Drug Sensors to Determine the Free Concentration of Ionizable Drugs in Colloidal Systems",
abstract = "The present study investigates the use of free drug sensors (FDS) to measure free ionized drug concentrations in colloidal systems, including micellar solutions, emulsions, and lipid formulations during in vitro lipolysis. Diphenhydramine hydrochloride (DPH) and loperamide hydrochloride (LOP) were selected as model drugs. Self-diffusion nuclear magnetic resonance studies were performed and confirmed the entrapment of drugs in micelles in Brij 35 and sodium taurodeoxycholate (TDC)/phosphatidylcholine (PC) micellar solutions. The FDS measurements indicated that with a constant level of drug, the percentage of free DPH and LOP decreased from 84{\%} to 57{\%} and from 51{\%} to 18{\%}, respectively, as the concentration of Brij 35 was increased from 4.7 to 22 mM; and from 99{\%} to 46{\%} and from 100{\%} to 21{\%}, respectively, as the concentration of TDC/PC was increased from 0.49/0.04 to 8.85/0.78 mM. During the in vitro lipolysis of a lipid formulation, free drug concentration decreased with lipolysis time. The percentage of free DPH was higher than for LOP in the same colloidal system because DPH is less lipophilic than LOP. The study showed that FDS can be used to monitor the free drug concentration in colloidal systems with fast response, no sample treatment and simple data analysis.",
keywords = "Journal Article",
author = "Thuy Tran and Anjan Chakraborty and Xi Xi and Hugo Bohets and Claus Cornett and Konstantin Tsinman and Thomas Rades and Anette M{\"u}llertz",
note = "Copyright {\circledC} 2017 American Pharmacists Association{\circledR}. Published by Elsevier Inc. All rights reserved.",
year = "2018",
month = "1",
doi = "10.1016/j.xphs.2017.05.016",
language = "English",
volume = "107",
pages = "103--112",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Using Potentiometric Free Drug Sensors to Determine the Free Concentration of Ionizable Drugs in Colloidal Systems

AU - Tran, Thuy

AU - Chakraborty, Anjan

AU - Xi, Xi

AU - Bohets, Hugo

AU - Cornett, Claus

AU - Tsinman, Konstantin

AU - Rades, Thomas

AU - Müllertz, Anette

N1 - Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

PY - 2018/1

Y1 - 2018/1

N2 - The present study investigates the use of free drug sensors (FDS) to measure free ionized drug concentrations in colloidal systems, including micellar solutions, emulsions, and lipid formulations during in vitro lipolysis. Diphenhydramine hydrochloride (DPH) and loperamide hydrochloride (LOP) were selected as model drugs. Self-diffusion nuclear magnetic resonance studies were performed and confirmed the entrapment of drugs in micelles in Brij 35 and sodium taurodeoxycholate (TDC)/phosphatidylcholine (PC) micellar solutions. The FDS measurements indicated that with a constant level of drug, the percentage of free DPH and LOP decreased from 84% to 57% and from 51% to 18%, respectively, as the concentration of Brij 35 was increased from 4.7 to 22 mM; and from 99% to 46% and from 100% to 21%, respectively, as the concentration of TDC/PC was increased from 0.49/0.04 to 8.85/0.78 mM. During the in vitro lipolysis of a lipid formulation, free drug concentration decreased with lipolysis time. The percentage of free DPH was higher than for LOP in the same colloidal system because DPH is less lipophilic than LOP. The study showed that FDS can be used to monitor the free drug concentration in colloidal systems with fast response, no sample treatment and simple data analysis.

AB - The present study investigates the use of free drug sensors (FDS) to measure free ionized drug concentrations in colloidal systems, including micellar solutions, emulsions, and lipid formulations during in vitro lipolysis. Diphenhydramine hydrochloride (DPH) and loperamide hydrochloride (LOP) were selected as model drugs. Self-diffusion nuclear magnetic resonance studies were performed and confirmed the entrapment of drugs in micelles in Brij 35 and sodium taurodeoxycholate (TDC)/phosphatidylcholine (PC) micellar solutions. The FDS measurements indicated that with a constant level of drug, the percentage of free DPH and LOP decreased from 84% to 57% and from 51% to 18%, respectively, as the concentration of Brij 35 was increased from 4.7 to 22 mM; and from 99% to 46% and from 100% to 21%, respectively, as the concentration of TDC/PC was increased from 0.49/0.04 to 8.85/0.78 mM. During the in vitro lipolysis of a lipid formulation, free drug concentration decreased with lipolysis time. The percentage of free DPH was higher than for LOP in the same colloidal system because DPH is less lipophilic than LOP. The study showed that FDS can be used to monitor the free drug concentration in colloidal systems with fast response, no sample treatment and simple data analysis.

KW - Journal Article

U2 - 10.1016/j.xphs.2017.05.016

DO - 10.1016/j.xphs.2017.05.016

M3 - Journal article

C2 - 28549906

VL - 107

SP - 103

EP - 112

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 1

ER -

ID: 185405268