Using 3D Printing for Rapid Prototyping of Characterization Tools for Investigating Powder Blend Behavior

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Using 3D Printing for Rapid Prototyping of Characterization Tools for Investigating Powder Blend Behavior. / Hirschberg, Cosima; Boetker, Johan P; Rantanen, Jukka; Pein-Hackelbusch, Miriam.

In: AAPS PharmSciTech, Vol. 19, No. 2, 2018, p. 941–950.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Hirschberg, C, Boetker, JP, Rantanen, J & Pein-Hackelbusch, M 2018, 'Using 3D Printing for Rapid Prototyping of Characterization Tools for Investigating Powder Blend Behavior', AAPS PharmSciTech, vol. 19, no. 2, pp. 941–950. https://doi.org/10.1208/s12249-017-0904-0

APA

Hirschberg, C., Boetker, J. P., Rantanen, J., & Pein-Hackelbusch, M. (2018). Using 3D Printing for Rapid Prototyping of Characterization Tools for Investigating Powder Blend Behavior. AAPS PharmSciTech, 19(2), 941–950. https://doi.org/10.1208/s12249-017-0904-0

Vancouver

Hirschberg C, Boetker JP, Rantanen J, Pein-Hackelbusch M. Using 3D Printing for Rapid Prototyping of Characterization Tools for Investigating Powder Blend Behavior. AAPS PharmSciTech. 2018;19(2):941–950. https://doi.org/10.1208/s12249-017-0904-0

Author

Hirschberg, Cosima ; Boetker, Johan P ; Rantanen, Jukka ; Pein-Hackelbusch, Miriam. / Using 3D Printing for Rapid Prototyping of Characterization Tools for Investigating Powder Blend Behavior. In: AAPS PharmSciTech. 2018 ; Vol. 19, No. 2. pp. 941–950.

Bibtex

@article{79acf74691804fcc91c064e62cf3d7cb,
title = "Using 3D Printing for Rapid Prototyping of Characterization Tools for Investigating Powder Blend Behavior",
abstract = "There is an increasing need to provide more detailed insight into the behavior of particulate systems. The current powder characterization tools are developed empirically and in many cases, modification of existing equipment is difficult. More flexible tools are needed to provide understanding of complex powder behavior, such as mixing process and segregation phenomenon. An approach based on the fast prototyping of new powder handling geometries and interfacing solutions for process analytical tools is reported. This study utilized 3D printing for rapid prototyping of customized geometries; overall goal was to assess mixing process of powder blends at small-scale with a combination of spectroscopic and mechanical monitoring. As part of the segregation evaluation studies, the flowability of three different paracetamol/filler-blends at different ratios was investigated, inter alia to define the percolation thresholds. Blends with a paracetamol wt{\%} above the percolation threshold were subsequently investigated in relation to their segregation behavior. Rapid prototyping using 3D printing allowed designing two funnels with tailored flow behavior (funnel flow) of model formulations, which could be monitored with an in-line near-infrared (NIR) spectrometer. Calculating the root mean square (RMS) of the scores of the two first principal components of the NIR spectra visualized spectral variation as a function of process time. In a same setup, mechanical properties (basic flow energy) of the powder blend were monitored during blending. Rapid prototyping allowed for fast modification of powder testing geometries and easy interfacing with process analytical tools, opening new possibilities for more detailed powder characterization.",
keywords = "Journal Article",
author = "Cosima Hirschberg and Boetker, {Johan P} and Jukka Rantanen and Miriam Pein-Hackelbusch",
year = "2018",
doi = "10.1208/s12249-017-0904-0",
language = "English",
volume = "19",
pages = "941–950",
journal = "A A P S PharmSciTech",
issn = "1530-9932",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Using 3D Printing for Rapid Prototyping of Characterization Tools for Investigating Powder Blend Behavior

AU - Hirschberg, Cosima

AU - Boetker, Johan P

AU - Rantanen, Jukka

AU - Pein-Hackelbusch, Miriam

PY - 2018

Y1 - 2018

N2 - There is an increasing need to provide more detailed insight into the behavior of particulate systems. The current powder characterization tools are developed empirically and in many cases, modification of existing equipment is difficult. More flexible tools are needed to provide understanding of complex powder behavior, such as mixing process and segregation phenomenon. An approach based on the fast prototyping of new powder handling geometries and interfacing solutions for process analytical tools is reported. This study utilized 3D printing for rapid prototyping of customized geometries; overall goal was to assess mixing process of powder blends at small-scale with a combination of spectroscopic and mechanical monitoring. As part of the segregation evaluation studies, the flowability of three different paracetamol/filler-blends at different ratios was investigated, inter alia to define the percolation thresholds. Blends with a paracetamol wt% above the percolation threshold were subsequently investigated in relation to their segregation behavior. Rapid prototyping using 3D printing allowed designing two funnels with tailored flow behavior (funnel flow) of model formulations, which could be monitored with an in-line near-infrared (NIR) spectrometer. Calculating the root mean square (RMS) of the scores of the two first principal components of the NIR spectra visualized spectral variation as a function of process time. In a same setup, mechanical properties (basic flow energy) of the powder blend were monitored during blending. Rapid prototyping allowed for fast modification of powder testing geometries and easy interfacing with process analytical tools, opening new possibilities for more detailed powder characterization.

AB - There is an increasing need to provide more detailed insight into the behavior of particulate systems. The current powder characterization tools are developed empirically and in many cases, modification of existing equipment is difficult. More flexible tools are needed to provide understanding of complex powder behavior, such as mixing process and segregation phenomenon. An approach based on the fast prototyping of new powder handling geometries and interfacing solutions for process analytical tools is reported. This study utilized 3D printing for rapid prototyping of customized geometries; overall goal was to assess mixing process of powder blends at small-scale with a combination of spectroscopic and mechanical monitoring. As part of the segregation evaluation studies, the flowability of three different paracetamol/filler-blends at different ratios was investigated, inter alia to define the percolation thresholds. Blends with a paracetamol wt% above the percolation threshold were subsequently investigated in relation to their segregation behavior. Rapid prototyping using 3D printing allowed designing two funnels with tailored flow behavior (funnel flow) of model formulations, which could be monitored with an in-line near-infrared (NIR) spectrometer. Calculating the root mean square (RMS) of the scores of the two first principal components of the NIR spectra visualized spectral variation as a function of process time. In a same setup, mechanical properties (basic flow energy) of the powder blend were monitored during blending. Rapid prototyping allowed for fast modification of powder testing geometries and easy interfacing with process analytical tools, opening new possibilities for more detailed powder characterization.

KW - Journal Article

U2 - 10.1208/s12249-017-0904-0

DO - 10.1208/s12249-017-0904-0

M3 - Journal article

C2 - 29098643

VL - 19

SP - 941

EP - 950

JO - A A P S PharmSciTech

JF - A A P S PharmSciTech

SN - 1530-9932

IS - 2

ER -

ID: 185402565