Unidirectional drug release from 3D printed mucoadhesive buccal films using FDM technology: In vitro and ex vivo evaluation

Research output: Contribution to journalJournal article

Standard

Unidirectional drug release from 3D printed mucoadhesive buccal films using FDM technology : In vitro and ex vivo evaluation. / Eleftheriadis, Georgios K.; Ritzoulis, Christos; Bouropoulos, Nikolaos; Tzetzis, Dimitrios; Andreadis, Dimitrios A.; Boetker, Johan; Rantanen, Jukka; Fatouros, Dimitrios G.

In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 144, 11.2019, p. 180-192.

Research output: Contribution to journalJournal article

Harvard

Eleftheriadis, GK, Ritzoulis, C, Bouropoulos, N, Tzetzis, D, Andreadis, DA, Boetker, J, Rantanen, J & Fatouros, DG 2019, 'Unidirectional drug release from 3D printed mucoadhesive buccal films using FDM technology: In vitro and ex vivo evaluation', European Journal of Pharmaceutics and Biopharmaceutics, vol. 144, pp. 180-192. https://doi.org/10.1016/j.ejpb.2019.09.018

APA

Eleftheriadis, G. K., Ritzoulis, C., Bouropoulos, N., Tzetzis, D., Andreadis, D. A., Boetker, J., ... Fatouros, D. G. (2019). Unidirectional drug release from 3D printed mucoadhesive buccal films using FDM technology: In vitro and ex vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics, 144, 180-192. https://doi.org/10.1016/j.ejpb.2019.09.018

Vancouver

Eleftheriadis GK, Ritzoulis C, Bouropoulos N, Tzetzis D, Andreadis DA, Boetker J et al. Unidirectional drug release from 3D printed mucoadhesive buccal films using FDM technology: In vitro and ex vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics. 2019 Nov;144:180-192. https://doi.org/10.1016/j.ejpb.2019.09.018

Author

Eleftheriadis, Georgios K. ; Ritzoulis, Christos ; Bouropoulos, Nikolaos ; Tzetzis, Dimitrios ; Andreadis, Dimitrios A. ; Boetker, Johan ; Rantanen, Jukka ; Fatouros, Dimitrios G. / Unidirectional drug release from 3D printed mucoadhesive buccal films using FDM technology : In vitro and ex vivo evaluation. In: European Journal of Pharmaceutics and Biopharmaceutics. 2019 ; Vol. 144. pp. 180-192.

Bibtex

@article{372534df8a18486cb07c5523e2bea93a,
title = "Unidirectional drug release from 3D printed mucoadhesive buccal films using FDM technology: In vitro and ex vivo evaluation",
abstract = "Oromucosal delivery of active pharmaceutical ingredients provides an attractive alternative route of administration, due to avoidance of the first pass effect and improved patient compliance. In the current work, fused deposition modelling (FDM) 3D printing was investigated as an additive manufacturing approach for poly(vinyl alcohol)-based mucoadhesive films, enabling unidirectional drug release. For this purpose, chitosan was incorporated as a permeation and mucoadhesion enhancer whereas ethylcellulose and commercial wafer sheets were evaluated as backing layers. The formulated films were initially assessed for structural integrity and dose uniformity. Solid-state characterization of the films, including thermal methods (DSC, TGA), diffraction (XRPD) and Raman spectroscopy, was implemented to characterize the physicochemical properties of the produced polymeric filaments and buccal films. The mechanical properties of the products were investigated by instrumented indentation and tensile tests. Evaluation of buccal films was assessed in vitro, to study the effect of backing-layer type on hydration capacity of the films, diffusion of the drug throughout the restricting layer and release profiles in simulated saliva. The ex vivo performance of the manufactured products, associated with the presence of chitosan, was investigated by textural analysis for mucoadhesion properties, whereas permeation studies and histological studies were performed across porcine buccal epithelium. The results demonstrated that FDM printing is a timesaving and versatile approach in the context of manufacturing multi-layered mucoadhesive buccal films, providing unidirectional release properties.",
keywords = "3D printing, Backing layer, Buccal, Chitosan, Diclofenac, FDM, Mucoadhesion, Unidirectional",
author = "Eleftheriadis, {Georgios K.} and Christos Ritzoulis and Nikolaos Bouropoulos and Dimitrios Tzetzis and Andreadis, {Dimitrios A.} and Johan Boetker and Jukka Rantanen and Fatouros, {Dimitrios G.}",
year = "2019",
month = "11",
doi = "10.1016/j.ejpb.2019.09.018",
language = "English",
volume = "144",
pages = "180--192",
journal = "European Journal of Pharmaceutics and Biopharmaceutics",
issn = "0939-6411",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Unidirectional drug release from 3D printed mucoadhesive buccal films using FDM technology

T2 - In vitro and ex vivo evaluation

AU - Eleftheriadis, Georgios K.

AU - Ritzoulis, Christos

AU - Bouropoulos, Nikolaos

AU - Tzetzis, Dimitrios

AU - Andreadis, Dimitrios A.

AU - Boetker, Johan

AU - Rantanen, Jukka

AU - Fatouros, Dimitrios G.

PY - 2019/11

Y1 - 2019/11

N2 - Oromucosal delivery of active pharmaceutical ingredients provides an attractive alternative route of administration, due to avoidance of the first pass effect and improved patient compliance. In the current work, fused deposition modelling (FDM) 3D printing was investigated as an additive manufacturing approach for poly(vinyl alcohol)-based mucoadhesive films, enabling unidirectional drug release. For this purpose, chitosan was incorporated as a permeation and mucoadhesion enhancer whereas ethylcellulose and commercial wafer sheets were evaluated as backing layers. The formulated films were initially assessed for structural integrity and dose uniformity. Solid-state characterization of the films, including thermal methods (DSC, TGA), diffraction (XRPD) and Raman spectroscopy, was implemented to characterize the physicochemical properties of the produced polymeric filaments and buccal films. The mechanical properties of the products were investigated by instrumented indentation and tensile tests. Evaluation of buccal films was assessed in vitro, to study the effect of backing-layer type on hydration capacity of the films, diffusion of the drug throughout the restricting layer and release profiles in simulated saliva. The ex vivo performance of the manufactured products, associated with the presence of chitosan, was investigated by textural analysis for mucoadhesion properties, whereas permeation studies and histological studies were performed across porcine buccal epithelium. The results demonstrated that FDM printing is a timesaving and versatile approach in the context of manufacturing multi-layered mucoadhesive buccal films, providing unidirectional release properties.

AB - Oromucosal delivery of active pharmaceutical ingredients provides an attractive alternative route of administration, due to avoidance of the first pass effect and improved patient compliance. In the current work, fused deposition modelling (FDM) 3D printing was investigated as an additive manufacturing approach for poly(vinyl alcohol)-based mucoadhesive films, enabling unidirectional drug release. For this purpose, chitosan was incorporated as a permeation and mucoadhesion enhancer whereas ethylcellulose and commercial wafer sheets were evaluated as backing layers. The formulated films were initially assessed for structural integrity and dose uniformity. Solid-state characterization of the films, including thermal methods (DSC, TGA), diffraction (XRPD) and Raman spectroscopy, was implemented to characterize the physicochemical properties of the produced polymeric filaments and buccal films. The mechanical properties of the products were investigated by instrumented indentation and tensile tests. Evaluation of buccal films was assessed in vitro, to study the effect of backing-layer type on hydration capacity of the films, diffusion of the drug throughout the restricting layer and release profiles in simulated saliva. The ex vivo performance of the manufactured products, associated with the presence of chitosan, was investigated by textural analysis for mucoadhesion properties, whereas permeation studies and histological studies were performed across porcine buccal epithelium. The results demonstrated that FDM printing is a timesaving and versatile approach in the context of manufacturing multi-layered mucoadhesive buccal films, providing unidirectional release properties.

KW - 3D printing

KW - Backing layer

KW - Buccal

KW - Chitosan

KW - Diclofenac

KW - FDM

KW - Mucoadhesion

KW - Unidirectional

UR - http://www.scopus.com/inward/record.url?scp=85072581122&partnerID=8YFLogxK

U2 - 10.1016/j.ejpb.2019.09.018

DO - 10.1016/j.ejpb.2019.09.018

M3 - Journal article

C2 - 31550525

AN - SCOPUS:85072581122

VL - 144

SP - 180

EP - 192

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

SN - 0939-6411

ER -

ID: 231407944