The Use of 3D Printed Molds to Cast Tablets with a Designed Disintegration Profile
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The Use of 3D Printed Molds to Cast Tablets with a Designed Disintegration Profile. / Ajmal, Adil; Meskarzadeh, Ammon; Genina, Natalja; Hirschberg, Cosima; Boetker, Johan Peter; Rantanen, Jukka.
In: AAPS PharmSciTech, Vol. 20, No. 3, 127, 26.02.2019.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The Use of 3D Printed Molds to Cast Tablets with a Designed Disintegration Profile
AU - Ajmal, Adil
AU - Meskarzadeh, Ammon
AU - Genina, Natalja
AU - Hirschberg, Cosima
AU - Boetker, Johan Peter
AU - Rantanen, Jukka
PY - 2019/2/26
Y1 - 2019/2/26
N2 - Development of new product design principles is crucial for obtaining pharmaceutical products with controlled functionality. Four different molds were designed using a computer-aided design (CAD) software and 3D printed with polylactic acid (PLA). A hydroxypropyl methylcellulose (HPMC) and polyethylene glycol (PEG)-based formulation containing indomethacin as the active pharmaceutical ingredient (API) was casted into the molds. Each mold produced a tablet that was designed to disintegrate into a defined number of sections (2, 4, and 6). This was achieved by incorporating break lines (regions that were significantly thinner than the remainder of the tablet) to control the disintegration process. Disintegration and drug release from these designed tablets was contrasted with a casted tablet without break lines. Disintegration studies confirmed that the casted tablets disintegrated according to their design. Drug-release studies meanwhile demonstrated that tablets with a greater number of sections released the API at a faster rate than those with fewer sections; for example, the 6-sectioned tablet released the API at twice the rate of the tablet without any break lines. It is expected that by using this concept, it would be possible to produce tablets with a designed disintegration profile, which could potentially allow the tailoring of the drug release.
AB - Development of new product design principles is crucial for obtaining pharmaceutical products with controlled functionality. Four different molds were designed using a computer-aided design (CAD) software and 3D printed with polylactic acid (PLA). A hydroxypropyl methylcellulose (HPMC) and polyethylene glycol (PEG)-based formulation containing indomethacin as the active pharmaceutical ingredient (API) was casted into the molds. Each mold produced a tablet that was designed to disintegrate into a defined number of sections (2, 4, and 6). This was achieved by incorporating break lines (regions that were significantly thinner than the remainder of the tablet) to control the disintegration process. Disintegration and drug release from these designed tablets was contrasted with a casted tablet without break lines. Disintegration studies confirmed that the casted tablets disintegrated according to their design. Drug-release studies meanwhile demonstrated that tablets with a greater number of sections released the API at a faster rate than those with fewer sections; for example, the 6-sectioned tablet released the API at twice the rate of the tablet without any break lines. It is expected that by using this concept, it would be possible to produce tablets with a designed disintegration profile, which could potentially allow the tailoring of the drug release.
KW - Computer-Aided Design
KW - Delayed-Action Preparations
KW - Drug Compounding
KW - Drug Design
KW - Drug Liberation
KW - Hypromellose Derivatives
KW - Indomethacin/administration & dosage
KW - Polyesters/chemistry
KW - Polyethylene Glycols/chemistry
KW - Printing, Three-Dimensional
KW - Solubility
KW - Tablets
U2 - 10.1208/s12249-019-1341-z
DO - 10.1208/s12249-019-1341-z
M3 - Journal article
C2 - 30809745
VL - 20
JO - AAPS PharmSciTech
JF - AAPS PharmSciTech
SN - 1530-9932
IS - 3
M1 - 127
ER -
ID: 225663585