The role of configurational entropy in amorphous systems
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The role of configurational entropy in amorphous systems. / Graeser, Kirsten A.; Patterson, James E.; Zeitler, J. Axel; Rades, Thomas.
In: Pharmaceutics, Vol. 2, No. 2, 06.2010, p. 224-244.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The role of configurational entropy in amorphous systems
AU - Graeser, Kirsten A.
AU - Patterson, James E.
AU - Zeitler, J. Axel
AU - Rades, Thomas
PY - 2010/6
Y1 - 2010/6
N2 - Configurational entropy is an important parameter in amorphous systems. It is involved in the thermodynamic considerations, plays an important role in the molecular mobility calculations through its appearance in the Adam-Gibbs equation and provides information on the solubility increase of an amorphous form compared to its crystalline counterpart. This paper presents a calorimetric method which enables the scientist to quickly determine the values for the configurational entropy at any temperature and obtain the maximum of information from these measurements.
AB - Configurational entropy is an important parameter in amorphous systems. It is involved in the thermodynamic considerations, plays an important role in the molecular mobility calculations through its appearance in the Adam-Gibbs equation and provides information on the solubility increase of an amorphous form compared to its crystalline counterpart. This paper presents a calorimetric method which enables the scientist to quickly determine the values for the configurational entropy at any temperature and obtain the maximum of information from these measurements.
KW - Amorphous
KW - Configurational entropy
KW - Molecular mobility
KW - Solubility
UR - http://www.scopus.com/inward/record.url?scp=79952165879&partnerID=8YFLogxK
U2 - 10.3390/pharmaceutics2020224
DO - 10.3390/pharmaceutics2020224
M3 - Journal article
AN - SCOPUS:79952165879
VL - 2
SP - 224
EP - 244
JO - Pharmaceutics
JF - Pharmaceutics
SN - 1999-4923
IS - 2
ER -
ID: 299416701