The influence of co-formers on the dissolution rates of co-amorphous sulfamerazine/excipient systems

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The influence of co-formers on the dissolution rates of co-amorphous sulfamerazine/excipient systems. / Gniado, Katarzyna; Löbmann, Korbinian; Rades, Thomas; Erxleben, Andrea.

In: International Journal of Pharmaceutics, Vol. 504, No. 1-2, 17.05.2016, p. 20-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gniado, K, Löbmann, K, Rades, T & Erxleben, A 2016, 'The influence of co-formers on the dissolution rates of co-amorphous sulfamerazine/excipient systems', International Journal of Pharmaceutics, vol. 504, no. 1-2, pp. 20-6. https://doi.org/10.1016/j.ijpharm.2016.03.023

APA

Gniado, K., Löbmann, K., Rades, T., & Erxleben, A. (2016). The influence of co-formers on the dissolution rates of co-amorphous sulfamerazine/excipient systems. International Journal of Pharmaceutics, 504(1-2), 20-6. https://doi.org/10.1016/j.ijpharm.2016.03.023

Vancouver

Gniado K, Löbmann K, Rades T, Erxleben A. The influence of co-formers on the dissolution rates of co-amorphous sulfamerazine/excipient systems. International Journal of Pharmaceutics. 2016 May 17;504(1-2):20-6. https://doi.org/10.1016/j.ijpharm.2016.03.023

Author

Gniado, Katarzyna ; Löbmann, Korbinian ; Rades, Thomas ; Erxleben, Andrea. / The influence of co-formers on the dissolution rates of co-amorphous sulfamerazine/excipient systems. In: International Journal of Pharmaceutics. 2016 ; Vol. 504, No. 1-2. pp. 20-6.

Bibtex

@article{13957281ea8c43e193e5a747cfbc2aaa,
title = "The influence of co-formers on the dissolution rates of co-amorphous sulfamerazine/excipient systems",
abstract = "A comprehensive study on the dissolution properties of three co-amorphous sulfamerazine/excipient systems, namely sulfamerazine/deoxycholic acid, sulfamerazine/citric acid and sulfamerazine/sodium taurocholate (SMZ/DA, SMZ/CA and SMZ/NaTC; 1:1 molar ratio), is reported. While all three co-formers stabilize the amorphous state during storage, only co-amorphization with NaTC provides a dissolution advantage over crystalline SMZ and the reasons for this were analyzed. In the case of SMZ/DA extensive gelation of DA protects the amorphous phase from crystallization upon contact with buffer, but at the same time prevents the release of SMZ into solution. Disk dissolution studies showed an improved dissolution behavior of SMZ/CA compared to crystalline SMZ. However, enhanced dissolution properties were not seen in powder dissolution testing due to poor dispersibility. Co-amorphization of SMZ and NaTC resulted in a significant increase in dissolution rate, both in powder and disk dissolution studies.",
keywords = "Journal Article, Research Support, Non-U.S. Gov't",
author = "Katarzyna Gniado and Korbinian L{\"o}bmann and Thomas Rades and Andrea Erxleben",
note = "Copyright {\textcopyright} 2016. Published by Elsevier B.V.",
year = "2016",
month = may,
day = "17",
doi = "10.1016/j.ijpharm.2016.03.023",
language = "English",
volume = "504",
pages = "20--6",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - The influence of co-formers on the dissolution rates of co-amorphous sulfamerazine/excipient systems

AU - Gniado, Katarzyna

AU - Löbmann, Korbinian

AU - Rades, Thomas

AU - Erxleben, Andrea

N1 - Copyright © 2016. Published by Elsevier B.V.

PY - 2016/5/17

Y1 - 2016/5/17

N2 - A comprehensive study on the dissolution properties of three co-amorphous sulfamerazine/excipient systems, namely sulfamerazine/deoxycholic acid, sulfamerazine/citric acid and sulfamerazine/sodium taurocholate (SMZ/DA, SMZ/CA and SMZ/NaTC; 1:1 molar ratio), is reported. While all three co-formers stabilize the amorphous state during storage, only co-amorphization with NaTC provides a dissolution advantage over crystalline SMZ and the reasons for this were analyzed. In the case of SMZ/DA extensive gelation of DA protects the amorphous phase from crystallization upon contact with buffer, but at the same time prevents the release of SMZ into solution. Disk dissolution studies showed an improved dissolution behavior of SMZ/CA compared to crystalline SMZ. However, enhanced dissolution properties were not seen in powder dissolution testing due to poor dispersibility. Co-amorphization of SMZ and NaTC resulted in a significant increase in dissolution rate, both in powder and disk dissolution studies.

AB - A comprehensive study on the dissolution properties of three co-amorphous sulfamerazine/excipient systems, namely sulfamerazine/deoxycholic acid, sulfamerazine/citric acid and sulfamerazine/sodium taurocholate (SMZ/DA, SMZ/CA and SMZ/NaTC; 1:1 molar ratio), is reported. While all three co-formers stabilize the amorphous state during storage, only co-amorphization with NaTC provides a dissolution advantage over crystalline SMZ and the reasons for this were analyzed. In the case of SMZ/DA extensive gelation of DA protects the amorphous phase from crystallization upon contact with buffer, but at the same time prevents the release of SMZ into solution. Disk dissolution studies showed an improved dissolution behavior of SMZ/CA compared to crystalline SMZ. However, enhanced dissolution properties were not seen in powder dissolution testing due to poor dispersibility. Co-amorphization of SMZ and NaTC resulted in a significant increase in dissolution rate, both in powder and disk dissolution studies.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.ijpharm.2016.03.023

DO - 10.1016/j.ijpharm.2016.03.023

M3 - Journal article

C2 - 26992818

VL - 504

SP - 20

EP - 26

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 169382865