The Future of Pharmaceutical Manufacturing Sciences

Research output: Contribution to journalJournal articleResearchpeer-review

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The Future of Pharmaceutical Manufacturing Sciences. / Rantanen, Jukka; Khinast, Johannes.

In: Journal of Pharmaceutical Sciences, Vol. 104, No. 11, 11.2015, p. 3612-38.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Rantanen, J & Khinast, J 2015, 'The Future of Pharmaceutical Manufacturing Sciences', Journal of Pharmaceutical Sciences, vol. 104, no. 11, pp. 3612-38. https://doi.org/10.1002/jps.24594

APA

Rantanen, J., & Khinast, J. (2015). The Future of Pharmaceutical Manufacturing Sciences. Journal of Pharmaceutical Sciences, 104(11), 3612-38. https://doi.org/10.1002/jps.24594

Vancouver

Rantanen J, Khinast J. The Future of Pharmaceutical Manufacturing Sciences. Journal of Pharmaceutical Sciences. 2015 Nov;104(11):3612-38. https://doi.org/10.1002/jps.24594

Author

Rantanen, Jukka ; Khinast, Johannes. / The Future of Pharmaceutical Manufacturing Sciences. In: Journal of Pharmaceutical Sciences. 2015 ; Vol. 104, No. 11. pp. 3612-38.

Bibtex

@article{f23573ec34ba4b1aa1587aebd30db20b,
title = "The Future of Pharmaceutical Manufacturing Sciences",
abstract = "The entire pharmaceutical sector is in an urgent need of both innovative technological solutions and fundamental scientific work, enabling the production of highly engineered drug products. Commercial-scale manufacturing of complex drug delivery systems (DDSs) using the existing technologies is challenging. This review covers important elements of manufacturing sciences, beginning with risk management strategies and design of experiments (DoE) techniques. Experimental techniques should, where possible, be supported by computational approaches. With that regard, state-of-art mechanistic process modeling techniques are described in detail. Implementation of materials science tools paves the way to molecular-based processing of future DDSs. A snapshot of some of the existing tools is presented. Additionally, general engineering principles are discussed covering process measurement and process control solutions. Last part of the review addresses future manufacturing solutions, covering continuous processing and, specifically, hot-melt processing and printing-based technologies. Finally, challenges related to implementing these technologies as a part of future health care systems are discussed.",
author = "Jukka Rantanen and Johannes Khinast",
note = "{\circledC} 2015 The Authors. Journal of Pharmaceutical Sciences published by Wiley Periodicals, Inc. and the American Pharmacists Association.",
year = "2015",
month = "11",
doi = "10.1002/jps.24594",
language = "English",
volume = "104",
pages = "3612--38",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "11",

}

RIS

TY - JOUR

T1 - The Future of Pharmaceutical Manufacturing Sciences

AU - Rantanen, Jukka

AU - Khinast, Johannes

N1 - © 2015 The Authors. Journal of Pharmaceutical Sciences published by Wiley Periodicals, Inc. and the American Pharmacists Association.

PY - 2015/11

Y1 - 2015/11

N2 - The entire pharmaceutical sector is in an urgent need of both innovative technological solutions and fundamental scientific work, enabling the production of highly engineered drug products. Commercial-scale manufacturing of complex drug delivery systems (DDSs) using the existing technologies is challenging. This review covers important elements of manufacturing sciences, beginning with risk management strategies and design of experiments (DoE) techniques. Experimental techniques should, where possible, be supported by computational approaches. With that regard, state-of-art mechanistic process modeling techniques are described in detail. Implementation of materials science tools paves the way to molecular-based processing of future DDSs. A snapshot of some of the existing tools is presented. Additionally, general engineering principles are discussed covering process measurement and process control solutions. Last part of the review addresses future manufacturing solutions, covering continuous processing and, specifically, hot-melt processing and printing-based technologies. Finally, challenges related to implementing these technologies as a part of future health care systems are discussed.

AB - The entire pharmaceutical sector is in an urgent need of both innovative technological solutions and fundamental scientific work, enabling the production of highly engineered drug products. Commercial-scale manufacturing of complex drug delivery systems (DDSs) using the existing technologies is challenging. This review covers important elements of manufacturing sciences, beginning with risk management strategies and design of experiments (DoE) techniques. Experimental techniques should, where possible, be supported by computational approaches. With that regard, state-of-art mechanistic process modeling techniques are described in detail. Implementation of materials science tools paves the way to molecular-based processing of future DDSs. A snapshot of some of the existing tools is presented. Additionally, general engineering principles are discussed covering process measurement and process control solutions. Last part of the review addresses future manufacturing solutions, covering continuous processing and, specifically, hot-melt processing and printing-based technologies. Finally, challenges related to implementing these technologies as a part of future health care systems are discussed.

U2 - 10.1002/jps.24594

DO - 10.1002/jps.24594

M3 - Journal article

C2 - 26280993

VL - 104

SP - 3612

EP - 3638

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 11

ER -

ID: 161622811