Terahertz pulsed spectroscopy and imaging in the pharmaceutical setting--a review
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Terahertz pulsed spectroscopy and imaging in the pharmaceutical setting--a review. / Zeitler, J Axel; Taday, Philip F; Newnham, David A; Pepper, Michael; Gordon, Keith C; Rades, Thomas.
In: Journal of Pharmacy and Pharmacology, Vol. 59, No. 2, 2007, p. 209-23.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Terahertz pulsed spectroscopy and imaging in the pharmaceutical setting--a review
AU - Zeitler, J Axel
AU - Taday, Philip F
AU - Newnham, David A
AU - Pepper, Michael
AU - Gordon, Keith C
AU - Rades, Thomas
PY - 2007
Y1 - 2007
N2 - Terahertz pulsed spectroscopy (TPS) and terahertz pulsed imaging (TPI) are two novel techniques for the physical characterization of pharmaceutical drug materials and final solid dosage forms, utilizing spectral information in the far infrared region of the electromagnetic spectrum. This review focuses on the development and performance of pharmaceutical applications of terahertz technology compared with other tools for physical characterization. TPS can be used to characterize crystalline properties of drugs and excipients. Different polymorphic forms of a drug can be readily distinguished and quantified. Recent developments towards a better understanding of the fundamental theory behind spectroscopy in the far infrared have been discussed. Applications for TPI include the measurement of coating thickness and uniformity in coated pharmaceutical tablets, structural imaging and 3D chemical imaging of solid dosage forms.
AB - Terahertz pulsed spectroscopy (TPS) and terahertz pulsed imaging (TPI) are two novel techniques for the physical characterization of pharmaceutical drug materials and final solid dosage forms, utilizing spectral information in the far infrared region of the electromagnetic spectrum. This review focuses on the development and performance of pharmaceutical applications of terahertz technology compared with other tools for physical characterization. TPS can be used to characterize crystalline properties of drugs and excipients. Different polymorphic forms of a drug can be readily distinguished and quantified. Recent developments towards a better understanding of the fundamental theory behind spectroscopy in the far infrared have been discussed. Applications for TPI include the measurement of coating thickness and uniformity in coated pharmaceutical tablets, structural imaging and 3D chemical imaging of solid dosage forms.
U2 - 10.1211/jpp.59.2.0008
DO - 10.1211/jpp.59.2.0008
M3 - Journal article
C2 - 17270075
VL - 59
SP - 209
EP - 223
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
SN - 0022-3573
IS - 2
ER -
ID: 40357086