Terahertz pulsed imaging as an advanced characterisation tool for film coatings--a review

Research output: Contribution to journalJournal articlepeer-review

Standard

Terahertz pulsed imaging as an advanced characterisation tool for film coatings--a review. / Haaser, Miriam; Gordon, Keith C; Strachan, Clare J; Rades, Thomas.

In: International Journal of Pharmaceutics, Vol. 457, No. 2, 05.12.2013, p. 510-20.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Haaser, M, Gordon, KC, Strachan, CJ & Rades, T 2013, 'Terahertz pulsed imaging as an advanced characterisation tool for film coatings--a review', International Journal of Pharmaceutics, vol. 457, no. 2, pp. 510-20. https://doi.org/10.1016/j.ijpharm.2013.03.053

APA

Haaser, M., Gordon, K. C., Strachan, C. J., & Rades, T. (2013). Terahertz pulsed imaging as an advanced characterisation tool for film coatings--a review. International Journal of Pharmaceutics, 457(2), 510-20. https://doi.org/10.1016/j.ijpharm.2013.03.053

Vancouver

Haaser M, Gordon KC, Strachan CJ, Rades T. Terahertz pulsed imaging as an advanced characterisation tool for film coatings--a review. International Journal of Pharmaceutics. 2013 Dec 5;457(2):510-20. https://doi.org/10.1016/j.ijpharm.2013.03.053

Author

Haaser, Miriam ; Gordon, Keith C ; Strachan, Clare J ; Rades, Thomas. / Terahertz pulsed imaging as an advanced characterisation tool for film coatings--a review. In: International Journal of Pharmaceutics. 2013 ; Vol. 457, No. 2. pp. 510-20.

Bibtex

@article{20e3c5cbb6084d52a164e618db3ce72b,
title = "Terahertz pulsed imaging as an advanced characterisation tool for film coatings--a review",
abstract = "Solid dosage forms are the pharmaceutical drug delivery systems of choice for oral drug delivery. These solid dosage forms are often coated to modify the physico-chemical properties of the active pharmaceutical ingredients (APIs), in particular to alter release kinetics. Since the product performance of coated dosage forms is a function of their critical coating attributes, including coating thickness, uniformity, and density, more advanced quality control techniques than weight gain are required. A recently introduced non-destructive method to quantitatively characterise coating quality is terahertz pulsed imaging (TPI). The ability of terahertz radiation to penetrate many pharmaceutical materials enables structural features of coated solid dosage forms to be probed at depth, which is not readily achievable with other established imaging techniques, e.g. near-infrared (NIR) and Raman spectroscopy. In this review TPI is introduced and various applications of the technique in pharmaceutical coating analysis are discussed. These include evaluation of coating thickness, uniformity, surface morphology, density, defects and buried structures as well as correlation between TPI measurements and drug release performance, coating process monitoring and scale up. Furthermore, challenges and limitations of the technique are discussed.",
author = "Miriam Haaser and Gordon, {Keith C} and Strachan, {Clare J} and Thomas Rades",
note = "Copyright {\textcopyright} 2013 Elsevier B.V. All rights reserved.",
year = "2013",
month = dec,
day = "5",
doi = "10.1016/j.ijpharm.2013.03.053",
language = "English",
volume = "457",
pages = "510--20",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Terahertz pulsed imaging as an advanced characterisation tool for film coatings--a review

AU - Haaser, Miriam

AU - Gordon, Keith C

AU - Strachan, Clare J

AU - Rades, Thomas

N1 - Copyright © 2013 Elsevier B.V. All rights reserved.

PY - 2013/12/5

Y1 - 2013/12/5

N2 - Solid dosage forms are the pharmaceutical drug delivery systems of choice for oral drug delivery. These solid dosage forms are often coated to modify the physico-chemical properties of the active pharmaceutical ingredients (APIs), in particular to alter release kinetics. Since the product performance of coated dosage forms is a function of their critical coating attributes, including coating thickness, uniformity, and density, more advanced quality control techniques than weight gain are required. A recently introduced non-destructive method to quantitatively characterise coating quality is terahertz pulsed imaging (TPI). The ability of terahertz radiation to penetrate many pharmaceutical materials enables structural features of coated solid dosage forms to be probed at depth, which is not readily achievable with other established imaging techniques, e.g. near-infrared (NIR) and Raman spectroscopy. In this review TPI is introduced and various applications of the technique in pharmaceutical coating analysis are discussed. These include evaluation of coating thickness, uniformity, surface morphology, density, defects and buried structures as well as correlation between TPI measurements and drug release performance, coating process monitoring and scale up. Furthermore, challenges and limitations of the technique are discussed.

AB - Solid dosage forms are the pharmaceutical drug delivery systems of choice for oral drug delivery. These solid dosage forms are often coated to modify the physico-chemical properties of the active pharmaceutical ingredients (APIs), in particular to alter release kinetics. Since the product performance of coated dosage forms is a function of their critical coating attributes, including coating thickness, uniformity, and density, more advanced quality control techniques than weight gain are required. A recently introduced non-destructive method to quantitatively characterise coating quality is terahertz pulsed imaging (TPI). The ability of terahertz radiation to penetrate many pharmaceutical materials enables structural features of coated solid dosage forms to be probed at depth, which is not readily achievable with other established imaging techniques, e.g. near-infrared (NIR) and Raman spectroscopy. In this review TPI is introduced and various applications of the technique in pharmaceutical coating analysis are discussed. These include evaluation of coating thickness, uniformity, surface morphology, density, defects and buried structures as well as correlation between TPI measurements and drug release performance, coating process monitoring and scale up. Furthermore, challenges and limitations of the technique are discussed.

U2 - 10.1016/j.ijpharm.2013.03.053

DO - 10.1016/j.ijpharm.2013.03.053

M3 - Journal article

C2 - 23570960

VL - 457

SP - 510

EP - 520

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 2

ER -

ID: 104834919