Tailored beads made of dissolved cellulose - Investigation of their drug release properties

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Tailored beads made of dissolved cellulose - Investigation of their drug release properties. / Yildir, Emrah; Kolakovic, Ruzica; Genina, Natalja; Trygg, Jani; Gericke, Martin; Hanski, Leena; Ehlers, Henrik; Rantanen, Jukka; Tenho, Mikko; Vuorela, Pia; Fardim, Pedro; Sandler, Niklas.

In: International Journal of Pharmaceutics, Vol. 456, No. 2, 2013, p. 417-423.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Yildir, E, Kolakovic, R, Genina, N, Trygg, J, Gericke, M, Hanski, L, Ehlers, H, Rantanen, J, Tenho, M, Vuorela, P, Fardim, P & Sandler, N 2013, 'Tailored beads made of dissolved cellulose - Investigation of their drug release properties', International Journal of Pharmaceutics, vol. 456, no. 2, pp. 417-423. https://doi.org/10.1016/j.ijpharm.2013.08.047

APA

Yildir, E., Kolakovic, R., Genina, N., Trygg, J., Gericke, M., Hanski, L., Ehlers, H., Rantanen, J., Tenho, M., Vuorela, P., Fardim, P., & Sandler, N. (2013). Tailored beads made of dissolved cellulose - Investigation of their drug release properties. International Journal of Pharmaceutics, 456(2), 417-423. https://doi.org/10.1016/j.ijpharm.2013.08.047

Vancouver

Yildir E, Kolakovic R, Genina N, Trygg J, Gericke M, Hanski L et al. Tailored beads made of dissolved cellulose - Investigation of their drug release properties. International Journal of Pharmaceutics. 2013;456(2):417-423. https://doi.org/10.1016/j.ijpharm.2013.08.047

Author

Yildir, Emrah ; Kolakovic, Ruzica ; Genina, Natalja ; Trygg, Jani ; Gericke, Martin ; Hanski, Leena ; Ehlers, Henrik ; Rantanen, Jukka ; Tenho, Mikko ; Vuorela, Pia ; Fardim, Pedro ; Sandler, Niklas. / Tailored beads made of dissolved cellulose - Investigation of their drug release properties. In: International Journal of Pharmaceutics. 2013 ; Vol. 456, No. 2. pp. 417-423.

Bibtex

@article{8a1f0226138443839dd7c4dc9c2f8ef3,
title = "Tailored beads made of dissolved cellulose - Investigation of their drug release properties",
abstract = "In the frame of this work, we have investigated drug entrapping and release abilities of new type of porous cellulose beads (CBs) as a spherical matrix system for drug delivery. For that purpose, CBs prepared with three different methods were used as drug carriers and three compounds, anhydrous theophylline (Thp), riboflavin 5′-phosphate sodium (RSP) and lidocaine hydrochloride monohydrate (LiHCl) were used as model drug substances. The loading procedure was carried out by immersing swollen empty beads into the solutions of different concentrations of model drugs. The morphology of empty and loaded beads was examined using a field emission scanning electron microscopy (FE-SEM). Near-infrared (NIR) imaging was performed to identify the drug distributions on and within the loaded CBs. The drug amount incorporated into CBs was examined spectrophotometrically and in vitro drug release studies were performed to determine the drug release rates. The results of FE-SEM and chemical NIR imaging analyses revealed that incorporated drug were distributed on the surface and but also within the internal structure of the CBs. Physical properties of CBs and solubility of model drugs had effect on loading efficacy. Also, the drug release rates were controlled by solubility of model drugs (diffusion controlled release). In conclusion, CBs from dissolved cellulose show promise in achieving controlled drug delivery. {\textcopyright} 2013 Elsevier B.V. All rights reserved.",
keywords = "Chemical imaging, Drug delivery, Drug loading, Macrospheres, Porous cellulose beads",
author = "Emrah Yildir and Ruzica Kolakovic and Natalja Genina and Jani Trygg and Martin Gericke and Leena Hanski and Henrik Ehlers and Jukka Rantanen and Mikko Tenho and Pia Vuorela and Pedro Fardim and Niklas Sandler",
year = "2013",
doi = "10.1016/j.ijpharm.2013.08.047",
language = "English",
volume = "456",
pages = "417--423",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Tailored beads made of dissolved cellulose - Investigation of their drug release properties

AU - Yildir, Emrah

AU - Kolakovic, Ruzica

AU - Genina, Natalja

AU - Trygg, Jani

AU - Gericke, Martin

AU - Hanski, Leena

AU - Ehlers, Henrik

AU - Rantanen, Jukka

AU - Tenho, Mikko

AU - Vuorela, Pia

AU - Fardim, Pedro

AU - Sandler, Niklas

PY - 2013

Y1 - 2013

N2 - In the frame of this work, we have investigated drug entrapping and release abilities of new type of porous cellulose beads (CBs) as a spherical matrix system for drug delivery. For that purpose, CBs prepared with three different methods were used as drug carriers and three compounds, anhydrous theophylline (Thp), riboflavin 5′-phosphate sodium (RSP) and lidocaine hydrochloride monohydrate (LiHCl) were used as model drug substances. The loading procedure was carried out by immersing swollen empty beads into the solutions of different concentrations of model drugs. The morphology of empty and loaded beads was examined using a field emission scanning electron microscopy (FE-SEM). Near-infrared (NIR) imaging was performed to identify the drug distributions on and within the loaded CBs. The drug amount incorporated into CBs was examined spectrophotometrically and in vitro drug release studies were performed to determine the drug release rates. The results of FE-SEM and chemical NIR imaging analyses revealed that incorporated drug were distributed on the surface and but also within the internal structure of the CBs. Physical properties of CBs and solubility of model drugs had effect on loading efficacy. Also, the drug release rates were controlled by solubility of model drugs (diffusion controlled release). In conclusion, CBs from dissolved cellulose show promise in achieving controlled drug delivery. © 2013 Elsevier B.V. All rights reserved.

AB - In the frame of this work, we have investigated drug entrapping and release abilities of new type of porous cellulose beads (CBs) as a spherical matrix system for drug delivery. For that purpose, CBs prepared with three different methods were used as drug carriers and three compounds, anhydrous theophylline (Thp), riboflavin 5′-phosphate sodium (RSP) and lidocaine hydrochloride monohydrate (LiHCl) were used as model drug substances. The loading procedure was carried out by immersing swollen empty beads into the solutions of different concentrations of model drugs. The morphology of empty and loaded beads was examined using a field emission scanning electron microscopy (FE-SEM). Near-infrared (NIR) imaging was performed to identify the drug distributions on and within the loaded CBs. The drug amount incorporated into CBs was examined spectrophotometrically and in vitro drug release studies were performed to determine the drug release rates. The results of FE-SEM and chemical NIR imaging analyses revealed that incorporated drug were distributed on the surface and but also within the internal structure of the CBs. Physical properties of CBs and solubility of model drugs had effect on loading efficacy. Also, the drug release rates were controlled by solubility of model drugs (diffusion controlled release). In conclusion, CBs from dissolved cellulose show promise in achieving controlled drug delivery. © 2013 Elsevier B.V. All rights reserved.

KW - Chemical imaging

KW - Drug delivery

KW - Drug loading

KW - Macrospheres

KW - Porous cellulose beads

U2 - 10.1016/j.ijpharm.2013.08.047

DO - 10.1016/j.ijpharm.2013.08.047

M3 - Journal article

C2 - 24012866

VL - 456

SP - 417

EP - 423

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 2

ER -

ID: 145539399