Stability aspects of salmon calcitonin entrapped in poly(ether-ester) sustained release systems

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Stability aspects of salmon calcitonin entrapped in poly(ether-ester) sustained release systems. / van Dijkhuizen-Radersma, R; Nicolas, H M; van de Weert, Marco; Blom, M; de Groot, K; Bezemer, J M.

In: International Journal of Pharmaceutics, Vol. 248, No. 1-2, 06.11.2002, p. 229-37.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

van Dijkhuizen-Radersma, R, Nicolas, HM, van de Weert, M, Blom, M, de Groot, K & Bezemer, JM 2002, 'Stability aspects of salmon calcitonin entrapped in poly(ether-ester) sustained release systems', International Journal of Pharmaceutics, vol. 248, no. 1-2, pp. 229-37.

APA

van Dijkhuizen-Radersma, R., Nicolas, H. M., van de Weert, M., Blom, M., de Groot, K., & Bezemer, J. M. (2002). Stability aspects of salmon calcitonin entrapped in poly(ether-ester) sustained release systems. International Journal of Pharmaceutics, 248(1-2), 229-37.

Vancouver

van Dijkhuizen-Radersma R, Nicolas HM, van de Weert M, Blom M, de Groot K, Bezemer JM. Stability aspects of salmon calcitonin entrapped in poly(ether-ester) sustained release systems. International Journal of Pharmaceutics. 2002 Nov 6;248(1-2):229-37.

Author

van Dijkhuizen-Radersma, R ; Nicolas, H M ; van de Weert, Marco ; Blom, M ; de Groot, K ; Bezemer, J M. / Stability aspects of salmon calcitonin entrapped in poly(ether-ester) sustained release systems. In: International Journal of Pharmaceutics. 2002 ; Vol. 248, No. 1-2. pp. 229-37.

Bibtex

@article{4ed5e21106474f308a68577888e5a42e,
title = "Stability aspects of salmon calcitonin entrapped in poly(ether-ester) sustained release systems",
abstract = "Poly(ether-ester)s composed of hydrophilic poly(ethylene glycol)-terephthalate (PEGT) blocks and hydrophobic poly(butylene terephthalate) (PBT) blocks were studied as matrix for the controlled release of calcitonin. Salmon calcitonin loaded PEGT/PBT films were prepared from water-in-oil emulsions. The initial calcitonin release rate could be tailored by the copolymer composition, but incomplete release of calcitonin was observed. FTIR measurements indicated aggregation of calcitonin in the matrix, which was not due to the preparation method of the matrices, but due to the instability of calcitonin in an aqueous environment. Release experiments showed the susceptibility of calcitonin towards the composition of the release medium, in particular to the presence of metal ions. With increasing amount of sodium ions, a decrease in the total amount of released calcitonin was observed due to enhanced aggregation. The calcitonin had to be stabilized in the matrix to prevent aggregation. Incorporation of sodium dodecyl sulphate (SDS) as a stabilizer in PEGT/PBT matrices increased the percentage of calcitonin released, but could not avoid aggregation on a longer term.",
author = "{van Dijkhuizen-Radersma}, R and Nicolas, {H M} and {van de Weert}, Marco and M Blom and {de Groot}, K and Bezemer, {J M}",
year = "2002",
month = "11",
day = "6",
language = "English",
volume = "248",
pages = "229--37",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Stability aspects of salmon calcitonin entrapped in poly(ether-ester) sustained release systems

AU - van Dijkhuizen-Radersma, R

AU - Nicolas, H M

AU - van de Weert, Marco

AU - Blom, M

AU - de Groot, K

AU - Bezemer, J M

PY - 2002/11/6

Y1 - 2002/11/6

N2 - Poly(ether-ester)s composed of hydrophilic poly(ethylene glycol)-terephthalate (PEGT) blocks and hydrophobic poly(butylene terephthalate) (PBT) blocks were studied as matrix for the controlled release of calcitonin. Salmon calcitonin loaded PEGT/PBT films were prepared from water-in-oil emulsions. The initial calcitonin release rate could be tailored by the copolymer composition, but incomplete release of calcitonin was observed. FTIR measurements indicated aggregation of calcitonin in the matrix, which was not due to the preparation method of the matrices, but due to the instability of calcitonin in an aqueous environment. Release experiments showed the susceptibility of calcitonin towards the composition of the release medium, in particular to the presence of metal ions. With increasing amount of sodium ions, a decrease in the total amount of released calcitonin was observed due to enhanced aggregation. The calcitonin had to be stabilized in the matrix to prevent aggregation. Incorporation of sodium dodecyl sulphate (SDS) as a stabilizer in PEGT/PBT matrices increased the percentage of calcitonin released, but could not avoid aggregation on a longer term.

AB - Poly(ether-ester)s composed of hydrophilic poly(ethylene glycol)-terephthalate (PEGT) blocks and hydrophobic poly(butylene terephthalate) (PBT) blocks were studied as matrix for the controlled release of calcitonin. Salmon calcitonin loaded PEGT/PBT films were prepared from water-in-oil emulsions. The initial calcitonin release rate could be tailored by the copolymer composition, but incomplete release of calcitonin was observed. FTIR measurements indicated aggregation of calcitonin in the matrix, which was not due to the preparation method of the matrices, but due to the instability of calcitonin in an aqueous environment. Release experiments showed the susceptibility of calcitonin towards the composition of the release medium, in particular to the presence of metal ions. With increasing amount of sodium ions, a decrease in the total amount of released calcitonin was observed due to enhanced aggregation. The calcitonin had to be stabilized in the matrix to prevent aggregation. Incorporation of sodium dodecyl sulphate (SDS) as a stabilizer in PEGT/PBT matrices increased the percentage of calcitonin released, but could not avoid aggregation on a longer term.

M3 - Journal article

C2 - 12429476

VL - 248

SP - 229

EP - 237

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 44640734