Routes for drug translocation across the blood-brain barrier: Exploiting peptides as delivery vectors

Research output: Contribution to journal › Review › Research › peer-review

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Routes for drug translocation across the blood-brain barrier : Exploiting peptides as delivery vectors. / Kristensen, Mie; Brodin, Birger.

In: Journal of Pharmaceutical Sciences, Vol. 106, No. 9, 09.2017, p. 2326-2334.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Kristensen, M & Brodin, B 2017, 'Routes for drug translocation across the blood-brain barrier: Exploiting peptides as delivery vectors', Journal of Pharmaceutical Sciences, vol. 106, no. 9, pp. 2326-2334. https://doi.org/10.1016/j.xphs.2017.04.080

APA

Kristensen, M., & Brodin, B. (2017). Routes for drug translocation across the blood-brain barrier: Exploiting peptides as delivery vectors. Journal of Pharmaceutical Sciences, 106(9), 2326-2334. https://doi.org/10.1016/j.xphs.2017.04.080

Vancouver

Kristensen M, Brodin B. Routes for drug translocation across the blood-brain barrier: Exploiting peptides as delivery vectors. Journal of Pharmaceutical Sciences. 2017 Sep;106(9):2326-2334. https://doi.org/10.1016/j.xphs.2017.04.080

Author

Kristensen, Mie ; Brodin, Birger. / Routes for drug translocation across the blood-brain barrier : Exploiting peptides as delivery vectors. In: Journal of Pharmaceutical Sciences. 2017 ; Vol. 106, No. 9. pp. 2326-2334.

Bibtex

@article{5a25ee697c6b481aaa08c7164aeac08f,
title = "Routes for drug translocation across the blood-brain barrier: Exploiting peptides as delivery vectors",
abstract = "A number of potent drugs for the treatment of brain diseases are available. However, in order for them to reach their target site of action, they must pass the blood-brain barrier (BBB). The capillary endothelium comprises the major barrier of the BBB and allows only passive permeation of some small lipophilic molecules. Brain delivery of the larger biopharmaceuticals, which today includes an increasing number of novel drug entities, is therefore restricted; both due to their molecular size and their hydrophilic nature. Thus, the development of novel drug entities intended for the treatment of brain diseases such as neurodegenerative diseases or brain cancers, require a delivery strategy for overcoming the BBB before reaching its final target within the brain. Peptide-based delivery vectors is an emerging tool as shuttles for drug delivery across the BBB and one may explore receptor-mediated transcytosis, adsorptive-mediated transcytosis, and the paracellular route. The latter, however, being controversial due to the risk of co-delivery of blood-borne potential harmful substances. On the other hand a number of studies report on drug delivery across the BBB exploiting receptor-mediated transcytosis and adsorptive-mediated transcytosis, indicating that peptides and peptide vectors may be of use in a central nervous system (CNS) delivery context.",
keywords = "Journal Article, Review",
author = "Mie Kristensen and Birger Brodin",
note = "Copyright {\textcopyright} 2017. Published by Elsevier Inc.",
year = "2017",
month = sep,
doi = "10.1016/j.xphs.2017.04.080",
language = "English",
volume = "106",
pages = "2326--2334",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "9",

}

RIS

TY - JOUR

T1 - Routes for drug translocation across the blood-brain barrier

T2 - Exploiting peptides as delivery vectors

AU - Kristensen, Mie

AU - Brodin, Birger

N1 - Copyright © 2017. Published by Elsevier Inc.

PY - 2017/9

Y1 - 2017/9

N2 - A number of potent drugs for the treatment of brain diseases are available. However, in order for them to reach their target site of action, they must pass the blood-brain barrier (BBB). The capillary endothelium comprises the major barrier of the BBB and allows only passive permeation of some small lipophilic molecules. Brain delivery of the larger biopharmaceuticals, which today includes an increasing number of novel drug entities, is therefore restricted; both due to their molecular size and their hydrophilic nature. Thus, the development of novel drug entities intended for the treatment of brain diseases such as neurodegenerative diseases or brain cancers, require a delivery strategy for overcoming the BBB before reaching its final target within the brain. Peptide-based delivery vectors is an emerging tool as shuttles for drug delivery across the BBB and one may explore receptor-mediated transcytosis, adsorptive-mediated transcytosis, and the paracellular route. The latter, however, being controversial due to the risk of co-delivery of blood-borne potential harmful substances. On the other hand a number of studies report on drug delivery across the BBB exploiting receptor-mediated transcytosis and adsorptive-mediated transcytosis, indicating that peptides and peptide vectors may be of use in a central nervous system (CNS) delivery context.

AB - A number of potent drugs for the treatment of brain diseases are available. However, in order for them to reach their target site of action, they must pass the blood-brain barrier (BBB). The capillary endothelium comprises the major barrier of the BBB and allows only passive permeation of some small lipophilic molecules. Brain delivery of the larger biopharmaceuticals, which today includes an increasing number of novel drug entities, is therefore restricted; both due to their molecular size and their hydrophilic nature. Thus, the development of novel drug entities intended for the treatment of brain diseases such as neurodegenerative diseases or brain cancers, require a delivery strategy for overcoming the BBB before reaching its final target within the brain. Peptide-based delivery vectors is an emerging tool as shuttles for drug delivery across the BBB and one may explore receptor-mediated transcytosis, adsorptive-mediated transcytosis, and the paracellular route. The latter, however, being controversial due to the risk of co-delivery of blood-borne potential harmful substances. On the other hand a number of studies report on drug delivery across the BBB exploiting receptor-mediated transcytosis and adsorptive-mediated transcytosis, indicating that peptides and peptide vectors may be of use in a central nervous system (CNS) delivery context.

KW - Journal Article

KW - Review

U2 - 10.1016/j.xphs.2017.04.080

DO - 10.1016/j.xphs.2017.04.080

M3 - Review

C2 - 28501469

VL - 106

SP - 2326

EP - 2334

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 9

ER -

ID: 180851026