Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development

Research output: Contribution to journal › Journal article › Research › peer-review

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Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development. / Knopp, Matthias Manne; Löbmann, Korbinian; Elder, David P.; Rades, Thomas; Holm, René.

In: European Journal of Pharmaceutical Sciences, Vol. 87, 01.05.2016, p. 164-173.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Knopp, MM, Löbmann, K, Elder, DP, Rades, T & Holm, R 2016, 'Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development', European Journal of Pharmaceutical Sciences, vol. 87, pp. 164-173. https://doi.org/10.1016/j.ejps.2015.12.024

APA

Knopp, M. M., Löbmann, K., Elder, D. P., Rades, T., & Holm, R. (2016). Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development. European Journal of Pharmaceutical Sciences, 87, 164-173. https://doi.org/10.1016/j.ejps.2015.12.024

Vancouver

Knopp MM, Löbmann K, Elder DP, Rades T, Holm R. Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development. European Journal of Pharmaceutical Sciences. 2016 May 1;87:164-173. https://doi.org/10.1016/j.ejps.2015.12.024

Author

Knopp, Matthias Manne ; Löbmann, Korbinian ; Elder, David P. ; Rades, Thomas ; Holm, René. / Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development. In: European Journal of Pharmaceutical Sciences. 2016 ; Vol. 87. pp. 164-173.

Bibtex

@article{856c101f1f0c41d79801c312fc1bb217,
title = "Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development",
abstract = "Differential scanning calorimetry (DSC) is frequently the thermal analysis technique of choice within preformulation and formulation sciences because of its ability to provide detailed information about both the physical and energetic properties of a substance and/or formulation. However, conventional DSC has shortcomings with respect to weak transitions and overlapping events, which could be solved by the use of the more sophisticated modulated DSC (mDSC). mDSC has multiple potential applications within the pharmaceutical field and the present review provides an up-to-date overview of these applications. It is aimed to serve as a broad introduction to newcomers, and also as a valuable reference for those already practising in the field. Complex mDSC was introduced more than two decades ago and has been an important tool for the quantification of amorphous materials and development of freeze-dried formulations. However, as discussed in the present review, a number of other potential applications could also be relevant for the pharmaceutical scientist.",
author = "Knopp, {Matthias Manne} and Korbinian L{\"o}bmann and Elder, {David P.} and Thomas Rades and Ren{\'e} Holm",
year = "2016",
month = may,
day = "1",
doi = "10.1016/j.ejps.2015.12.024",
language = "English",
volume = "87",
pages = "164--173",
journal = "Norvegica Pharmaceutica Acta",
issn = "0928-0987",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development

AU - Knopp, Matthias Manne

AU - Löbmann, Korbinian

AU - Elder, David P.

AU - Rades, Thomas

AU - Holm, René

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Differential scanning calorimetry (DSC) is frequently the thermal analysis technique of choice within preformulation and formulation sciences because of its ability to provide detailed information about both the physical and energetic properties of a substance and/or formulation. However, conventional DSC has shortcomings with respect to weak transitions and overlapping events, which could be solved by the use of the more sophisticated modulated DSC (mDSC). mDSC has multiple potential applications within the pharmaceutical field and the present review provides an up-to-date overview of these applications. It is aimed to serve as a broad introduction to newcomers, and also as a valuable reference for those already practising in the field. Complex mDSC was introduced more than two decades ago and has been an important tool for the quantification of amorphous materials and development of freeze-dried formulations. However, as discussed in the present review, a number of other potential applications could also be relevant for the pharmaceutical scientist.

AB - Differential scanning calorimetry (DSC) is frequently the thermal analysis technique of choice within preformulation and formulation sciences because of its ability to provide detailed information about both the physical and energetic properties of a substance and/or formulation. However, conventional DSC has shortcomings with respect to weak transitions and overlapping events, which could be solved by the use of the more sophisticated modulated DSC (mDSC). mDSC has multiple potential applications within the pharmaceutical field and the present review provides an up-to-date overview of these applications. It is aimed to serve as a broad introduction to newcomers, and also as a valuable reference for those already practising in the field. Complex mDSC was introduced more than two decades ago and has been an important tool for the quantification of amorphous materials and development of freeze-dried formulations. However, as discussed in the present review, a number of other potential applications could also be relevant for the pharmaceutical scientist.

U2 - 10.1016/j.ejps.2015.12.024

DO - 10.1016/j.ejps.2015.12.024

M3 - Journal article

C2 - 26721421

VL - 87

SP - 164

EP - 173

JO - Norvegica Pharmaceutica Acta

JF - Norvegica Pharmaceutica Acta

SN - 0928-0987

ER -

ID: 162186491