Rapid interferometric imaging of printed drug laden multilayer structures

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Rapid interferometric imaging of printed drug laden multilayer structures. / Sandler, Niklas; Kassamakov, Ivan; Ehlers, Henrik; Genina, Natalja; Ylitalo, Tuomo; Haeggstrom, Edward.

In: Scientific Reports, Vol. 4, 07.02.2014, p. 4020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sandler, N, Kassamakov, I, Ehlers, H, Genina, N, Ylitalo, T & Haeggstrom, E 2014, 'Rapid interferometric imaging of printed drug laden multilayer structures', Scientific Reports, vol. 4, pp. 4020. https://doi.org/10.1038/srep04020

APA

Sandler, N., Kassamakov, I., Ehlers, H., Genina, N., Ylitalo, T., & Haeggstrom, E. (2014). Rapid interferometric imaging of printed drug laden multilayer structures. Scientific Reports, 4, 4020. https://doi.org/10.1038/srep04020

Vancouver

Sandler N, Kassamakov I, Ehlers H, Genina N, Ylitalo T, Haeggstrom E. Rapid interferometric imaging of printed drug laden multilayer structures. Scientific Reports. 2014 Feb 7;4:4020. https://doi.org/10.1038/srep04020

Author

Sandler, Niklas ; Kassamakov, Ivan ; Ehlers, Henrik ; Genina, Natalja ; Ylitalo, Tuomo ; Haeggstrom, Edward. / Rapid interferometric imaging of printed drug laden multilayer structures. In: Scientific Reports. 2014 ; Vol. 4. pp. 4020.

Bibtex

@article{b93ea4708a7f4766a9cd8c4b1bda06a1,
title = "Rapid interferometric imaging of printed drug laden multilayer structures",
abstract = "The developments in printing technologies allow fabrication of micron-size nano-layered delivery systems to personal specifications. In this study we fabricated layered polymer structures for drug-delivery into a microfluidic channel and aimed to interferometrically assure their topography and adherence to each other. We present a scanning white light interferometer (SWLI) method for quantitative assurance of the topography of the embedded structure. We determined rapidly in non-destructive manner the thickness and roughness of the structures and whether the printed layers containing polymers or/and active pharmaceutical ingredients (API) adhere to each other. This is crucial in order to have predetermined drug release profiles. We also demonstrate non-invasive measurement of a polymer structure in a microfluidic channel. It shown that traceable interferometric 3D microscopy is a viable technique for detailed structural quality assurance of layered drug-delivery systems. The approach can have impact and find use in a much broader setting within and outside life sciences.",
keywords = "Drug Delivery Systems, Imaging, Three-Dimensional, Individualized Medicine, Individualized Medicine: methods, Interferometry, Interferometry: methods, Microfluidic Analytical Techniques, Microscopy, Interference, Nanostructures, Pharmaceutical Preparations, Pharmaceutical Preparations: chemical synthesis, Polymers, Polymers: chemistry, Printing, Surface Properties",
author = "Niklas Sandler and Ivan Kassamakov and Henrik Ehlers and Natalja Genina and Tuomo Ylitalo and Edward Haeggstrom",
year = "2014",
month = feb,
day = "7",
doi = "10.1038/srep04020",
language = "English",
volume = "4",
pages = "4020",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Rapid interferometric imaging of printed drug laden multilayer structures

AU - Sandler, Niklas

AU - Kassamakov, Ivan

AU - Ehlers, Henrik

AU - Genina, Natalja

AU - Ylitalo, Tuomo

AU - Haeggstrom, Edward

PY - 2014/2/7

Y1 - 2014/2/7

N2 - The developments in printing technologies allow fabrication of micron-size nano-layered delivery systems to personal specifications. In this study we fabricated layered polymer structures for drug-delivery into a microfluidic channel and aimed to interferometrically assure their topography and adherence to each other. We present a scanning white light interferometer (SWLI) method for quantitative assurance of the topography of the embedded structure. We determined rapidly in non-destructive manner the thickness and roughness of the structures and whether the printed layers containing polymers or/and active pharmaceutical ingredients (API) adhere to each other. This is crucial in order to have predetermined drug release profiles. We also demonstrate non-invasive measurement of a polymer structure in a microfluidic channel. It shown that traceable interferometric 3D microscopy is a viable technique for detailed structural quality assurance of layered drug-delivery systems. The approach can have impact and find use in a much broader setting within and outside life sciences.

AB - The developments in printing technologies allow fabrication of micron-size nano-layered delivery systems to personal specifications. In this study we fabricated layered polymer structures for drug-delivery into a microfluidic channel and aimed to interferometrically assure their topography and adherence to each other. We present a scanning white light interferometer (SWLI) method for quantitative assurance of the topography of the embedded structure. We determined rapidly in non-destructive manner the thickness and roughness of the structures and whether the printed layers containing polymers or/and active pharmaceutical ingredients (API) adhere to each other. This is crucial in order to have predetermined drug release profiles. We also demonstrate non-invasive measurement of a polymer structure in a microfluidic channel. It shown that traceable interferometric 3D microscopy is a viable technique for detailed structural quality assurance of layered drug-delivery systems. The approach can have impact and find use in a much broader setting within and outside life sciences.

KW - Drug Delivery Systems

KW - Imaging, Three-Dimensional

KW - Individualized Medicine

KW - Individualized Medicine: methods

KW - Interferometry

KW - Interferometry: methods

KW - Microfluidic Analytical Techniques

KW - Microscopy, Interference

KW - Nanostructures

KW - Pharmaceutical Preparations

KW - Pharmaceutical Preparations: chemical synthesis

KW - Polymers

KW - Polymers: chemistry

KW - Printing

KW - Surface Properties

U2 - 10.1038/srep04020

DO - 10.1038/srep04020

M3 - Journal article

C2 - 24503863

VL - 4

SP - 4020

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

ER -

ID: 145539243