Preparation of poly (alkylcyanoacrylate) nanoparticles by polymerization of water-free microemulsions

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Preparation of poly (alkylcyanoacrylate) nanoparticles by polymerization of water-free microemulsions. / Krauel, Karen; Graf, Anja; Hook, Sarah M; Davies, Nigel M; Rades, Thomas.

In: Journal of Microencapsulation, Vol. 23, No. 5, 2006, p. 499-512.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Krauel, K, Graf, A, Hook, SM, Davies, NM & Rades, T 2006, 'Preparation of poly (alkylcyanoacrylate) nanoparticles by polymerization of water-free microemulsions', Journal of Microencapsulation, vol. 23, no. 5, pp. 499-512. https://doi.org/10.1080/02652040600687506

APA

Krauel, K., Graf, A., Hook, S. M., Davies, N. M., & Rades, T. (2006). Preparation of poly (alkylcyanoacrylate) nanoparticles by polymerization of water-free microemulsions. Journal of Microencapsulation, 23(5), 499-512. https://doi.org/10.1080/02652040600687506

Vancouver

Krauel K, Graf A, Hook SM, Davies NM, Rades T. Preparation of poly (alkylcyanoacrylate) nanoparticles by polymerization of water-free microemulsions. Journal of Microencapsulation. 2006;23(5):499-512. https://doi.org/10.1080/02652040600687506

Author

Krauel, Karen ; Graf, Anja ; Hook, Sarah M ; Davies, Nigel M ; Rades, Thomas. / Preparation of poly (alkylcyanoacrylate) nanoparticles by polymerization of water-free microemulsions. In: Journal of Microencapsulation. 2006 ; Vol. 23, No. 5. pp. 499-512.

Bibtex

@article{80ac8f28989e4236848d12c60ca23f59,
title = "Preparation of poly (alkylcyanoacrylate) nanoparticles by polymerization of water-free microemulsions",
abstract = "Phase diagrams of the pseudoternary systems ethyloleate, polyoxyethylene 20 sorbitan mono-oleate/sorbitan monolaurate and propylene glycol with and without butanol as a co-surfactant were prepared. Areas containing optically isotropic, one-phase systems were identified and samples therein designated as droplet, bicontinuous or solution type microemulsions using conductivity, viscosity and self-diffusion NMR. Nanoparticles were prepared by polymerization of selected microemulsions with ethyl-2-cyanoacrylate and the morphology of the particles was investigated. Addition of monomer to all types of microemulsions led to the formation of nanoparticles, which had an average size of 244 +/- 25 nm, an average polydispersity index of 0.15 +/- 0.04 and a zeta-potential of -17 +/- 3 mV. The formation of particles from water-free microemulsions of different types is surprising, particularly considering that polymerization is expected to occur at a water-oil interface by base-catalysed polymerization. It would appear that propylene glycol is sufficiently nucleophilic to initiate the polymerization. The use of water-free microemulsions as templates for the preparation of poly (alkylcyanoacrylate) nanoparticles opens up interesting opportunities for the encapsulation of bioactives which do not have suitable properties for encapsulation on the basis of water-containing microemulsions.",
keywords = "Cyanoacrylates, Diffusion, Drug Compounding, Electric Conductivity, Emulsions, Magnetic Resonance Spectroscopy, Microscopy, Electron, Scanning, Nanoparticles, Particle Size, Polymers, Propylene Glycol, Solubility, Surface Properties, Surface-Active Agents, Viscosity",
author = "Karen Krauel and Anja Graf and Hook, {Sarah M} and Davies, {Nigel M} and Thomas Rades",
year = "2006",
doi = "10.1080/02652040600687506",
language = "English",
volume = "23",
pages = "499--512",
journal = "Journal of Microencapsulation",
issn = "0265-2048",
publisher = "Taylor & Francis",
number = "5",

}

RIS

TY - JOUR

T1 - Preparation of poly (alkylcyanoacrylate) nanoparticles by polymerization of water-free microemulsions

AU - Krauel, Karen

AU - Graf, Anja

AU - Hook, Sarah M

AU - Davies, Nigel M

AU - Rades, Thomas

PY - 2006

Y1 - 2006

N2 - Phase diagrams of the pseudoternary systems ethyloleate, polyoxyethylene 20 sorbitan mono-oleate/sorbitan monolaurate and propylene glycol with and without butanol as a co-surfactant were prepared. Areas containing optically isotropic, one-phase systems were identified and samples therein designated as droplet, bicontinuous or solution type microemulsions using conductivity, viscosity and self-diffusion NMR. Nanoparticles were prepared by polymerization of selected microemulsions with ethyl-2-cyanoacrylate and the morphology of the particles was investigated. Addition of monomer to all types of microemulsions led to the formation of nanoparticles, which had an average size of 244 +/- 25 nm, an average polydispersity index of 0.15 +/- 0.04 and a zeta-potential of -17 +/- 3 mV. The formation of particles from water-free microemulsions of different types is surprising, particularly considering that polymerization is expected to occur at a water-oil interface by base-catalysed polymerization. It would appear that propylene glycol is sufficiently nucleophilic to initiate the polymerization. The use of water-free microemulsions as templates for the preparation of poly (alkylcyanoacrylate) nanoparticles opens up interesting opportunities for the encapsulation of bioactives which do not have suitable properties for encapsulation on the basis of water-containing microemulsions.

AB - Phase diagrams of the pseudoternary systems ethyloleate, polyoxyethylene 20 sorbitan mono-oleate/sorbitan monolaurate and propylene glycol with and without butanol as a co-surfactant were prepared. Areas containing optically isotropic, one-phase systems were identified and samples therein designated as droplet, bicontinuous or solution type microemulsions using conductivity, viscosity and self-diffusion NMR. Nanoparticles were prepared by polymerization of selected microemulsions with ethyl-2-cyanoacrylate and the morphology of the particles was investigated. Addition of monomer to all types of microemulsions led to the formation of nanoparticles, which had an average size of 244 +/- 25 nm, an average polydispersity index of 0.15 +/- 0.04 and a zeta-potential of -17 +/- 3 mV. The formation of particles from water-free microemulsions of different types is surprising, particularly considering that polymerization is expected to occur at a water-oil interface by base-catalysed polymerization. It would appear that propylene glycol is sufficiently nucleophilic to initiate the polymerization. The use of water-free microemulsions as templates for the preparation of poly (alkylcyanoacrylate) nanoparticles opens up interesting opportunities for the encapsulation of bioactives which do not have suitable properties for encapsulation on the basis of water-containing microemulsions.

KW - Cyanoacrylates

KW - Diffusion

KW - Drug Compounding

KW - Electric Conductivity

KW - Emulsions

KW - Magnetic Resonance Spectroscopy

KW - Microscopy, Electron, Scanning

KW - Nanoparticles

KW - Particle Size

KW - Polymers

KW - Propylene Glycol

KW - Solubility

KW - Surface Properties

KW - Surface-Active Agents

KW - Viscosity

U2 - 10.1080/02652040600687506

DO - 10.1080/02652040600687506

M3 - Journal article

C2 - 16980272

VL - 23

SP - 499

EP - 512

JO - Journal of Microencapsulation

JF - Journal of Microencapsulation

SN - 0265-2048

IS - 5

ER -

ID: 40357353