Potential of surface-eroding poly(ethylene carbonate) for drug delivery to macrophages

Research output: Contribution to journalJournal articlepeer-review

Standard

Potential of surface-eroding poly(ethylene carbonate) for drug delivery to macrophages. / Bohr, Adam; Water, Jorrit J; Wang, Yingya; Arnfast, Lærke; Beck-Broichsitter, Moritz.

In: International Journal of Pharmaceutics, Vol. 511, No. 2, 2016, p. 814-820.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Bohr, A, Water, JJ, Wang, Y, Arnfast, L & Beck-Broichsitter, M 2016, 'Potential of surface-eroding poly(ethylene carbonate) for drug delivery to macrophages', International Journal of Pharmaceutics, vol. 511, no. 2, pp. 814-820. https://doi.org/10.1016/j.ijpharm.2016.07.075

APA

Bohr, A., Water, J. J., Wang, Y., Arnfast, L., & Beck-Broichsitter, M. (2016). Potential of surface-eroding poly(ethylene carbonate) for drug delivery to macrophages. International Journal of Pharmaceutics, 511(2), 814-820. https://doi.org/10.1016/j.ijpharm.2016.07.075

Vancouver

Bohr A, Water JJ, Wang Y, Arnfast L, Beck-Broichsitter M. Potential of surface-eroding poly(ethylene carbonate) for drug delivery to macrophages. International Journal of Pharmaceutics. 2016;511(2):814-820. https://doi.org/10.1016/j.ijpharm.2016.07.075

Author

Bohr, Adam ; Water, Jorrit J ; Wang, Yingya ; Arnfast, Lærke ; Beck-Broichsitter, Moritz. / Potential of surface-eroding poly(ethylene carbonate) for drug delivery to macrophages. In: International Journal of Pharmaceutics. 2016 ; Vol. 511, No. 2. pp. 814-820.

Bibtex

@article{90fee4195d574109893b51725c38fdb5,
title = "Potential of surface-eroding poly(ethylene carbonate) for drug delivery to macrophages",
abstract = "Films composed of poly(ethylene carbonate) (PEC), a biodegradable polymer, were compared with poly(lactide-co-glycolide) (PLGA) films loaded with and without the tuberculosis drug rifampicin to study the characteristics and performance of PEC as a potential carrier for controlled drug delivery to macrophages. All drug-loaded PLGA and PEC films were amorphous indicating good miscibility of the drug in the polymers, even at high drug loading (up to 50wt.%). Polymer degradation studies showed that PLGA degraded slowly via bulk erosion while PEC degraded more rapidly and near-linearly via enzyme mediated surface erosion (by cholesterol esterase). Drug release studies performed with polymer films indicated a diffusion/erosion dependent delivery behavior for PLGA while an almost zero-order drug release profile was observed from PEC due to the controlled polymer degradation process. When exposed to polymer degradation products the murine macrophage cell line J774A.1 showed less susceptibility to PEC than to PLGA. However, when seeding the macrophages on PLGA and PEC films no relevant difference in cell proliferation/growth kinetics was observed. Overall, this study emphasizes that PEC is an attractive polymer for controlled drug release and could provide superior performance to PLGA for some drug delivery applications including the treatment of macrophage infections.",
author = "Adam Bohr and Water, {Jorrit J} and Yingya Wang and L{\ae}rke Arnfast and Moritz Beck-Broichsitter",
note = "Copyright {\textcopyright} 2016 Elsevier B.V. All rights reserved.",
year = "2016",
doi = "10.1016/j.ijpharm.2016.07.075",
language = "English",
volume = "511",
pages = "814--820",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Potential of surface-eroding poly(ethylene carbonate) for drug delivery to macrophages

AU - Bohr, Adam

AU - Water, Jorrit J

AU - Wang, Yingya

AU - Arnfast, Lærke

AU - Beck-Broichsitter, Moritz

N1 - Copyright © 2016 Elsevier B.V. All rights reserved.

PY - 2016

Y1 - 2016

N2 - Films composed of poly(ethylene carbonate) (PEC), a biodegradable polymer, were compared with poly(lactide-co-glycolide) (PLGA) films loaded with and without the tuberculosis drug rifampicin to study the characteristics and performance of PEC as a potential carrier for controlled drug delivery to macrophages. All drug-loaded PLGA and PEC films were amorphous indicating good miscibility of the drug in the polymers, even at high drug loading (up to 50wt.%). Polymer degradation studies showed that PLGA degraded slowly via bulk erosion while PEC degraded more rapidly and near-linearly via enzyme mediated surface erosion (by cholesterol esterase). Drug release studies performed with polymer films indicated a diffusion/erosion dependent delivery behavior for PLGA while an almost zero-order drug release profile was observed from PEC due to the controlled polymer degradation process. When exposed to polymer degradation products the murine macrophage cell line J774A.1 showed less susceptibility to PEC than to PLGA. However, when seeding the macrophages on PLGA and PEC films no relevant difference in cell proliferation/growth kinetics was observed. Overall, this study emphasizes that PEC is an attractive polymer for controlled drug release and could provide superior performance to PLGA for some drug delivery applications including the treatment of macrophage infections.

AB - Films composed of poly(ethylene carbonate) (PEC), a biodegradable polymer, were compared with poly(lactide-co-glycolide) (PLGA) films loaded with and without the tuberculosis drug rifampicin to study the characteristics and performance of PEC as a potential carrier for controlled drug delivery to macrophages. All drug-loaded PLGA and PEC films were amorphous indicating good miscibility of the drug in the polymers, even at high drug loading (up to 50wt.%). Polymer degradation studies showed that PLGA degraded slowly via bulk erosion while PEC degraded more rapidly and near-linearly via enzyme mediated surface erosion (by cholesterol esterase). Drug release studies performed with polymer films indicated a diffusion/erosion dependent delivery behavior for PLGA while an almost zero-order drug release profile was observed from PEC due to the controlled polymer degradation process. When exposed to polymer degradation products the murine macrophage cell line J774A.1 showed less susceptibility to PEC than to PLGA. However, when seeding the macrophages on PLGA and PEC films no relevant difference in cell proliferation/growth kinetics was observed. Overall, this study emphasizes that PEC is an attractive polymer for controlled drug release and could provide superior performance to PLGA for some drug delivery applications including the treatment of macrophage infections.

U2 - 10.1016/j.ijpharm.2016.07.075

DO - 10.1016/j.ijpharm.2016.07.075

M3 - Journal article

C2 - 27492019

VL - 511

SP - 814

EP - 820

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 2

ER -

ID: 164479695