Physical changes of beta-sitosterol crystals in oily suspensions during heating
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Physical changes of beta-sitosterol crystals in oily suspensions during heating. / von Bonsdorff-Nikander, Anna; Lievonen, Satu; Christiansen, Leena; Karjalainen, Milja; Rantanen, Jukka; Yliruusi, Jouko.
In: AAPS PharmSciTech, Vol. 6, No. 3, 2005, p. E413-20.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Physical changes of beta-sitosterol crystals in oily suspensions during heating
AU - von Bonsdorff-Nikander, Anna
AU - Lievonen, Satu
AU - Christiansen, Leena
AU - Karjalainen, Milja
AU - Rantanen, Jukka
AU - Yliruusi, Jouko
PY - 2005
Y1 - 2005
N2 - The aim of this research was to describe the thermal behavior of beta-sitosterol crystals in oil-suspensions with a focus on the role of water during heating. The suspensions were prepared by recrystallization in order to achieve a microcrystalline particle size. The structural changes together with the mechanical properties of the suspensions during heating were studied by using variable temperature X-ray powder diffractometry (VT-XRPD), differential scanning calorimetry (DSC), and dynamic mechanical analysis (DMA). Hydrated beta-sitosterol crystals in an oil-suspension dehydrated, despite the composition of the suspensions, at low temperatures. At high beta-sitosterol concentration, the monohydrate crystal form changed partially to a hemihydrated form, and when only a small amount of water was initially incorporated, the hemihydrate crystal form dehydrated to a mostly anhydrate crystal form. The released water, which was immiscible in the surrounding oil, caused the recrystallization of hydrated beta-sitosterol during cooling. This procedure indicated a reversible dehydration process. Structural and thermal analysis of beta-sitosterol crystals in suspensions, together with mechanical analysis made it possible to understand various physical changes during heating.
AB - The aim of this research was to describe the thermal behavior of beta-sitosterol crystals in oil-suspensions with a focus on the role of water during heating. The suspensions were prepared by recrystallization in order to achieve a microcrystalline particle size. The structural changes together with the mechanical properties of the suspensions during heating were studied by using variable temperature X-ray powder diffractometry (VT-XRPD), differential scanning calorimetry (DSC), and dynamic mechanical analysis (DMA). Hydrated beta-sitosterol crystals in an oil-suspension dehydrated, despite the composition of the suspensions, at low temperatures. At high beta-sitosterol concentration, the monohydrate crystal form changed partially to a hemihydrated form, and when only a small amount of water was initially incorporated, the hemihydrate crystal form dehydrated to a mostly anhydrate crystal form. The released water, which was immiscible in the surrounding oil, caused the recrystallization of hydrated beta-sitosterol during cooling. This procedure indicated a reversible dehydration process. Structural and thermal analysis of beta-sitosterol crystals in suspensions, together with mechanical analysis made it possible to understand various physical changes during heating.
KW - Chemistry, Physical
KW - Crystallization
KW - Hot Temperature
KW - Oils
KW - Physicochemical Phenomena
KW - Sitosterols
KW - Suspensions
U2 - 10.1208/pt060351
DO - 10.1208/pt060351
M3 - Journal article
C2 - 16353999
VL - 6
SP - E413-20
JO - AAPS PharmSciTech
JF - AAPS PharmSciTech
SN - 1530-9932
IS - 3
ER -
ID: 140621755