Phosphatidyl choline-based colloidal systems for dermal and transdermal drug delivery

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Phosphatidyl choline-based colloidal systems for dermal and transdermal drug delivery. / Ferderber, Kristina; Hook, Sarah; Rades, Thomas.

In: Journal of Liposome Research, Vol. 19, No. 4, 2009, p. 267-77.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ferderber, K, Hook, S & Rades, T 2009, 'Phosphatidyl choline-based colloidal systems for dermal and transdermal drug delivery', Journal of Liposome Research, vol. 19, no. 4, pp. 267-77. https://doi.org/10.3109/08982100902814006

APA

Ferderber, K., Hook, S., & Rades, T. (2009). Phosphatidyl choline-based colloidal systems for dermal and transdermal drug delivery. Journal of Liposome Research, 19(4), 267-77. https://doi.org/10.3109/08982100902814006

Vancouver

Ferderber K, Hook S, Rades T. Phosphatidyl choline-based colloidal systems for dermal and transdermal drug delivery. Journal of Liposome Research. 2009;19(4):267-77. https://doi.org/10.3109/08982100902814006

Author

Ferderber, Kristina ; Hook, Sarah ; Rades, Thomas. / Phosphatidyl choline-based colloidal systems for dermal and transdermal drug delivery. In: Journal of Liposome Research. 2009 ; Vol. 19, No. 4. pp. 267-77.

Bibtex

@article{aa8051bbb77e4442a002926a5f6185d3,
title = "Phosphatidyl choline-based colloidal systems for dermal and transdermal drug delivery",
abstract = "In this study we have prepared various phosphatidyl choline based colloidal systems, namely liposomes, transfersomes, microemulsions and micelles, using similar excipients and compared their ability to deliver drugs into and through the skin under occlusive and non-occlusive conditions. Hydrophilic propranolol hydrochloride (PHCl) and lipophilic propranolol base (PB) were used as model drugs. All tested parameters, that is formulation composition, drug characteristics and testing conditions, influenced skin permeability and skin retention. A trend was observed showing that the skin permeation as well as skin retention decreases with the amount of phosphatidyl choline in the formulations for both tested model drugs (micelles > transfersomes > liposomes > microemulsion). The lipophilic model drug had higher skin permeability especially when incorporated into the systems containing mainly hydrophilic excipients. Skin retention, however, was not affected by the drug hydrophilicity to the same extent as skin permeability. Occlusion increased both skin retention and skin permeation for both model drugs.",
author = "Kristina Ferderber and Sarah Hook and Thomas Rades",
year = "2009",
doi = "10.3109/08982100902814006",
language = "English",
volume = "19",
pages = "267--77",
journal = "Journal of Liposome Research",
issn = "0898-2104",
publisher = "Taylor & Francis",
number = "4",

}

RIS

TY - JOUR

T1 - Phosphatidyl choline-based colloidal systems for dermal and transdermal drug delivery

AU - Ferderber, Kristina

AU - Hook, Sarah

AU - Rades, Thomas

PY - 2009

Y1 - 2009

N2 - In this study we have prepared various phosphatidyl choline based colloidal systems, namely liposomes, transfersomes, microemulsions and micelles, using similar excipients and compared their ability to deliver drugs into and through the skin under occlusive and non-occlusive conditions. Hydrophilic propranolol hydrochloride (PHCl) and lipophilic propranolol base (PB) were used as model drugs. All tested parameters, that is formulation composition, drug characteristics and testing conditions, influenced skin permeability and skin retention. A trend was observed showing that the skin permeation as well as skin retention decreases with the amount of phosphatidyl choline in the formulations for both tested model drugs (micelles > transfersomes > liposomes > microemulsion). The lipophilic model drug had higher skin permeability especially when incorporated into the systems containing mainly hydrophilic excipients. Skin retention, however, was not affected by the drug hydrophilicity to the same extent as skin permeability. Occlusion increased both skin retention and skin permeation for both model drugs.

AB - In this study we have prepared various phosphatidyl choline based colloidal systems, namely liposomes, transfersomes, microemulsions and micelles, using similar excipients and compared their ability to deliver drugs into and through the skin under occlusive and non-occlusive conditions. Hydrophilic propranolol hydrochloride (PHCl) and lipophilic propranolol base (PB) were used as model drugs. All tested parameters, that is formulation composition, drug characteristics and testing conditions, influenced skin permeability and skin retention. A trend was observed showing that the skin permeation as well as skin retention decreases with the amount of phosphatidyl choline in the formulations for both tested model drugs (micelles > transfersomes > liposomes > microemulsion). The lipophilic model drug had higher skin permeability especially when incorporated into the systems containing mainly hydrophilic excipients. Skin retention, however, was not affected by the drug hydrophilicity to the same extent as skin permeability. Occlusion increased both skin retention and skin permeation for both model drugs.

U2 - 10.3109/08982100902814006

DO - 10.3109/08982100902814006

M3 - Journal article

C2 - 19863162

VL - 19

SP - 267

EP - 277

JO - Journal of Liposome Research

JF - Journal of Liposome Research

SN - 0898-2104

IS - 4

ER -

ID: 40349131