Oscillatory Shear Rheology in Examining the Drug-Polymer Interactions Relevant in Hot Melt Extrusion

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Oscillatory Shear Rheology in Examining the Drug-Polymer Interactions Relevant in Hot Melt Extrusion. / Aho, Johanna; Edinger, Magnus; Botker, Johan; Baldursdottir, Stefania; Rantanen, Jukka.

In: Journal of Pharmaceutical Sciences, Vol. 105, No. 1, 01.2016, p. 160-7.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Aho, J, Edinger, M, Botker, J, Baldursdottir, S & Rantanen, J 2016, 'Oscillatory Shear Rheology in Examining the Drug-Polymer Interactions Relevant in Hot Melt Extrusion', Journal of Pharmaceutical Sciences, vol. 105, no. 1, pp. 160-7. https://doi.org/10.1016/j.xphs.2015.11.029

APA

Aho, J., Edinger, M., Botker, J., Baldursdottir, S., & Rantanen, J. (2016). Oscillatory Shear Rheology in Examining the Drug-Polymer Interactions Relevant in Hot Melt Extrusion. Journal of Pharmaceutical Sciences, 105(1), 160-7. https://doi.org/10.1016/j.xphs.2015.11.029

Vancouver

Aho J, Edinger M, Botker J, Baldursdottir S, Rantanen J. Oscillatory Shear Rheology in Examining the Drug-Polymer Interactions Relevant in Hot Melt Extrusion. Journal of Pharmaceutical Sciences. 2016 Jan;105(1):160-7. https://doi.org/10.1016/j.xphs.2015.11.029

Author

Aho, Johanna ; Edinger, Magnus ; Botker, Johan ; Baldursdottir, Stefania ; Rantanen, Jukka. / Oscillatory Shear Rheology in Examining the Drug-Polymer Interactions Relevant in Hot Melt Extrusion. In: Journal of Pharmaceutical Sciences. 2016 ; Vol. 105, No. 1. pp. 160-7.

Bibtex

@article{41667dc69bd24b1a92878aea93fbb8a0,
title = "Oscillatory Shear Rheology in Examining the Drug-Polymer Interactions Relevant in Hot Melt Extrusion",
abstract = "The flow properties of drug-polymer mixtures have a significant influence on their processability when using techniques such as hot melt extrusion (HME). Suitable extrusion temperature and screw speed to be used in laboratory scale HME were evaluated for mixtures containing 30{\%} of paracetamol (PRC), ibuprofen (IBU), or indomethacin (IND), and 70{\%} of polyethylene oxide, by using small amplitude oscillatory shear rheology. The initial evaluation of the drug:polyethylene oxide solubility was estimated by differential scanning calorimetry of the physical mixtures containing a wide range of weight fractions of the drug substances. Consecutively, the mixtures were extruded, and the maximum plasticizing weight fraction of each drug was determined by means of rheological measurements. IBU was found to have an efficient plasticizing functionality, decreasing the viscosity of the mixtures even above its apparent saturation solubility, whereas IND and PRC initially lowered the viscosity of the mixture slightly but increased it significantly with increasing drug load. The main reason for the enhanced plasticization effect seems to be the lower melting temperature of IBU, which is closer to the used HME temperature, compared to PRC and IND. This study highlights the importance of rheological investigation in understanding the drug-polymer interactions in melt processing.",
author = "Johanna Aho and Magnus Edinger and Johan Botker and Stefania Baldursdottir and Jukka Rantanen",
note = "Copyright {\circledC} 2016. Published by Elsevier Inc.",
year = "2016",
month = "1",
doi = "10.1016/j.xphs.2015.11.029",
language = "English",
volume = "105",
pages = "160--7",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Oscillatory Shear Rheology in Examining the Drug-Polymer Interactions Relevant in Hot Melt Extrusion

AU - Aho, Johanna

AU - Edinger, Magnus

AU - Botker, Johan

AU - Baldursdottir, Stefania

AU - Rantanen, Jukka

N1 - Copyright © 2016. Published by Elsevier Inc.

PY - 2016/1

Y1 - 2016/1

N2 - The flow properties of drug-polymer mixtures have a significant influence on their processability when using techniques such as hot melt extrusion (HME). Suitable extrusion temperature and screw speed to be used in laboratory scale HME were evaluated for mixtures containing 30% of paracetamol (PRC), ibuprofen (IBU), or indomethacin (IND), and 70% of polyethylene oxide, by using small amplitude oscillatory shear rheology. The initial evaluation of the drug:polyethylene oxide solubility was estimated by differential scanning calorimetry of the physical mixtures containing a wide range of weight fractions of the drug substances. Consecutively, the mixtures were extruded, and the maximum plasticizing weight fraction of each drug was determined by means of rheological measurements. IBU was found to have an efficient plasticizing functionality, decreasing the viscosity of the mixtures even above its apparent saturation solubility, whereas IND and PRC initially lowered the viscosity of the mixture slightly but increased it significantly with increasing drug load. The main reason for the enhanced plasticization effect seems to be the lower melting temperature of IBU, which is closer to the used HME temperature, compared to PRC and IND. This study highlights the importance of rheological investigation in understanding the drug-polymer interactions in melt processing.

AB - The flow properties of drug-polymer mixtures have a significant influence on their processability when using techniques such as hot melt extrusion (HME). Suitable extrusion temperature and screw speed to be used in laboratory scale HME were evaluated for mixtures containing 30% of paracetamol (PRC), ibuprofen (IBU), or indomethacin (IND), and 70% of polyethylene oxide, by using small amplitude oscillatory shear rheology. The initial evaluation of the drug:polyethylene oxide solubility was estimated by differential scanning calorimetry of the physical mixtures containing a wide range of weight fractions of the drug substances. Consecutively, the mixtures were extruded, and the maximum plasticizing weight fraction of each drug was determined by means of rheological measurements. IBU was found to have an efficient plasticizing functionality, decreasing the viscosity of the mixtures even above its apparent saturation solubility, whereas IND and PRC initially lowered the viscosity of the mixture slightly but increased it significantly with increasing drug load. The main reason for the enhanced plasticization effect seems to be the lower melting temperature of IBU, which is closer to the used HME temperature, compared to PRC and IND. This study highlights the importance of rheological investigation in understanding the drug-polymer interactions in melt processing.

U2 - 10.1016/j.xphs.2015.11.029

DO - 10.1016/j.xphs.2015.11.029

M3 - Journal article

VL - 105

SP - 160

EP - 167

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 1

ER -

ID: 156965036