Optimizing the crystal size and habit of beta-sitosterol in suspension

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Optimizing the crystal size and habit of beta-sitosterol in suspension. / von Bonsdorff-Nikander, Anna; Rantanen, Jukka; Christiansen, Leena; Yliruusi, Jouko.

In: AAPS PharmSciTech, Vol. 4, No. 3, 2003, p. E44.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

von Bonsdorff-Nikander, A, Rantanen, J, Christiansen, L & Yliruusi, J 2003, 'Optimizing the crystal size and habit of beta-sitosterol in suspension', AAPS PharmSciTech, vol. 4, no. 3, pp. E44. https://doi.org/10.1208/pt040344

APA

von Bonsdorff-Nikander, A., Rantanen, J., Christiansen, L., & Yliruusi, J. (2003). Optimizing the crystal size and habit of beta-sitosterol in suspension. AAPS PharmSciTech, 4(3), E44. https://doi.org/10.1208/pt040344

Vancouver

von Bonsdorff-Nikander A, Rantanen J, Christiansen L, Yliruusi J. Optimizing the crystal size and habit of beta-sitosterol in suspension. AAPS PharmSciTech. 2003;4(3):E44. https://doi.org/10.1208/pt040344

Author

von Bonsdorff-Nikander, Anna ; Rantanen, Jukka ; Christiansen, Leena ; Yliruusi, Jouko. / Optimizing the crystal size and habit of beta-sitosterol in suspension. In: AAPS PharmSciTech. 2003 ; Vol. 4, No. 3. pp. E44.

Bibtex

@article{829cb30420224f079d55be2b5bcf842e,
title = "Optimizing the crystal size and habit of beta-sitosterol in suspension",
abstract = "The aim of this work was to survey how processing parameters affect the crystal growth of beta-sitosterol in suspension. The process variables studied were the cooling temperature, stirring time and stirring rate during recrystallization. In addition, we investigated the effect a commonly used surfactant, polysorbate 80, has on crystal size distribution and the polymorphic form. This study describes the optimization of the crystallization process, with the object of preparing crystals as small as possible. Particle size distribution and habit were analyzed using optical microscopy, and the crystal structure was analyzed using X-ray diffractometry. The cooling temperature had a remarkable influence on the crystal size. Crystals with a median crystal length of approximately 23 microm were achieved with a low cooling temperature (<10 degrees C); however, a fairly large number of crystals over 50 microm appeared. Higher cooling temperatures (>30 degrees C) caused notable crystal growth both in length and width. Rapid (250 rpm), continuous stirring until the suspensions had cooled to room temperature created small, less than 50 micro m long (median <20 microm), needle-shaped crystals. The addition of surfactant slightly reduced the size of the initially large crystals. Both hemihydrate and monohydrate crystal forms occurred throughout, regardless of the processing parameters. By using an optimized process, it was possible to obtain a microcrystalline suspension, with a smooth texture.",
keywords = "Chemistry, Pharmaceutical, Cold Temperature, Crystallization, Particle Size, Sitosterols, Surface-Active Agents, Suspensions, Temperature, Time Factors, X-Ray Diffraction",
author = "{von Bonsdorff-Nikander}, Anna and Jukka Rantanen and Leena Christiansen and Jouko Yliruusi",
year = "2003",
doi = "10.1208/pt040344",
language = "English",
volume = "4",
pages = "E44",
journal = "A A P S PharmSciTech",
issn = "1530-9932",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Optimizing the crystal size and habit of beta-sitosterol in suspension

AU - von Bonsdorff-Nikander, Anna

AU - Rantanen, Jukka

AU - Christiansen, Leena

AU - Yliruusi, Jouko

PY - 2003

Y1 - 2003

N2 - The aim of this work was to survey how processing parameters affect the crystal growth of beta-sitosterol in suspension. The process variables studied were the cooling temperature, stirring time and stirring rate during recrystallization. In addition, we investigated the effect a commonly used surfactant, polysorbate 80, has on crystal size distribution and the polymorphic form. This study describes the optimization of the crystallization process, with the object of preparing crystals as small as possible. Particle size distribution and habit were analyzed using optical microscopy, and the crystal structure was analyzed using X-ray diffractometry. The cooling temperature had a remarkable influence on the crystal size. Crystals with a median crystal length of approximately 23 microm were achieved with a low cooling temperature (<10 degrees C); however, a fairly large number of crystals over 50 microm appeared. Higher cooling temperatures (>30 degrees C) caused notable crystal growth both in length and width. Rapid (250 rpm), continuous stirring until the suspensions had cooled to room temperature created small, less than 50 micro m long (median <20 microm), needle-shaped crystals. The addition of surfactant slightly reduced the size of the initially large crystals. Both hemihydrate and monohydrate crystal forms occurred throughout, regardless of the processing parameters. By using an optimized process, it was possible to obtain a microcrystalline suspension, with a smooth texture.

AB - The aim of this work was to survey how processing parameters affect the crystal growth of beta-sitosterol in suspension. The process variables studied were the cooling temperature, stirring time and stirring rate during recrystallization. In addition, we investigated the effect a commonly used surfactant, polysorbate 80, has on crystal size distribution and the polymorphic form. This study describes the optimization of the crystallization process, with the object of preparing crystals as small as possible. Particle size distribution and habit were analyzed using optical microscopy, and the crystal structure was analyzed using X-ray diffractometry. The cooling temperature had a remarkable influence on the crystal size. Crystals with a median crystal length of approximately 23 microm were achieved with a low cooling temperature (<10 degrees C); however, a fairly large number of crystals over 50 microm appeared. Higher cooling temperatures (>30 degrees C) caused notable crystal growth both in length and width. Rapid (250 rpm), continuous stirring until the suspensions had cooled to room temperature created small, less than 50 micro m long (median <20 microm), needle-shaped crystals. The addition of surfactant slightly reduced the size of the initially large crystals. Both hemihydrate and monohydrate crystal forms occurred throughout, regardless of the processing parameters. By using an optimized process, it was possible to obtain a microcrystalline suspension, with a smooth texture.

KW - Chemistry, Pharmaceutical

KW - Cold Temperature

KW - Crystallization

KW - Particle Size

KW - Sitosterols

KW - Surface-Active Agents

KW - Suspensions

KW - Temperature

KW - Time Factors

KW - X-Ray Diffraction

U2 - 10.1208/pt040344

DO - 10.1208/pt040344

M3 - Journal article

C2 - 14621976

VL - 4

SP - E44

JO - A A P S PharmSciTech

JF - A A P S PharmSciTech

SN - 1530-9932

IS - 3

ER -

ID: 140623379