Novel chitosan-magnesium aluminum silicate nanocomposite film coatings for modified-release tablets

Research output: Contribution to journalJournal articlepeer-review

Standard

Novel chitosan-magnesium aluminum silicate nanocomposite film coatings for modified-release tablets. / Khunawattanakul, Wanwisa; Puttipipatkhachorn, Satit; Rades, Thomas; Pongjanyakul, Thaned.

In: International Journal of Pharmaceutics, Vol. 407, No. 1-2, 2011, p. 132-41.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Khunawattanakul, W, Puttipipatkhachorn, S, Rades, T & Pongjanyakul, T 2011, 'Novel chitosan-magnesium aluminum silicate nanocomposite film coatings for modified-release tablets', International Journal of Pharmaceutics, vol. 407, no. 1-2, pp. 132-41. https://doi.org/10.1016/j.ijpharm.2011.01.049

APA

Khunawattanakul, W., Puttipipatkhachorn, S., Rades, T., & Pongjanyakul, T. (2011). Novel chitosan-magnesium aluminum silicate nanocomposite film coatings for modified-release tablets. International Journal of Pharmaceutics, 407(1-2), 132-41. https://doi.org/10.1016/j.ijpharm.2011.01.049

Vancouver

Khunawattanakul W, Puttipipatkhachorn S, Rades T, Pongjanyakul T. Novel chitosan-magnesium aluminum silicate nanocomposite film coatings for modified-release tablets. International Journal of Pharmaceutics. 2011;407(1-2):132-41. https://doi.org/10.1016/j.ijpharm.2011.01.049

Author

Khunawattanakul, Wanwisa ; Puttipipatkhachorn, Satit ; Rades, Thomas ; Pongjanyakul, Thaned. / Novel chitosan-magnesium aluminum silicate nanocomposite film coatings for modified-release tablets. In: International Journal of Pharmaceutics. 2011 ; Vol. 407, No. 1-2. pp. 132-41.

Bibtex

@article{a2d316b6df6d4d1da1ceab3e1a349280,
title = "Novel chitosan-magnesium aluminum silicate nanocomposite film coatings for modified-release tablets",
abstract = "Chitosan (CS), a positively charged polysaccharide, and magnesium aluminum silicate (MAS), a negatively charged clay with silicate layers, can electrostatically interact to form nanocomposite films. In this study, CS-MAS nanocomposite films were evaluated for use in tablet film coating. Effects of CS-MAS ratio and coating level on water uptake and drug release from the coated tablets were investigated. Surface and film matrix morphology of the coated film and the effect of enzymes in the simulated gastro-intestinal fluid on drug release were also examined. The results demonstrated that the CS-MAS coated tablets had a rough surface and a layered matrix film, whereas a smooth surface and dense matrix film on the CS coated tablets was found. However, the CS-MAS coated tablets provided fewer film defects than the CS coated tablets. Nanocomposite formation between CS and MAS could retard swelling and erosion of CS in the composite films in acidic medium. The higher MAS ratio of the CS-MAS coated tablets gave lower water uptake and slower drug release when compared with the CS coated tablets. Moreover, the CS-MAS films on the tablets presented good stability towards enzymatic degradation in simulated intestinal fluid. The release of drug from the CS-MAS coated tablets could be modulated by varying CS-MAS ratios and coating levels. Additionally, drug solubility also influenced drug release characteristics of the CS-MAS coated tablets. These findings suggest that the CS-MAS nanocomposites displays a strong potential for use in tablet film coating intended for modifying drug release from tablets.",
author = "Wanwisa Khunawattanakul and Satit Puttipipatkhachorn and Thomas Rades and Thaned Pongjanyakul",
note = "Copyright {\textcopyright} 2011 Elsevier B.V. All rights reserved.",
year = "2011",
doi = "10.1016/j.ijpharm.2011.01.049",
language = "English",
volume = "407",
pages = "132--41",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Novel chitosan-magnesium aluminum silicate nanocomposite film coatings for modified-release tablets

AU - Khunawattanakul, Wanwisa

AU - Puttipipatkhachorn, Satit

AU - Rades, Thomas

AU - Pongjanyakul, Thaned

N1 - Copyright © 2011 Elsevier B.V. All rights reserved.

PY - 2011

Y1 - 2011

N2 - Chitosan (CS), a positively charged polysaccharide, and magnesium aluminum silicate (MAS), a negatively charged clay with silicate layers, can electrostatically interact to form nanocomposite films. In this study, CS-MAS nanocomposite films were evaluated for use in tablet film coating. Effects of CS-MAS ratio and coating level on water uptake and drug release from the coated tablets were investigated. Surface and film matrix morphology of the coated film and the effect of enzymes in the simulated gastro-intestinal fluid on drug release were also examined. The results demonstrated that the CS-MAS coated tablets had a rough surface and a layered matrix film, whereas a smooth surface and dense matrix film on the CS coated tablets was found. However, the CS-MAS coated tablets provided fewer film defects than the CS coated tablets. Nanocomposite formation between CS and MAS could retard swelling and erosion of CS in the composite films in acidic medium. The higher MAS ratio of the CS-MAS coated tablets gave lower water uptake and slower drug release when compared with the CS coated tablets. Moreover, the CS-MAS films on the tablets presented good stability towards enzymatic degradation in simulated intestinal fluid. The release of drug from the CS-MAS coated tablets could be modulated by varying CS-MAS ratios and coating levels. Additionally, drug solubility also influenced drug release characteristics of the CS-MAS coated tablets. These findings suggest that the CS-MAS nanocomposites displays a strong potential for use in tablet film coating intended for modifying drug release from tablets.

AB - Chitosan (CS), a positively charged polysaccharide, and magnesium aluminum silicate (MAS), a negatively charged clay with silicate layers, can electrostatically interact to form nanocomposite films. In this study, CS-MAS nanocomposite films were evaluated for use in tablet film coating. Effects of CS-MAS ratio and coating level on water uptake and drug release from the coated tablets were investigated. Surface and film matrix morphology of the coated film and the effect of enzymes in the simulated gastro-intestinal fluid on drug release were also examined. The results demonstrated that the CS-MAS coated tablets had a rough surface and a layered matrix film, whereas a smooth surface and dense matrix film on the CS coated tablets was found. However, the CS-MAS coated tablets provided fewer film defects than the CS coated tablets. Nanocomposite formation between CS and MAS could retard swelling and erosion of CS in the composite films in acidic medium. The higher MAS ratio of the CS-MAS coated tablets gave lower water uptake and slower drug release when compared with the CS coated tablets. Moreover, the CS-MAS films on the tablets presented good stability towards enzymatic degradation in simulated intestinal fluid. The release of drug from the CS-MAS coated tablets could be modulated by varying CS-MAS ratios and coating levels. Additionally, drug solubility also influenced drug release characteristics of the CS-MAS coated tablets. These findings suggest that the CS-MAS nanocomposites displays a strong potential for use in tablet film coating intended for modifying drug release from tablets.

U2 - 10.1016/j.ijpharm.2011.01.049

DO - 10.1016/j.ijpharm.2011.01.049

M3 - Journal article

C2 - 21291977

VL - 407

SP - 132

EP - 141

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 40340016