Near-Infrared Imaging for High-Throughput Screening of Moisture-Induced Changes in Freeze-Dried Formulations

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Near-Infrared Imaging for High-Throughput Screening of Moisture-Induced Changes in Freeze-Dried Formulations. / Trnka, Hjalte; Palou, Anna; Panouillot, Pierre Emanuel; Kauppinen, Ari; Toiviainen, Maunu; Grohganz, Holger; Alcalà, Manel; Juuti, Mikko; Ketolainen, Jarkko; Rantanen, Jukka.

In: Journal of Pharmaceutical Sciences, Vol. 103, No. 9, 24.03.2014, p. 2839–2846.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Trnka, H, Palou, A, Panouillot, PE, Kauppinen, A, Toiviainen, M, Grohganz, H, Alcalà, M, Juuti, M, Ketolainen, J & Rantanen, J 2014, 'Near-Infrared Imaging for High-Throughput Screening of Moisture-Induced Changes in Freeze-Dried Formulations', Journal of Pharmaceutical Sciences, vol. 103, no. 9, pp. 2839–2846. https://doi.org/10.1002/jps.23948

APA

Trnka, H., Palou, A., Panouillot, P. E., Kauppinen, A., Toiviainen, M., Grohganz, H., ... Rantanen, J. (2014). Near-Infrared Imaging for High-Throughput Screening of Moisture-Induced Changes in Freeze-Dried Formulations. Journal of Pharmaceutical Sciences, 103(9), 2839–2846. https://doi.org/10.1002/jps.23948

Vancouver

Trnka H, Palou A, Panouillot PE, Kauppinen A, Toiviainen M, Grohganz H et al. Near-Infrared Imaging for High-Throughput Screening of Moisture-Induced Changes in Freeze-Dried Formulations. Journal of Pharmaceutical Sciences. 2014 Mar 24;103(9):2839–2846. https://doi.org/10.1002/jps.23948

Author

Trnka, Hjalte ; Palou, Anna ; Panouillot, Pierre Emanuel ; Kauppinen, Ari ; Toiviainen, Maunu ; Grohganz, Holger ; Alcalà, Manel ; Juuti, Mikko ; Ketolainen, Jarkko ; Rantanen, Jukka. / Near-Infrared Imaging for High-Throughput Screening of Moisture-Induced Changes in Freeze-Dried Formulations. In: Journal of Pharmaceutical Sciences. 2014 ; Vol. 103, No. 9. pp. 2839–2846.

Bibtex

@article{094b45ccbfa842b2b5e218c3a8587fc6,
title = "Near-Infrared Imaging for High-Throughput Screening of Moisture-Induced Changes in Freeze-Dried Formulations",
abstract = "Evaluation of freeze-dried biopharmaceutical formulations requires careful analysis of multiple quality attributes. The aim of this study was to evaluate the use of near-infrared (NIR) imaging for fast analysis of water content and related physical properties in freeze-dried formulations. Model formulations were freeze-dried in well plates. Samples were imaged with a NIR hyperspectral camera after freeze-drying and upon storage. On the basis of Karl Fischer titration reference values, a univariate quantification model was constructed and used to visualize the distribution of water within freeze-dried samples. Differences observed between samples stored at 11{\%} and 43{\%} relative humidity (RH) were found to be related to the amount of amorphous component in the sample. When stored at 43{\%} RH, the moisture content in samples with high sucrose content increased within 2 days and some degree of localized drying was observed within the samples after 3 days of storage. Further investigations with X-ray powder diffraction confirmed this local drying to be related to crystallization of sucrose. The combination of fast analysis of water content and spatial solid-state information makes NIR imaging a powerful tool for formulation development of freeze-dried samples. {\circledC} 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.",
author = "Hjalte Trnka and Anna Palou and Panouillot, {Pierre Emanuel} and Ari Kauppinen and Maunu Toiviainen and Holger Grohganz and Manel Alcal{\`a} and Mikko Juuti and Jarkko Ketolainen and Jukka Rantanen",
note = "{\circledC} 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.",
year = "2014",
month = "3",
day = "24",
doi = "10.1002/jps.23948",
language = "English",
volume = "103",
pages = "2839–2846",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "9",

}

RIS

TY - JOUR

T1 - Near-Infrared Imaging for High-Throughput Screening of Moisture-Induced Changes in Freeze-Dried Formulations

AU - Trnka, Hjalte

AU - Palou, Anna

AU - Panouillot, Pierre Emanuel

AU - Kauppinen, Ari

AU - Toiviainen, Maunu

AU - Grohganz, Holger

AU - Alcalà, Manel

AU - Juuti, Mikko

AU - Ketolainen, Jarkko

AU - Rantanen, Jukka

N1 - © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

PY - 2014/3/24

Y1 - 2014/3/24

N2 - Evaluation of freeze-dried biopharmaceutical formulations requires careful analysis of multiple quality attributes. The aim of this study was to evaluate the use of near-infrared (NIR) imaging for fast analysis of water content and related physical properties in freeze-dried formulations. Model formulations were freeze-dried in well plates. Samples were imaged with a NIR hyperspectral camera after freeze-drying and upon storage. On the basis of Karl Fischer titration reference values, a univariate quantification model was constructed and used to visualize the distribution of water within freeze-dried samples. Differences observed between samples stored at 11% and 43% relative humidity (RH) were found to be related to the amount of amorphous component in the sample. When stored at 43% RH, the moisture content in samples with high sucrose content increased within 2 days and some degree of localized drying was observed within the samples after 3 days of storage. Further investigations with X-ray powder diffraction confirmed this local drying to be related to crystallization of sucrose. The combination of fast analysis of water content and spatial solid-state information makes NIR imaging a powerful tool for formulation development of freeze-dried samples. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.

AB - Evaluation of freeze-dried biopharmaceutical formulations requires careful analysis of multiple quality attributes. The aim of this study was to evaluate the use of near-infrared (NIR) imaging for fast analysis of water content and related physical properties in freeze-dried formulations. Model formulations were freeze-dried in well plates. Samples were imaged with a NIR hyperspectral camera after freeze-drying and upon storage. On the basis of Karl Fischer titration reference values, a univariate quantification model was constructed and used to visualize the distribution of water within freeze-dried samples. Differences observed between samples stored at 11% and 43% relative humidity (RH) were found to be related to the amount of amorphous component in the sample. When stored at 43% RH, the moisture content in samples with high sucrose content increased within 2 days and some degree of localized drying was observed within the samples after 3 days of storage. Further investigations with X-ray powder diffraction confirmed this local drying to be related to crystallization of sucrose. The combination of fast analysis of water content and spatial solid-state information makes NIR imaging a powerful tool for formulation development of freeze-dried samples. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.

U2 - 10.1002/jps.23948

DO - 10.1002/jps.23948

M3 - Journal article

C2 - 24665039

VL - 103

SP - 2839

EP - 2846

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 9

ER -

ID: 113037218