Molluscicidal saponins from a Zimbabwean strain of Phytolacca dodecandra
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Molluscicidal saponins from a Zimbabwean strain of Phytolacca dodecandra. / Thiilborg, S. T.; Christensen, S. B.; Cornett, Claus; Olsen, C. E.; Lemmich, E.
In: Phytochemistry, Vol. 36, No. 3, 1994, p. 753-759.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Molluscicidal saponins from a Zimbabwean strain of Phytolacca dodecandra
AU - Thiilborg, S. T.
AU - Christensen, S. B.
AU - Cornett, Claus
AU - Olsen, C. E.
AU - Lemmich, E.
PY - 1994
Y1 - 1994
N2 - Three new monodesmosidic saponins, all glycosides of 2 beta-hydroxyoleanolic acid, were isolated from an aqueous extract of a Zimbabwean strain of Phytolacca dodecandra. Their structures were, mainly by spectroscopic methods (LSIMS, H-1 NMR, COSY, NOESY, TOCSY, J-resolved (1)HNMR, (13)CNMR, HETCOR), established as 3-O-[2',4'-di-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosyl]2 beta-hydroxyoleanolic acid, 3-OO-alpha-L-rhamnopyranosyl-(1-->2)-O-[beta-D-galactopyranosyl- (1-->3)]-beta-D-glucopyranosyl 2 beta-hydroxyoleanolic acid and 3-O-[3'-O-(beta-D-galactopyranosyl)-beta-D-glucopyranosyl] 2 beta-hydroxyoleanolic acid. Two of the saponins were submitted to a preliminary screening for molluscicidal activity against the schistosomiasis transmitting snail Biomphalaria glabrata and showed, respectively, strong and weak activity. In addition, four saponins previously reported from other strains of Phytolacca dodecandra were identified.
AB - Three new monodesmosidic saponins, all glycosides of 2 beta-hydroxyoleanolic acid, were isolated from an aqueous extract of a Zimbabwean strain of Phytolacca dodecandra. Their structures were, mainly by spectroscopic methods (LSIMS, H-1 NMR, COSY, NOESY, TOCSY, J-resolved (1)HNMR, (13)CNMR, HETCOR), established as 3-O-[2',4'-di-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosyl]2 beta-hydroxyoleanolic acid, 3-OO-alpha-L-rhamnopyranosyl-(1-->2)-O-[beta-D-galactopyranosyl- (1-->3)]-beta-D-glucopyranosyl 2 beta-hydroxyoleanolic acid and 3-O-[3'-O-(beta-D-galactopyranosyl)-beta-D-glucopyranosyl] 2 beta-hydroxyoleanolic acid. Two of the saponins were submitted to a preliminary screening for molluscicidal activity against the schistosomiasis transmitting snail Biomphalaria glabrata and showed, respectively, strong and weak activity. In addition, four saponins previously reported from other strains of Phytolacca dodecandra were identified.
KW - phytolacca dodecandra phytolaccaceae zimbabwean strain molluscicides triterpene saponins 2-hydroxyoleanolic acid oleanolic acid hemolytic activity lherit
M3 - Tidsskriftartikel
VL - 36
SP - 753
EP - 759
JO - Phytochemistry
JF - Phytochemistry
SN - 0031-9422
IS - 3
ER -
ID: 38062315