Molecular weight-dependent degradation and drug release of surface-eroding poly(ethylene carbonate)

Research output: Contribution to journalJournal articlepeer-review

Standard

Molecular weight-dependent degradation and drug release of surface-eroding poly(ethylene carbonate). / Bohr, Adam; Wang, Yingya; Harmankaya, Necati; Water, Jorrit Jeroen; Baldursdottir, Stefania G.; Almdal, Kristoffer; Beck-Broichsitter, Moritz.

In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 115, 2017, p. 140-148.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Bohr, A, Wang, Y, Harmankaya, N, Water, JJ, Baldursdottir, SG, Almdal, K & Beck-Broichsitter, M 2017, 'Molecular weight-dependent degradation and drug release of surface-eroding poly(ethylene carbonate)', European Journal of Pharmaceutics and Biopharmaceutics, vol. 115, pp. 140-148. https://doi.org/10.1016/j.ejpb.2017.02.011

APA

Bohr, A., Wang, Y., Harmankaya, N., Water, J. J., Baldursdottir, S. G., Almdal, K., & Beck-Broichsitter, M. (2017). Molecular weight-dependent degradation and drug release of surface-eroding poly(ethylene carbonate). European Journal of Pharmaceutics and Biopharmaceutics, 115, 140-148. https://doi.org/10.1016/j.ejpb.2017.02.011

Vancouver

Bohr A, Wang Y, Harmankaya N, Water JJ, Baldursdottir SG, Almdal K et al. Molecular weight-dependent degradation and drug release of surface-eroding poly(ethylene carbonate). European Journal of Pharmaceutics and Biopharmaceutics. 2017;115:140-148. https://doi.org/10.1016/j.ejpb.2017.02.011

Author

Bohr, Adam ; Wang, Yingya ; Harmankaya, Necati ; Water, Jorrit Jeroen ; Baldursdottir, Stefania G. ; Almdal, Kristoffer ; Beck-Broichsitter, Moritz. / Molecular weight-dependent degradation and drug release of surface-eroding poly(ethylene carbonate). In: European Journal of Pharmaceutics and Biopharmaceutics. 2017 ; Vol. 115. pp. 140-148.

Bibtex

@article{ef8bb98a00224157b61c4434593a6293,
title = "Molecular weight-dependent degradation and drug release of surface-eroding poly(ethylene carbonate)",
abstract = "Poly(ethylene carbonate) (PEC) is a unique biomaterial showing significant potential for controlled drug delivery applications. The current study investigated the impact of the molecular weight on the biological performance of drug-loaded PEC films. Following the preparation and thorough physicochemical characterization of diverse PEC (molecular weights: 85, 110, 133, 174 and 196kDa), the degradation and drug release behavior of rifampicin- and bovine serum albumin-loaded PEC films was investigated in vitro (in the presence and absence of cholesterol esterase), in cell culture (RAW264.7 macrophages) and in vivo (subcutaneous implantation in rats). All investigated samples degraded by means of surface erosion (mass loss, but constant molecular weight), which was accompanied by a predictable, erosion-controlled drug release pattern. Accordingly, the obtained in vitro degradation half-lives correlated well with the observed in vitro half-times of drug delivery (R2=0.96). Here, the PEC of the highest molecular weight resulted in the fastest degradation/drug release. When incubated with macrophages or implanted in animals, the degradation rate of PEC films superimposed the results of in vitro incubations with cholesterol esterase. Interestingly, SEM analysis indicated a distinct surface erosion process for enzyme-, macrophage- and in vivo-treated polymer films in a molecular weight-dependent manner. Overall, the molecular weight of surface-eroding PEC was identified as an essential parameter to control the spatial and temporal on-demand degradation and drug release from the employed delivery system.",
author = "Adam Bohr and Yingya Wang and Necati Harmankaya and Water, {Jorrit Jeroen} and Baldursdottir, {Stefania G.} and Kristoffer Almdal and Moritz Beck-Broichsitter",
year = "2017",
doi = "10.1016/j.ejpb.2017.02.011",
language = "English",
volume = "115",
pages = "140--148",
journal = "European Journal of Pharmaceutics and Biopharmaceutics",
issn = "0939-6411",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Molecular weight-dependent degradation and drug release of surface-eroding poly(ethylene carbonate)

AU - Bohr, Adam

AU - Wang, Yingya

AU - Harmankaya, Necati

AU - Water, Jorrit Jeroen

AU - Baldursdottir, Stefania G.

AU - Almdal, Kristoffer

AU - Beck-Broichsitter, Moritz

PY - 2017

Y1 - 2017

N2 - Poly(ethylene carbonate) (PEC) is a unique biomaterial showing significant potential for controlled drug delivery applications. The current study investigated the impact of the molecular weight on the biological performance of drug-loaded PEC films. Following the preparation and thorough physicochemical characterization of diverse PEC (molecular weights: 85, 110, 133, 174 and 196kDa), the degradation and drug release behavior of rifampicin- and bovine serum albumin-loaded PEC films was investigated in vitro (in the presence and absence of cholesterol esterase), in cell culture (RAW264.7 macrophages) and in vivo (subcutaneous implantation in rats). All investigated samples degraded by means of surface erosion (mass loss, but constant molecular weight), which was accompanied by a predictable, erosion-controlled drug release pattern. Accordingly, the obtained in vitro degradation half-lives correlated well with the observed in vitro half-times of drug delivery (R2=0.96). Here, the PEC of the highest molecular weight resulted in the fastest degradation/drug release. When incubated with macrophages or implanted in animals, the degradation rate of PEC films superimposed the results of in vitro incubations with cholesterol esterase. Interestingly, SEM analysis indicated a distinct surface erosion process for enzyme-, macrophage- and in vivo-treated polymer films in a molecular weight-dependent manner. Overall, the molecular weight of surface-eroding PEC was identified as an essential parameter to control the spatial and temporal on-demand degradation and drug release from the employed delivery system.

AB - Poly(ethylene carbonate) (PEC) is a unique biomaterial showing significant potential for controlled drug delivery applications. The current study investigated the impact of the molecular weight on the biological performance of drug-loaded PEC films. Following the preparation and thorough physicochemical characterization of diverse PEC (molecular weights: 85, 110, 133, 174 and 196kDa), the degradation and drug release behavior of rifampicin- and bovine serum albumin-loaded PEC films was investigated in vitro (in the presence and absence of cholesterol esterase), in cell culture (RAW264.7 macrophages) and in vivo (subcutaneous implantation in rats). All investigated samples degraded by means of surface erosion (mass loss, but constant molecular weight), which was accompanied by a predictable, erosion-controlled drug release pattern. Accordingly, the obtained in vitro degradation half-lives correlated well with the observed in vitro half-times of drug delivery (R2=0.96). Here, the PEC of the highest molecular weight resulted in the fastest degradation/drug release. When incubated with macrophages or implanted in animals, the degradation rate of PEC films superimposed the results of in vitro incubations with cholesterol esterase. Interestingly, SEM analysis indicated a distinct surface erosion process for enzyme-, macrophage- and in vivo-treated polymer films in a molecular weight-dependent manner. Overall, the molecular weight of surface-eroding PEC was identified as an essential parameter to control the spatial and temporal on-demand degradation and drug release from the employed delivery system.

U2 - 10.1016/j.ejpb.2017.02.011

DO - 10.1016/j.ejpb.2017.02.011

M3 - Journal article

C2 - 28238837

VL - 115

SP - 140

EP - 148

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

SN - 0939-6411

ER -

ID: 173204330