Modular design principle based on compartmental drug delivery systems q

Research output: Contribution to journalReviewpeer-review

Standard

Modular design principle based on compartmental drug delivery systems q. / Eleftheriadis, Georgios K.; Genina, Natalja; Boetker, Johan; Rantanen, Jukka.

In: Advanced Drug Delivery Reviews, Vol. 178, 113921, 2021.

Research output: Contribution to journalReviewpeer-review

Harvard

Eleftheriadis, GK, Genina, N, Boetker, J & Rantanen, J 2021, 'Modular design principle based on compartmental drug delivery systems q', Advanced Drug Delivery Reviews, vol. 178, 113921. https://doi.org/10.1016/j.addr.2021.113921

APA

Eleftheriadis, G. K., Genina, N., Boetker, J., & Rantanen, J. (2021). Modular design principle based on compartmental drug delivery systems q. Advanced Drug Delivery Reviews, 178, [113921]. https://doi.org/10.1016/j.addr.2021.113921

Vancouver

Eleftheriadis GK, Genina N, Boetker J, Rantanen J. Modular design principle based on compartmental drug delivery systems q. Advanced Drug Delivery Reviews. 2021;178. 113921. https://doi.org/10.1016/j.addr.2021.113921

Author

Eleftheriadis, Georgios K. ; Genina, Natalja ; Boetker, Johan ; Rantanen, Jukka. / Modular design principle based on compartmental drug delivery systems q. In: Advanced Drug Delivery Reviews. 2021 ; Vol. 178.

Bibtex

@article{d6837b5539624bd0a8a5d1eee43ddd7f,
title = "Modular design principle based on compartmental drug delivery systems q",
abstract = "The current manufacturing solutions for oral solid dosage forms are fundamentally based on technologies from the 19th century. This approach is well suited for mass production of one-size-fits-all products; however, it does not allow for a straight-forward personalization and mass customization of the pharmaceutical end-product. In order to provide better therapies to the patients, a need for innovative manufacturing concepts and product design principles has been rising. Additive manufacturing opens up a possibility for compartmentalization of drug products, including design of spatially separated multidrug and functional excipient compartments. This compartmentalized solution can be further expanded to modular design thinking. Modular design is referring to combination of building blocks containing a given amount of drug compound(s) and related functional excipients into a larger final product. Implementation of modular design principles is paving the way for implementing the emerging personalization potential within health sciences by designing compartmental and reactive product structures that can be manufactured based on the individual needs of each patient. This review will introduce the existing compartmentalized product design principles and discuss the integration of these into edible electronics allowing for innovative control of drug release. (c) 2021 Published by Elsevier B.V.",
keywords = "Additive manufacturing, 3D printing, Compartmental systems, Modular systems, Drug delivery, Smart medications, Ingestible electronics, Digital reconstruction, Intellectual property, ORODISPERSIBLE FILMS, PRINTED PHARMACEUTICALS, COMBINATION THERAPY, INNOVATIVE APPROACH, ORAL DELIVERY, DOSAGE FORMS, RELEASE, TABLETS, EXTRUSION, ACCEPTABILITY",
author = "Eleftheriadis, {Georgios K.} and Natalja Genina and Johan Boetker and Jukka Rantanen",
year = "2021",
doi = "10.1016/j.addr.2021.113921",
language = "English",
volume = "178",
journal = "Advanced Drug Delivery Reviews",
issn = "0169-409X",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Modular design principle based on compartmental drug delivery systems q

AU - Eleftheriadis, Georgios K.

AU - Genina, Natalja

AU - Boetker, Johan

AU - Rantanen, Jukka

PY - 2021

Y1 - 2021

N2 - The current manufacturing solutions for oral solid dosage forms are fundamentally based on technologies from the 19th century. This approach is well suited for mass production of one-size-fits-all products; however, it does not allow for a straight-forward personalization and mass customization of the pharmaceutical end-product. In order to provide better therapies to the patients, a need for innovative manufacturing concepts and product design principles has been rising. Additive manufacturing opens up a possibility for compartmentalization of drug products, including design of spatially separated multidrug and functional excipient compartments. This compartmentalized solution can be further expanded to modular design thinking. Modular design is referring to combination of building blocks containing a given amount of drug compound(s) and related functional excipients into a larger final product. Implementation of modular design principles is paving the way for implementing the emerging personalization potential within health sciences by designing compartmental and reactive product structures that can be manufactured based on the individual needs of each patient. This review will introduce the existing compartmentalized product design principles and discuss the integration of these into edible electronics allowing for innovative control of drug release. (c) 2021 Published by Elsevier B.V.

AB - The current manufacturing solutions for oral solid dosage forms are fundamentally based on technologies from the 19th century. This approach is well suited for mass production of one-size-fits-all products; however, it does not allow for a straight-forward personalization and mass customization of the pharmaceutical end-product. In order to provide better therapies to the patients, a need for innovative manufacturing concepts and product design principles has been rising. Additive manufacturing opens up a possibility for compartmentalization of drug products, including design of spatially separated multidrug and functional excipient compartments. This compartmentalized solution can be further expanded to modular design thinking. Modular design is referring to combination of building blocks containing a given amount of drug compound(s) and related functional excipients into a larger final product. Implementation of modular design principles is paving the way for implementing the emerging personalization potential within health sciences by designing compartmental and reactive product structures that can be manufactured based on the individual needs of each patient. This review will introduce the existing compartmentalized product design principles and discuss the integration of these into edible electronics allowing for innovative control of drug release. (c) 2021 Published by Elsevier B.V.

KW - Additive manufacturing

KW - 3D printing

KW - Compartmental systems

KW - Modular systems

KW - Drug delivery

KW - Smart medications

KW - Ingestible electronics

KW - Digital reconstruction

KW - Intellectual property

KW - ORODISPERSIBLE FILMS

KW - PRINTED PHARMACEUTICALS

KW - COMBINATION THERAPY

KW - INNOVATIVE APPROACH

KW - ORAL DELIVERY

KW - DOSAGE FORMS

KW - RELEASE

KW - TABLETS

KW - EXTRUSION

KW - ACCEPTABILITY

U2 - 10.1016/j.addr.2021.113921

DO - 10.1016/j.addr.2021.113921

M3 - Review

C2 - 34390776

VL - 178

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

M1 - 113921

ER -

ID: 288273527