Modifying release characteristics from 3D printed drug-eluting products
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Modifying release characteristics from 3D printed drug-eluting products. / Boetker, Johan; Water, Jorrit; Aho, Johanna; Arnfast, Lærke; Bohr, Adam; Rantanen, Jukka.
In: European Journal of Pharmaceutical Sciences, Vol. 90, 2016, p. 47-52.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Modifying release characteristics from 3D printed drug-eluting products
AU - Boetker, Johan
AU - Water, Jorrit
AU - Aho, Johanna
AU - Arnfast, Lærke
AU - Bohr, Adam
AU - Rantanen, Jukka
PY - 2016
Y1 - 2016
N2 - Abstract This work describes an approach to modify the release of active compound from a 3D printed model drug product geometry intended for flexible dosing and precision medication. The production of novel polylactic acid and hydroxypropyl methylcellulose based feed materials containing nitrofurantoin for 3D printing purposes is demonstrated. Nitrofurantoin, Metolose® and polylactic acid were successfully co-extruded with up to 40% Metolose® content, and subsequently 3D printed into model disk geometries (ø10 mm, h = 2 mm). Thermal analysis with differential scanning calorimetry and solid phase identification with Raman spectroscopy showed that nitrofurantoin remained in its original solid form during both hot-melt extrusion and subsequent 3D printing. Rheological measurements of the different compositions showed that the flow properties were sensitive to the amount of undissolved particles present in the formulation. Release of nitrofurantoin from the disks was dependent on Metolose® loading, with higher accumulated release observed for higher Metolose® loads. This work shows the potential of custom-made, drug loaded feed materials for 3D printing of precision drug products with tailored drug release characteristics.
AB - Abstract This work describes an approach to modify the release of active compound from a 3D printed model drug product geometry intended for flexible dosing and precision medication. The production of novel polylactic acid and hydroxypropyl methylcellulose based feed materials containing nitrofurantoin for 3D printing purposes is demonstrated. Nitrofurantoin, Metolose® and polylactic acid were successfully co-extruded with up to 40% Metolose® content, and subsequently 3D printed into model disk geometries (ø10 mm, h = 2 mm). Thermal analysis with differential scanning calorimetry and solid phase identification with Raman spectroscopy showed that nitrofurantoin remained in its original solid form during both hot-melt extrusion and subsequent 3D printing. Rheological measurements of the different compositions showed that the flow properties were sensitive to the amount of undissolved particles present in the formulation. Release of nitrofurantoin from the disks was dependent on Metolose® loading, with higher accumulated release observed for higher Metolose® loads. This work shows the potential of custom-made, drug loaded feed materials for 3D printing of precision drug products with tailored drug release characteristics.
KW - Controlled release/delivery
KW - Polylactic acid (PLA)
KW - Biodegradable polymers
KW - Rheology
KW - Extrusion
KW - 3D printing Biofilm
KW - Antimicrobial Implant
U2 - 10.1016/j.ejps.2016.03.013
DO - 10.1016/j.ejps.2016.03.013
M3 - Tidsskriftartikel
C2 - 26987609
VL - 90
SP - 47
EP - 52
JO - Norvegica Pharmaceutica Acta
JF - Norvegica Pharmaceutica Acta
SN - 0928-0987
ER -
ID: 160046647