Miscibility and interactions between 17beta-estradiol and Eudragit RS in solid dispersion

Research output: Contribution to journalJournal articlepeer-review

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Miscibility and interactions between 17beta-estradiol and Eudragit RS in solid dispersion. / Wiranidchapong, Chutima; Tucker, Ian G; Rades, Thomas; Kulvanich, Poj.

In: Al Azhar Journal of Pharmaceutical Sciences, Vol. 97, No. 11, 2008, p. 4879-88.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Wiranidchapong, C, Tucker, IG, Rades, T & Kulvanich, P 2008, 'Miscibility and interactions between 17beta-estradiol and Eudragit RS in solid dispersion', Al Azhar Journal of Pharmaceutical Sciences, vol. 97, no. 11, pp. 4879-88. https://doi.org/10.1002/jps.21366

APA

Wiranidchapong, C., Tucker, I. G., Rades, T., & Kulvanich, P. (2008). Miscibility and interactions between 17beta-estradiol and Eudragit RS in solid dispersion. Al Azhar Journal of Pharmaceutical Sciences, 97(11), 4879-88. https://doi.org/10.1002/jps.21366

Vancouver

Wiranidchapong C, Tucker IG, Rades T, Kulvanich P. Miscibility and interactions between 17beta-estradiol and Eudragit RS in solid dispersion. Al Azhar Journal of Pharmaceutical Sciences. 2008;97(11):4879-88. https://doi.org/10.1002/jps.21366

Author

Wiranidchapong, Chutima ; Tucker, Ian G ; Rades, Thomas ; Kulvanich, Poj. / Miscibility and interactions between 17beta-estradiol and Eudragit RS in solid dispersion. In: Al Azhar Journal of Pharmaceutical Sciences. 2008 ; Vol. 97, No. 11. pp. 4879-88.

Bibtex

@article{239c06d607c645a6a876a4065cc5b863,
title = "Miscibility and interactions between 17beta-estradiol and Eudragit RS in solid dispersion",
abstract = "Miscibility of 17beta-estradiol and Eudragit RS in solid dispersions was determined by modulated temperature differential scanning calorimetry (MTDSC). A reduction of the 17beta-estradiol melting point in Eudragit RS solid dispersions was observed by MTDSC using heating program I in which the maximum temperature in the first heating run was lower than the 17beta-estradiol melting point. The melting point depression of 17beta-estradiol in solid dispersions as a function of composition could be explained by the Nishi-Wang equation indicating an interaction between 17beta-estradiol and Eudragit RS in the system. A variation of glass transition temperature (T(g)) of 17beta-estradiol in Eudragit RS solid dispersion was observed by MTDSC using heating program II in which the maximum temperature in the first heating run reached the 17beta-estradiol melting point. In the second heating run of heating program II, 17beta-estradiol was in an amorphous form blended with Eudragit RS. The variation in T(g) of amorphous 17beta-estradiol blended with Eudragit RS could be explained by the Kwei equation, a modified version of the Gordon-Taylor equation. The parameter estimates from the Kwei equation were consistent with an interaction between 17beta-estradiol and Eudragit RS, which was due to inter-associated hydrogen bonding as deduced from the FTIR spectra of the blends.",
author = "Chutima Wiranidchapong and Tucker, {Ian G} and Thomas Rades and Poj Kulvanich",
year = "2008",
doi = "10.1002/jps.21366",
language = "English",
volume = "97",
pages = "4879--88",
journal = "Al Azhar Journal of Pharmaceutical Sciences",
issn = "1110-1644",
number = "11",

}

RIS

TY - JOUR

T1 - Miscibility and interactions between 17beta-estradiol and Eudragit RS in solid dispersion

AU - Wiranidchapong, Chutima

AU - Tucker, Ian G

AU - Rades, Thomas

AU - Kulvanich, Poj

PY - 2008

Y1 - 2008

N2 - Miscibility of 17beta-estradiol and Eudragit RS in solid dispersions was determined by modulated temperature differential scanning calorimetry (MTDSC). A reduction of the 17beta-estradiol melting point in Eudragit RS solid dispersions was observed by MTDSC using heating program I in which the maximum temperature in the first heating run was lower than the 17beta-estradiol melting point. The melting point depression of 17beta-estradiol in solid dispersions as a function of composition could be explained by the Nishi-Wang equation indicating an interaction between 17beta-estradiol and Eudragit RS in the system. A variation of glass transition temperature (T(g)) of 17beta-estradiol in Eudragit RS solid dispersion was observed by MTDSC using heating program II in which the maximum temperature in the first heating run reached the 17beta-estradiol melting point. In the second heating run of heating program II, 17beta-estradiol was in an amorphous form blended with Eudragit RS. The variation in T(g) of amorphous 17beta-estradiol blended with Eudragit RS could be explained by the Kwei equation, a modified version of the Gordon-Taylor equation. The parameter estimates from the Kwei equation were consistent with an interaction between 17beta-estradiol and Eudragit RS, which was due to inter-associated hydrogen bonding as deduced from the FTIR spectra of the blends.

AB - Miscibility of 17beta-estradiol and Eudragit RS in solid dispersions was determined by modulated temperature differential scanning calorimetry (MTDSC). A reduction of the 17beta-estradiol melting point in Eudragit RS solid dispersions was observed by MTDSC using heating program I in which the maximum temperature in the first heating run was lower than the 17beta-estradiol melting point. The melting point depression of 17beta-estradiol in solid dispersions as a function of composition could be explained by the Nishi-Wang equation indicating an interaction between 17beta-estradiol and Eudragit RS in the system. A variation of glass transition temperature (T(g)) of 17beta-estradiol in Eudragit RS solid dispersion was observed by MTDSC using heating program II in which the maximum temperature in the first heating run reached the 17beta-estradiol melting point. In the second heating run of heating program II, 17beta-estradiol was in an amorphous form blended with Eudragit RS. The variation in T(g) of amorphous 17beta-estradiol blended with Eudragit RS could be explained by the Kwei equation, a modified version of the Gordon-Taylor equation. The parameter estimates from the Kwei equation were consistent with an interaction between 17beta-estradiol and Eudragit RS, which was due to inter-associated hydrogen bonding as deduced from the FTIR spectra of the blends.

U2 - 10.1002/jps.21366

DO - 10.1002/jps.21366

M3 - Journal article

C2 - 18351595

VL - 97

SP - 4879

EP - 4888

JO - Al Azhar Journal of Pharmaceutical Sciences

JF - Al Azhar Journal of Pharmaceutical Sciences

SN - 1110-1644

IS - 11

ER -

ID: 40353674