Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging. / Ostergaard, Jesper; Jensen, Henrik; Larsen, Susan W; Larsen, Claus; Lenke, Jim.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 100, 17.08.2014, p. 290-293.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ostergaard, J, Jensen, H, Larsen, SW, Larsen, C & Lenke, J 2014, 'Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging', Journal of Pharmaceutical and Biomedical Analysis, vol. 100, pp. 290-293. https://doi.org/10.1016/j.jpba.2014.08.014

APA

Ostergaard, J., Jensen, H., Larsen, S. W., Larsen, C., & Lenke, J. (2014). Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging. Journal of Pharmaceutical and Biomedical Analysis, 100, 290-293. https://doi.org/10.1016/j.jpba.2014.08.014

Vancouver

Ostergaard J, Jensen H, Larsen SW, Larsen C, Lenke J. Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging. Journal of Pharmaceutical and Biomedical Analysis. 2014 Aug 17;100:290-293. https://doi.org/10.1016/j.jpba.2014.08.014

Author

Ostergaard, Jesper ; Jensen, Henrik ; Larsen, Susan W ; Larsen, Claus ; Lenke, Jim. / Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging. In: Journal of Pharmaceutical and Biomedical Analysis. 2014 ; Vol. 100. pp. 290-293.

Bibtex

@article{31e106481ba14023af72adc70959c881,

title = "Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging",

abstract = "Variable dissolution from sodium salts of drugs containing a carboxylic acid group after passing the acidic environment of the stomach may affect oral bioavailability. The aim of the present proof of concept study was to investigate pH effects in relation to the dissolution of sodium naproxenate in 0.01M hydrochloric acid. For this purpose a UV/vis imaging-based approach capable of measuring microenvironmental pH in the vicinity of the solid drug compact as well as monitoring drug dissolution was developed. Using a pH indicating dye real-time spatially resolved measurement of pH was achieved. Sodium naproxenate, can significantly alter the local pH of the dissolution medium, is eventually neutralized and precipitates as the acidic species naproxen. The developed approach is considered useful for detailed studies of pH dependent dissolution phenomena in dissolution testing.",

author = "Jesper Ostergaard and Henrik Jensen and Larsen, {Susan W} and Claus Larsen and Jim Lenke",

year = "2014",

month = aug,

day = "17",

doi = "10.1016/j.jpba.2014.08.014",

language = "English",

volume = "100",

pages = "290--293",

journal = "Journal of Pharmaceutical and Biomedical Analysis",

issn = "0731-7085",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging

AU - Ostergaard, Jesper

AU - Jensen, Henrik

AU - Larsen, Susan W

AU - Larsen, Claus

AU - Lenke, Jim

PY - 2014/8/17

Y1 - 2014/8/17

N2 - Variable dissolution from sodium salts of drugs containing a carboxylic acid group after passing the acidic environment of the stomach may affect oral bioavailability. The aim of the present proof of concept study was to investigate pH effects in relation to the dissolution of sodium naproxenate in 0.01M hydrochloric acid. For this purpose a UV/vis imaging-based approach capable of measuring microenvironmental pH in the vicinity of the solid drug compact as well as monitoring drug dissolution was developed. Using a pH indicating dye real-time spatially resolved measurement of pH was achieved. Sodium naproxenate, can significantly alter the local pH of the dissolution medium, is eventually neutralized and precipitates as the acidic species naproxen. The developed approach is considered useful for detailed studies of pH dependent dissolution phenomena in dissolution testing.

AB - Variable dissolution from sodium salts of drugs containing a carboxylic acid group after passing the acidic environment of the stomach may affect oral bioavailability. The aim of the present proof of concept study was to investigate pH effects in relation to the dissolution of sodium naproxenate in 0.01M hydrochloric acid. For this purpose a UV/vis imaging-based approach capable of measuring microenvironmental pH in the vicinity of the solid drug compact as well as monitoring drug dissolution was developed. Using a pH indicating dye real-time spatially resolved measurement of pH was achieved. Sodium naproxenate, can significantly alter the local pH of the dissolution medium, is eventually neutralized and precipitates as the acidic species naproxen. The developed approach is considered useful for detailed studies of pH dependent dissolution phenomena in dissolution testing.

U2 - 10.1016/j.jpba.2014.08.014

DO - 10.1016/j.jpba.2014.08.014

M3 - Journal article

C2 - 25194341

VL - 100

SP - 290

EP - 293

JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

SN - 0731-7085

ER -

ID: 123465025

Department of Pharmacy