Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools
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Malaria causes long-term effects on markers of iron status in children : a critical assessment of existing clinical and epidemiological tools. / Castberg, Filip C; Sarbah, Edem W; Koram, Kwadwo A; Opoku, Nicholas; Ofori, Michael F; Styrishave, Bjarne; Hviid, Lars; Kurtzhals, Jørgen A L.
In: Malaria Journal, Vol. 17, No. 1, 464, 11.12.2018.Research output: Contribution to journal › Journal article › peer-review
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T1 - Malaria causes long-term effects on markers of iron status in children
T2 - a critical assessment of existing clinical and epidemiological tools
AU - Castberg, Filip C
AU - Sarbah, Edem W
AU - Koram, Kwadwo A
AU - Opoku, Nicholas
AU - Ofori, Michael F
AU - Styrishave, Bjarne
AU - Hviid, Lars
AU - Kurtzhals, Jørgen A L
N1 - Correction to: Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools (Malaria Journal, (2018), 17, 1, (464), 10.1186/s12936-018-2609-6) Filip C. Castberg, Edem W. Sarbah, Kwadwo A. Koram, Nicholas Opoku, Michael F. Ofori, Bjarne Styrishave, Lars Hviid, Jørgen A.L. Kurtzhals, 2022, vol. 21, issue 1. Malaria Journal. Correction to: Malar J (2018) 17:464 https://doi.org/10.1186/s12936-018-2609-6
PY - 2018/12/11
Y1 - 2018/12/11
N2 - BACKGROUND: Most epidemiological studies on the interplay between iron deficiency and malaria risk classify individuals as iron-deficient or iron-replete based on inflammation-dependent iron markers and adjustment for inflammation by using C-reactive protein (CRP) or α-1-acid glycoprotein (AGP). The validity of this approach and the usefulness of fibroblast growth factor 23 (FGF23) as a proposed inflammation-independent iron marker were tested.METHODS: Conventional iron markers and FGF23 were measured in children with acute falciparum malaria and after 1, 2, 4, and 6 weeks. Children, who were transfused or received iron supplementation in the follow-up period, were excluded, and iron stores were considered to be stable throughout. Ferritin levels 6 weeks after admission were used as a reference for admission iron status and compared with iron markers at different time points.RESULTS: There were long-term perturbations in iron markers during convalescence from acute malaria. None of the tested iron parameters, including FGF23, were independent of inflammation. CRP and AGP normalized faster than ferritin after malaria episodes.CONCLUSION: Malaria may bias epidemiological studies based on inflammation-dependent iron markers. Better markers of iron status during and after inflammation are needed in order to test strategies for iron supplementation in populations at risk of malaria.
AB - BACKGROUND: Most epidemiological studies on the interplay between iron deficiency and malaria risk classify individuals as iron-deficient or iron-replete based on inflammation-dependent iron markers and adjustment for inflammation by using C-reactive protein (CRP) or α-1-acid glycoprotein (AGP). The validity of this approach and the usefulness of fibroblast growth factor 23 (FGF23) as a proposed inflammation-independent iron marker were tested.METHODS: Conventional iron markers and FGF23 were measured in children with acute falciparum malaria and after 1, 2, 4, and 6 weeks. Children, who were transfused or received iron supplementation in the follow-up period, were excluded, and iron stores were considered to be stable throughout. Ferritin levels 6 weeks after admission were used as a reference for admission iron status and compared with iron markers at different time points.RESULTS: There were long-term perturbations in iron markers during convalescence from acute malaria. None of the tested iron parameters, including FGF23, were independent of inflammation. CRP and AGP normalized faster than ferritin after malaria episodes.CONCLUSION: Malaria may bias epidemiological studies based on inflammation-dependent iron markers. Better markers of iron status during and after inflammation are needed in order to test strategies for iron supplementation in populations at risk of malaria.
U2 - 10.1186/s12936-018-2609-6
DO - 10.1186/s12936-018-2609-6
M3 - Journal article
C2 - 30537973
VL - 17
JO - Malaria Journal
JF - Malaria Journal
SN - 1475-2875
IS - 1
M1 - 464
ER -
ID: 210835524