Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools

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Malaria causes long-term effects on markers of iron status in children : a critical assessment of existing clinical and epidemiological tools. / Castberg, Filip C; Sarbah, Edem W; Koram, Kwadwo A; Opoku, Nicholas; Ofori, Michael F; Styrishave, Bjarne; Hviid, Lars; Kurtzhals, Jørgen A L.

In: Malaria Journal, Vol. 17, No. 1, 464, 11.12.2018.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Castberg, FC, Sarbah, EW, Koram, KA, Opoku, N, Ofori, MF, Styrishave, B, Hviid, L & Kurtzhals, JAL 2018, 'Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools', Malaria Journal, vol. 17, no. 1, 464. https://doi.org/10.1186/s12936-018-2609-6

APA

Castberg, F. C., Sarbah, E. W., Koram, K. A., Opoku, N., Ofori, M. F., Styrishave, B., ... Kurtzhals, J. A. L. (2018). Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools. Malaria Journal, 17(1), [464]. https://doi.org/10.1186/s12936-018-2609-6

Vancouver

Castberg FC, Sarbah EW, Koram KA, Opoku N, Ofori MF, Styrishave B et al. Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools. Malaria Journal. 2018 Dec 11;17(1). 464. https://doi.org/10.1186/s12936-018-2609-6

Author

Castberg, Filip C ; Sarbah, Edem W ; Koram, Kwadwo A ; Opoku, Nicholas ; Ofori, Michael F ; Styrishave, Bjarne ; Hviid, Lars ; Kurtzhals, Jørgen A L. / Malaria causes long-term effects on markers of iron status in children : a critical assessment of existing clinical and epidemiological tools. In: Malaria Journal. 2018 ; Vol. 17, No. 1.

Bibtex

@article{2105990686cd4f3da36191709f8830d7,
title = "Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools",
abstract = "BACKGROUND: Most epidemiological studies on the interplay between iron deficiency and malaria risk classify individuals as iron-deficient or iron-replete based on inflammation-dependent iron markers and adjustment for inflammation by using C-reactive protein (CRP) or α-1-acid glycoprotein (AGP). The validity of this approach and the usefulness of fibroblast growth factor 23 (FGF23) as a proposed inflammation-independent iron marker were tested.METHODS: Conventional iron markers and FGF23 were measured in children with acute falciparum malaria and after 1, 2, 4, and 6 weeks. Children, who were transfused or received iron supplementation in the follow-up period, were excluded, and iron stores were considered to be stable throughout. Ferritin levels 6 weeks after admission were used as a reference for admission iron status and compared with iron markers at different time points.RESULTS: There were long-term perturbations in iron markers during convalescence from acute malaria. None of the tested iron parameters, including FGF23, were independent of inflammation. CRP and AGP normalized faster than ferritin after malaria episodes.CONCLUSION: Malaria may bias epidemiological studies based on inflammation-dependent iron markers. Better markers of iron status during and after inflammation are needed in order to test strategies for iron supplementation in populations at risk of malaria.",
author = "Castberg, {Filip C} and Sarbah, {Edem W} and Koram, {Kwadwo A} and Nicholas Opoku and Ofori, {Michael F} and Bjarne Styrishave and Lars Hviid and Kurtzhals, {J{\o}rgen A L}",
year = "2018",
month = "12",
day = "11",
doi = "10.1186/s12936-018-2609-6",
language = "English",
volume = "17",
journal = "Malaria Journal",
issn = "1475-2875",
publisher = "BioMed Central",
number = "1",

}

RIS

TY - JOUR

T1 - Malaria causes long-term effects on markers of iron status in children

T2 - a critical assessment of existing clinical and epidemiological tools

AU - Castberg, Filip C

AU - Sarbah, Edem W

AU - Koram, Kwadwo A

AU - Opoku, Nicholas

AU - Ofori, Michael F

AU - Styrishave, Bjarne

AU - Hviid, Lars

AU - Kurtzhals, Jørgen A L

PY - 2018/12/11

Y1 - 2018/12/11

N2 - BACKGROUND: Most epidemiological studies on the interplay between iron deficiency and malaria risk classify individuals as iron-deficient or iron-replete based on inflammation-dependent iron markers and adjustment for inflammation by using C-reactive protein (CRP) or α-1-acid glycoprotein (AGP). The validity of this approach and the usefulness of fibroblast growth factor 23 (FGF23) as a proposed inflammation-independent iron marker were tested.METHODS: Conventional iron markers and FGF23 were measured in children with acute falciparum malaria and after 1, 2, 4, and 6 weeks. Children, who were transfused or received iron supplementation in the follow-up period, were excluded, and iron stores were considered to be stable throughout. Ferritin levels 6 weeks after admission were used as a reference for admission iron status and compared with iron markers at different time points.RESULTS: There were long-term perturbations in iron markers during convalescence from acute malaria. None of the tested iron parameters, including FGF23, were independent of inflammation. CRP and AGP normalized faster than ferritin after malaria episodes.CONCLUSION: Malaria may bias epidemiological studies based on inflammation-dependent iron markers. Better markers of iron status during and after inflammation are needed in order to test strategies for iron supplementation in populations at risk of malaria.

AB - BACKGROUND: Most epidemiological studies on the interplay between iron deficiency and malaria risk classify individuals as iron-deficient or iron-replete based on inflammation-dependent iron markers and adjustment for inflammation by using C-reactive protein (CRP) or α-1-acid glycoprotein (AGP). The validity of this approach and the usefulness of fibroblast growth factor 23 (FGF23) as a proposed inflammation-independent iron marker were tested.METHODS: Conventional iron markers and FGF23 were measured in children with acute falciparum malaria and after 1, 2, 4, and 6 weeks. Children, who were transfused or received iron supplementation in the follow-up period, were excluded, and iron stores were considered to be stable throughout. Ferritin levels 6 weeks after admission were used as a reference for admission iron status and compared with iron markers at different time points.RESULTS: There were long-term perturbations in iron markers during convalescence from acute malaria. None of the tested iron parameters, including FGF23, were independent of inflammation. CRP and AGP normalized faster than ferritin after malaria episodes.CONCLUSION: Malaria may bias epidemiological studies based on inflammation-dependent iron markers. Better markers of iron status during and after inflammation are needed in order to test strategies for iron supplementation in populations at risk of malaria.

U2 - 10.1186/s12936-018-2609-6

DO - 10.1186/s12936-018-2609-6

M3 - Journal article

C2 - 30537973

VL - 17

JO - Malaria Journal

JF - Malaria Journal

SN - 1475-2875

IS - 1

M1 - 464

ER -

ID: 210835524