Low-Frequency Raman Spectroscopy as an Avenue to Determine the Transition Temperature of β- and γ-Relaxation in Pharmaceutical Glasses

Research output: Contribution to journalJournal articlepeer-review

Standard

Low-Frequency Raman Spectroscopy as an Avenue to Determine the Transition Temperature of β- and γ-Relaxation in Pharmaceutical Glasses. / Bē Rziņš, Kā Rlis; Fraser-Miller, Sara J.; Rades, Thomas; Gordon, Keith C.

In: Analytical Chemistry, Vol. 94, No. 23, 2022, p. 8241-8248.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Bē Rziņš, KR, Fraser-Miller, SJ, Rades, T & Gordon, KC 2022, 'Low-Frequency Raman Spectroscopy as an Avenue to Determine the Transition Temperature of β- and γ-Relaxation in Pharmaceutical Glasses', Analytical Chemistry, vol. 94, no. 23, pp. 8241-8248. https://doi.org/10.1021/acs.analchem.2c00371

APA

Bē Rziņš, K. R., Fraser-Miller, S. J., Rades, T., & Gordon, K. C. (2022). Low-Frequency Raman Spectroscopy as an Avenue to Determine the Transition Temperature of β- and γ-Relaxation in Pharmaceutical Glasses. Analytical Chemistry, 94(23), 8241-8248. https://doi.org/10.1021/acs.analchem.2c00371

Vancouver

Bē Rziņš KR, Fraser-Miller SJ, Rades T, Gordon KC. Low-Frequency Raman Spectroscopy as an Avenue to Determine the Transition Temperature of β- and γ-Relaxation in Pharmaceutical Glasses. Analytical Chemistry. 2022;94(23):8241-8248. https://doi.org/10.1021/acs.analchem.2c00371

Author

Bē Rziņš, Kā Rlis ; Fraser-Miller, Sara J. ; Rades, Thomas ; Gordon, Keith C. / Low-Frequency Raman Spectroscopy as an Avenue to Determine the Transition Temperature of β- and γ-Relaxation in Pharmaceutical Glasses. In: Analytical Chemistry. 2022 ; Vol. 94, No. 23. pp. 8241-8248.

Bibtex

@article{9a508dec58d146468faa38f265d5c520,
title = "Low-Frequency Raman Spectroscopy as an Avenue to Determine the Transition Temperature of β- and γ-Relaxation in Pharmaceutical Glasses",
abstract = "In an earlier investigation, low-frequency Raman (LFR) spectroscopy was shown to detect the transition temperature of the β-relaxation (Tβ) in both amorphous celecoxib and various celecoxib amorphous solid dispersions [ Bē rziņ{\v s}, K. et al. Mol. Pharmaceutics 2021, 18(10), 3882-3893 ]. In this study, we further investigated the application of this technique to determine Tβ, an important parameter for estimating crystallization potency of amorphous drugs. Alongside commercially available amorphous drugs (zafirlukast and valsartan disodium salt), differently melt-quenched samples of cimetidine were also analyzed. Overall, the variable-temperature LFR measurements allowed for an easy access to the desired information, including the even lesser transition of the tertiary relaxation motions (Tγ). Thus, the obtained results not only highlighted the sensitivity, but also the practical usefulness of this technique to elucidate (subtle) changes in molecular dynamics within amorphous pharmaceutical systems. ",
author = "{Bē Rziņ{\v s}}, {Kā Rlis} and Fraser-Miller, {Sara J.} and Thomas Rades and Gordon, {Keith C.}",
note = "Funding Information: The authors gratefully acknowledge the support from the Dodd–Walls Centre for Photonic and Quantum Technologies. ",
year = "2022",
doi = "10.1021/acs.analchem.2c00371",
language = "English",
volume = "94",
pages = "8241--8248",
journal = "Industrial And Engineering Chemistry Analytical Edition",
issn = "0003-2700",
publisher = "American Chemical Society",
number = "23",

}

RIS

TY - JOUR

T1 - Low-Frequency Raman Spectroscopy as an Avenue to Determine the Transition Temperature of β- and γ-Relaxation in Pharmaceutical Glasses

AU - Bē Rziņš, Kā Rlis

AU - Fraser-Miller, Sara J.

AU - Rades, Thomas

AU - Gordon, Keith C.

N1 - Funding Information: The authors gratefully acknowledge the support from the Dodd–Walls Centre for Photonic and Quantum Technologies.

PY - 2022

Y1 - 2022

N2 - In an earlier investigation, low-frequency Raman (LFR) spectroscopy was shown to detect the transition temperature of the β-relaxation (Tβ) in both amorphous celecoxib and various celecoxib amorphous solid dispersions [ Bē rziņš, K. et al. Mol. Pharmaceutics 2021, 18(10), 3882-3893 ]. In this study, we further investigated the application of this technique to determine Tβ, an important parameter for estimating crystallization potency of amorphous drugs. Alongside commercially available amorphous drugs (zafirlukast and valsartan disodium salt), differently melt-quenched samples of cimetidine were also analyzed. Overall, the variable-temperature LFR measurements allowed for an easy access to the desired information, including the even lesser transition of the tertiary relaxation motions (Tγ). Thus, the obtained results not only highlighted the sensitivity, but also the practical usefulness of this technique to elucidate (subtle) changes in molecular dynamics within amorphous pharmaceutical systems.

AB - In an earlier investigation, low-frequency Raman (LFR) spectroscopy was shown to detect the transition temperature of the β-relaxation (Tβ) in both amorphous celecoxib and various celecoxib amorphous solid dispersions [ Bē rziņš, K. et al. Mol. Pharmaceutics 2021, 18(10), 3882-3893 ]. In this study, we further investigated the application of this technique to determine Tβ, an important parameter for estimating crystallization potency of amorphous drugs. Alongside commercially available amorphous drugs (zafirlukast and valsartan disodium salt), differently melt-quenched samples of cimetidine were also analyzed. Overall, the variable-temperature LFR measurements allowed for an easy access to the desired information, including the even lesser transition of the tertiary relaxation motions (Tγ). Thus, the obtained results not only highlighted the sensitivity, but also the practical usefulness of this technique to elucidate (subtle) changes in molecular dynamics within amorphous pharmaceutical systems.

U2 - 10.1021/acs.analchem.2c00371

DO - 10.1021/acs.analchem.2c00371

M3 - Journal article

C2 - 35647784

AN - SCOPUS:85132048744

VL - 94

SP - 8241

EP - 8248

JO - Industrial And Engineering Chemistry Analytical Edition

JF - Industrial And Engineering Chemistry Analytical Edition

SN - 0003-2700

IS - 23

ER -

ID: 314963361