Low-Frequency Raman Spectroscopic Study on Compression-Induced Destabilization in Melt-Quenched Amorphous Celecoxib

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Low-Frequency Raman Spectroscopic Study on Compression-Induced Destabilization in Melt-Quenched Amorphous Celecoxib. / Bē Rziņš, Kā Rlis; Fraser-Miller, Sara J.; Rades, Thomas; Gordon, Keith C.

In: Molecular Pharmaceutics, Vol. 16, No. 8, 2019, p. 3678-3686.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bē Rziņš, KR, Fraser-Miller, SJ, Rades, T & Gordon, KC 2019, 'Low-Frequency Raman Spectroscopic Study on Compression-Induced Destabilization in Melt-Quenched Amorphous Celecoxib', Molecular Pharmaceutics, vol. 16, no. 8, pp. 3678-3686. https://doi.org/10.1021/acs.molpharmaceut.9b00557

APA

Bē Rziņš, K. R., Fraser-Miller, S. J., Rades, T., & Gordon, K. C. (2019). Low-Frequency Raman Spectroscopic Study on Compression-Induced Destabilization in Melt-Quenched Amorphous Celecoxib. Molecular Pharmaceutics, 16(8), 3678-3686. https://doi.org/10.1021/acs.molpharmaceut.9b00557

Vancouver

Bē Rziņš KR, Fraser-Miller SJ, Rades T, Gordon KC. Low-Frequency Raman Spectroscopic Study on Compression-Induced Destabilization in Melt-Quenched Amorphous Celecoxib. Molecular Pharmaceutics. 2019;16(8):3678-3686. https://doi.org/10.1021/acs.molpharmaceut.9b00557

Author

Bē Rziņš, Kā Rlis ; Fraser-Miller, Sara J. ; Rades, Thomas ; Gordon, Keith C. / Low-Frequency Raman Spectroscopic Study on Compression-Induced Destabilization in Melt-Quenched Amorphous Celecoxib. In: Molecular Pharmaceutics. 2019 ; Vol. 16, No. 8. pp. 3678-3686.

Bibtex

@article{39fa07cd97684e8d8589d06c0fc3a9a0,
title = "Low-Frequency Raman Spectroscopic Study on Compression-Induced Destabilization in Melt-Quenched Amorphous Celecoxib",
abstract = "A series of melt-quenched disks of amorphous celecoxib were obtained using two different cooling rates (>100 °C/min and ∼25-30 °C/min) and subjected to different compression pressures (125, 250, and 500 MPa) and dwell times (0, 30, and 60 s). The kinetics of crystallization for these differently prepared melt-quenched disks were probed using a number of methods. Low-frequency Raman spectroscopy was used to monitor isothermal crystallization kinetics, whereas dynamic differential scanning calorimetry served as a complimentary technique to identify changes in form. Although both compression parameters destabilized the amorphous celecoxib, the dwell time was found to have a more critical overall effect. Additionally, the sample history was affirmed to be a factor for limiting the magnitude of compression-induced destabilization.",
keywords = "amorphous drugs, celecoxib, compression-induced destabilization, differential scanning calorimetry, low-frequency Raman spectroscopy",
author = "{Bē Rziņ{\v s}}, {Kā Rlis} and Fraser-Miller, {Sara J.} and Thomas Rades and Gordon, {Keith C.}",
year = "2019",
doi = "10.1021/acs.molpharmaceut.9b00557",
language = "English",
volume = "16",
pages = "3678--3686",
journal = "Molecular Pharmaceutics",
issn = "1543-8384",
publisher = "American Chemical Society",
number = "8",

}

RIS

TY - JOUR

T1 - Low-Frequency Raman Spectroscopic Study on Compression-Induced Destabilization in Melt-Quenched Amorphous Celecoxib

AU - Bē Rziņš, Kā Rlis

AU - Fraser-Miller, Sara J.

AU - Rades, Thomas

AU - Gordon, Keith C.

PY - 2019

Y1 - 2019

N2 - A series of melt-quenched disks of amorphous celecoxib were obtained using two different cooling rates (>100 °C/min and ∼25-30 °C/min) and subjected to different compression pressures (125, 250, and 500 MPa) and dwell times (0, 30, and 60 s). The kinetics of crystallization for these differently prepared melt-quenched disks were probed using a number of methods. Low-frequency Raman spectroscopy was used to monitor isothermal crystallization kinetics, whereas dynamic differential scanning calorimetry served as a complimentary technique to identify changes in form. Although both compression parameters destabilized the amorphous celecoxib, the dwell time was found to have a more critical overall effect. Additionally, the sample history was affirmed to be a factor for limiting the magnitude of compression-induced destabilization.

AB - A series of melt-quenched disks of amorphous celecoxib were obtained using two different cooling rates (>100 °C/min and ∼25-30 °C/min) and subjected to different compression pressures (125, 250, and 500 MPa) and dwell times (0, 30, and 60 s). The kinetics of crystallization for these differently prepared melt-quenched disks were probed using a number of methods. Low-frequency Raman spectroscopy was used to monitor isothermal crystallization kinetics, whereas dynamic differential scanning calorimetry served as a complimentary technique to identify changes in form. Although both compression parameters destabilized the amorphous celecoxib, the dwell time was found to have a more critical overall effect. Additionally, the sample history was affirmed to be a factor for limiting the magnitude of compression-induced destabilization.

KW - amorphous drugs

KW - celecoxib

KW - compression-induced destabilization

KW - differential scanning calorimetry

KW - low-frequency Raman spectroscopy

U2 - 10.1021/acs.molpharmaceut.9b00557

DO - 10.1021/acs.molpharmaceut.9b00557

M3 - Journal article

C2 - 31246479

AN - SCOPUS:85070877326

VL - 16

SP - 3678

EP - 3686

JO - Molecular Pharmaceutics

JF - Molecular Pharmaceutics

SN - 1543-8384

IS - 8

ER -

ID: 241110495