Lipid-based formulations for oral administration of poorly water-soluble drugs

Research output: Contribution to journalJournal articlepeer-review

Standard

Lipid-based formulations for oral administration of poorly water-soluble drugs. / Mu, Huiling; Holm, René; Müllertz, Anette.

In: International Journal of Pharmaceutics, Vol. 453, No. 1, 30.08.2013, p. 215-24.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Mu, H, Holm, R & Müllertz, A 2013, 'Lipid-based formulations for oral administration of poorly water-soluble drugs', International Journal of Pharmaceutics, vol. 453, no. 1, pp. 215-24. https://doi.org/10.1016/j.ijpharm.2013.03.054

APA

Mu, H., Holm, R., & Müllertz, A. (2013). Lipid-based formulations for oral administration of poorly water-soluble drugs. International Journal of Pharmaceutics, 453(1), 215-24. https://doi.org/10.1016/j.ijpharm.2013.03.054

Vancouver

Mu H, Holm R, Müllertz A. Lipid-based formulations for oral administration of poorly water-soluble drugs. International Journal of Pharmaceutics. 2013 Aug 30;453(1):215-24. https://doi.org/10.1016/j.ijpharm.2013.03.054

Author

Mu, Huiling ; Holm, René ; Müllertz, Anette. / Lipid-based formulations for oral administration of poorly water-soluble drugs. In: International Journal of Pharmaceutics. 2013 ; Vol. 453, No. 1. pp. 215-24.

Bibtex

@article{0b28403fc1d34e3dbccdfaf7abd871c9,
title = "Lipid-based formulations for oral administration of poorly water-soluble drugs",
abstract = "Lipid-based drug delivery systems have shown great potentials in oral delivery of poorly water-soluble drugs, primarily for lipophilic drugs, with several successfully marketed products. Pre-dissolving drugs in lipids, surfactants, or mixtures of lipids and surfactants omits the dissolving/dissolution step, which is a potential rate limiting factor for oral absorption of poorly water-soluble drugs. Lipids not only vary in structures and physiochemical properties, but also in their digestibility and absorption pathway; therefore selection of lipid excipients and dosage form has a pronounced effect on the biopharmaceutical aspects of drug absorption and distribution both in vitro and in vivo. The aim of this review is to provide an overview of the different lipid-based dosage forms from a biopharmaceutical point of view and to describe effects of lipid dosage forms and lipid excipients on drug solubility, absorption and distribution.",
author = "Huiling Mu and Ren{\'e} Holm and Anette M{\"u}llertz",
note = "Copyright {\textcopyright} 2013 Elsevier B.V. All rights reserved.",
year = "2013",
month = aug,
day = "30",
doi = "10.1016/j.ijpharm.2013.03.054",
language = "English",
volume = "453",
pages = "215--24",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Lipid-based formulations for oral administration of poorly water-soluble drugs

AU - Mu, Huiling

AU - Holm, René

AU - Müllertz, Anette

N1 - Copyright © 2013 Elsevier B.V. All rights reserved.

PY - 2013/8/30

Y1 - 2013/8/30

N2 - Lipid-based drug delivery systems have shown great potentials in oral delivery of poorly water-soluble drugs, primarily for lipophilic drugs, with several successfully marketed products. Pre-dissolving drugs in lipids, surfactants, or mixtures of lipids and surfactants omits the dissolving/dissolution step, which is a potential rate limiting factor for oral absorption of poorly water-soluble drugs. Lipids not only vary in structures and physiochemical properties, but also in their digestibility and absorption pathway; therefore selection of lipid excipients and dosage form has a pronounced effect on the biopharmaceutical aspects of drug absorption and distribution both in vitro and in vivo. The aim of this review is to provide an overview of the different lipid-based dosage forms from a biopharmaceutical point of view and to describe effects of lipid dosage forms and lipid excipients on drug solubility, absorption and distribution.

AB - Lipid-based drug delivery systems have shown great potentials in oral delivery of poorly water-soluble drugs, primarily for lipophilic drugs, with several successfully marketed products. Pre-dissolving drugs in lipids, surfactants, or mixtures of lipids and surfactants omits the dissolving/dissolution step, which is a potential rate limiting factor for oral absorption of poorly water-soluble drugs. Lipids not only vary in structures and physiochemical properties, but also in their digestibility and absorption pathway; therefore selection of lipid excipients and dosage form has a pronounced effect on the biopharmaceutical aspects of drug absorption and distribution both in vitro and in vivo. The aim of this review is to provide an overview of the different lipid-based dosage forms from a biopharmaceutical point of view and to describe effects of lipid dosage forms and lipid excipients on drug solubility, absorption and distribution.

U2 - 10.1016/j.ijpharm.2013.03.054

DO - 10.1016/j.ijpharm.2013.03.054

M3 - Journal article

C2 - 23578826

VL - 453

SP - 215

EP - 224

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1

ER -

ID: 48869359