Insights into the early dissolution events of amlodipine using UV imaging and Raman spectroscopy
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Insights into the early dissolution events of amlodipine using UV imaging and Raman spectroscopy. / Boetker, Johan P; Savolainen, Marja; Koradia, Vishal; Tian, Fang; Rades, Thomas; Müllertz, Anette; Cornett, Claus; Rantanen, Jukka; Østergaard, Jesper.
In: Molecular Pharmaceutics, Vol. 8, No. 4, 2011, p. 1372-1380.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Insights into the early dissolution events of amlodipine using UV imaging and Raman spectroscopy
AU - Boetker, Johan P
AU - Savolainen, Marja
AU - Koradia, Vishal
AU - Tian, Fang
AU - Rades, Thomas
AU - Müllertz, Anette
AU - Cornett, Claus
AU - Rantanen, Jukka
AU - Østergaard, Jesper
PY - 2011
Y1 - 2011
N2 - Traditional dissolution testing determines drug release to the bulk, but does not enable an understanding of the events happening close to the surface of a solid or a tablet. UV imaging is a new imaging approach that can be used to study the dissolution behavior of chemical compounds. The UV imaging instrumentation offers recording of absorbance maps with a high spatial and temporal resolution which facilitates the abundant collection of information regarding the evolving solution concentrations. In this study, UV imaging was used to visualize the dissolution behavior of amlodipine besylate (amorphous and dihydrate forms) and amlodipine free base. The dissolution of amlodipine besylate was faster from the amorphous form than from the crystalline forms. The UV imaging investigations suggested that a solvent mediated phase transformation occurred for the amorphous amlodipine besylate and the amlodipine free base samples. Raman spectroscopy was used to confirm and probe the changes at the solid surface occurring upon contact with the dissolution media and verified the recrystallization of the amorphous form to the monohydrate. The combination of UV imaging and Raman spectroscopy is an efficient tool to obtain a deeper insight into the early events of the dissolution process.
AB - Traditional dissolution testing determines drug release to the bulk, but does not enable an understanding of the events happening close to the surface of a solid or a tablet. UV imaging is a new imaging approach that can be used to study the dissolution behavior of chemical compounds. The UV imaging instrumentation offers recording of absorbance maps with a high spatial and temporal resolution which facilitates the abundant collection of information regarding the evolving solution concentrations. In this study, UV imaging was used to visualize the dissolution behavior of amlodipine besylate (amorphous and dihydrate forms) and amlodipine free base. The dissolution of amlodipine besylate was faster from the amorphous form than from the crystalline forms. The UV imaging investigations suggested that a solvent mediated phase transformation occurred for the amorphous amlodipine besylate and the amlodipine free base samples. Raman spectroscopy was used to confirm and probe the changes at the solid surface occurring upon contact with the dissolution media and verified the recrystallization of the amorphous form to the monohydrate. The combination of UV imaging and Raman spectroscopy is an efficient tool to obtain a deeper insight into the early events of the dissolution process.
KW - Amlodipine
KW - Magnetic Resonance Spectroscopy
KW - Molecular Structure
KW - Solubility
KW - Spectrophotometry, Ultraviolet
KW - Spectrum Analysis, Raman
KW - Thermogravimetry
U2 - 10.1021/mp200205z
DO - 10.1021/mp200205z
M3 - Journal article
C2 - 21634435
VL - 8
SP - 1372
EP - 1380
JO - Molecular Pharmaceutics
JF - Molecular Pharmaceutics
SN - 1543-8384
IS - 4
ER -
ID: 33881391